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Molecular Mechanisms of Human Long-lived Plasma Cell Generation in the Bone Marrow and Spleen

Award Number: U01AI141993
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/21/2019
PERIOD OF PERFORMANCE END DATE: 12/31/2028

Group Awards By:

View Award Description

Molecular Mechanisms of Human Long-lived Plasma Cell Generation in the Bone Marrow and Spleen - Abstract: Human long-lived plasma cells (LLPCs) are responsible for the durability of life-long protection from vaccines. Our studies will address fundamental processes underlying the development, maturation and survival of human plasma cells with the final goal of determining the impact of different factors and tissue niches in the generation and durability of LLPC. We will identify if the bone marrow (BM) niche is the one and only long-lived reservoir of if the human spleen also contains niches to support LLPC. We will also unravel the complex molecular mechanisms of STAT3 and CD74 signaling in the early generation of antibody secreting cells (ASC) located in the lymph node (LN) germinal centers (GC) which are released into the blood circulation to eventually migrate to BM and possibly splenic microniches to mature into LLPC.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $699,855 )
2026	2026	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	8	1/14/2026	NON-COMPETING CONTINUATION	$699,855
														Subtotal = $699,855

Issue Date FY: 2025 ( Subtotal = $678,860 )
2025	2025	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	7	12/20/2024	NON-COMPETING CONTINUATION	$678,860
2025	2023	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	5	12/19/2024	NON-COMPETING CONTINUATION	$0
2025	2022	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	4	1/19/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $678,860

Issue Date FY: 2024 ( Subtotal = $632,408 )
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	6	12/27/2023	COMPETING CONTINUATION	$632,408
														Subtotal = $632,408

Issue Date FY: 2023 ( Subtotal = $611,606 )
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	5	12/19/2022	NON-COMPETING CONTINUATION	$611,606
2023	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	4	12/19/2022	NON-COMPETING CONTINUATION	$0
2023	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	003	4	2/27/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	3	12/19/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $611,606

Issue Date FY: 2022 ( Subtotal = $877,434 )
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	4	1/28/2022	SUPPLEMENT FOR EXPANSION	$255,683
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	4	12/8/2021	NON-COMPETING CONTINUATION	$621,751
2022	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	3	1/27/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $877,434

Issue Date FY: 2021 ( Subtotal = $885,577 )
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	3	8/25/2021	SUPPLEMENT FOR EXPANSION	$253,978
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	3	8/31/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	3	12/21/2020	NON-COMPETING CONTINUATION	$631,599
														Subtotal = $885,577

Issue Date FY: 2020 ( Subtotal = $641,161 )
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	2	8/10/2020	NON-COMPETING CONTINUATION	$0
2020	2020	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	2	1/13/2020	NON-COMPETING CONTINUATION	$641,161
														Subtotal = $641,161

Issue Date FY: 2019 ( Subtotal = $664,443 )
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	1	1/21/2019	NEW	$664,443
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	1	7/8/2019	NEW	$0
														Subtotal = $664,443

Grand Total All Awards = $5,691,344

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Molecular Mechanisms of Human Long-lived Plasma Cell Generation in the Bone Marrow and Spleen

Award Number: U01AI141993

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/21/2019

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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