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Microbial, immune, metabolic perturbations by antibiotics (MIME study)

Award Number: U01AI122285
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/13/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2023

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Microbial, immune, metabolic perturbations by antibiotics (MIME study) - Project Summary As SARS-CoV-2 is sweeping through the USA, healthcare workers (HCW) are our first line of defense. But they too are susceptible to becoming infected, resulting in physical illness, loss of productivity, and potential for disease transmission to patients. Our long-term goal is to protect HCW taking care of SARS-CoV-2-infected patients as well as their families, communities, and the general population. Our specific objective is to rapidly establish a prospective cohort to characterize the factors related to viral transmission and disease severity in a large healthcare system in both healthcare settings and workers' households. Our central hypothesis is that HCW are at higher risk of acquiring and transmitting SARS-CoV-2 and COVID-19 compared with non-healthcare workers (NCHW). We propose to address this hypothesis by recruiting and following 500 HCW and 250 age- and sex-matched NHCW within a large academic health system, Rutgers Biomedical and Health Sciences (RBHS). By intensively following participants over a six-month period and collecting serial biospecimens (nasopharyngeal swabs and blood) and questionnaire data at nine time points, we will be uniquely situated to characterize SARS- CoV-2 transmission and risk factors for COVID-19 among HCW and their families. Our specific aims are: (i), to assess the baseline prevalence of SARS-CoV-2 and COVID-19 in the study population; (ii), to characterize the natural history of SARS-CoV-2 infection in a diverse US workforce, including the incidence of asymptomatic infections and critical illness; (iii), to determine the incidence of SARS-CoV-2 and COVID-19 in healthcare workers compared with non-healthcare workers; (iv), to identify the risk factors for acquiring SARS-CoV-2 and developing COVID-19; (v), to determine the duration and extent of SARS-CoV-2 shedding; and (vi), to determine the rate and direction of transmission of SARS-CoV-2 within households. Our multidisciplinary team has the opportunity, population, resources, and motivation to immediately tackle these crucial questions and to mobilize in the early stages of this public health crisis before overwhelming infection occurs in the US. The proposed cohort study will produce immediate, actionable, and translatable knowledge about protecting the healthcare workforce. The established cohort and repository of ~15,000 biospecimens will also serve as a foundation for future mechanistic studies. The coordinated activities of our team working within a large healthcare system will advance efforts to control, treat, and prevent COVID-19, with focus on the safety of HCW and the staffing of hospitals during this continuing epidemic.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $391,307 )
2025	2025	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Allergy and Infectious Diseases Research	000	8	1/7/2025	NON-COMPETING CONTINUATION	$430,474
2025	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Allergy and Infectious Diseases Research	002	7	1/21/2025	COMPETING CONTINUATION	$1
2025	2021	RUTGERS, THE STATE UNIVERSITY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	6	1/21/2025	NON-COMPETING CONTINUATION	-$1
2025	2020	RUTGERS, THE STATE UNIVERSITY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	003	5	2/3/2025	SUPPLEMENT FOR EXPANSION	-$39,167
														Subtotal = $391,307

Issue Date FY: 2024 ( Subtotal = $458,038 )
2024	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Allergy and Infectious Diseases Research	002	7	9/12/2024	COMPETING CONTINUATION	$44,379
2024	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Allergy and Infectious Diseases Research	001	7	2/26/2024	COMPETING CONTINUATION	$413,659
2024	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	6	2/23/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $458,038

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	6	3/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	5	8/11/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $340,550 )
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	6	4/19/2021	NON-COMPETING CONTINUATION	$340,550
2021	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	5	5/3/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $340,550

Issue Date FY: 2020 ( Subtotal = $1,904,768 )
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	003	5	5/13/2020	SUPPLEMENT FOR EXPANSION	$1,558,030
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	002	5	5/5/2020	NON-COMPETING CONTINUATION	$346,738
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	004	5	6/4/2020	NON-COMPETING CONTINUATION	$0
2020	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	4	3/24/2020	EXTENSION WITH OR WITHOUT FUNDS	$258,702
2020	2018	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	3	3/24/2020	NON-COMPETING CONTINUATION	-$258,702
														Subtotal = $1,904,768

Issue Date FY: 2019 ( Subtotal = $366,946 )
2019	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	4	4/30/2019	EXTENSION WITH OR WITHOUT FUNDS	$249,738
2019	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	002	4	5/31/2019	EXTENSION WITH OR WITHOUT FUNDS	$106,645
2019	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Allergy and Infectious Diseases Research	003	4	6/13/2019	EXTENSION WITH OR WITHOUT FUNDS	$10,563
2019	2018	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	3	2/22/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $366,946

Issue Date FY: 2018 ( Subtotal = $401,969 )
2018	2018	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	3	3/19/2018	NON-COMPETING CONTINUATION	$401,969
														Subtotal = $401,969

Issue Date FY: 2017 ( Subtotal = $412,975 )
2017	2017	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	2	3/23/2017	NON-COMPETING CONTINUATION	$412,975
														Subtotal = $412,975

Issue Date FY: 2016 ( Subtotal = $423,750 )
2016	2016	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	1	3/18/2016	NEW	$423,750
														Subtotal = $423,750

Grand Total All Awards = $4,700,303

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Microbial, immune, metabolic perturbations by antibiotics (MIME study)

Award Number: U01AI122285

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/13/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2023

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