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HT-FILM-ARRAY: A SYSTEM TO ASSESS RESPIRATORY VIRUSES WITH EMPHASIS ON INFLUENZA

Award Number: U01AI074419
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2007
PERIOD OF PERFORMANCE END DATE: 07/31/2012

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HT-FILM-ARRAY: A SYSTEM TO ASSESS RESPIRATORY VIRUSES WITH EMPHASIS ON INFLUENZA - DESCRIPTION (provided by applicant): Pandemic strains of influenza have arisen in the past and will unquestionably arise in the future. Numerous respiratory viruses, including common influenza strains and pandemic strains, present with essentially identical generalized symptoms. A public health and clinical concern is distinguishing between patients infected with pandemic influenza or a common respiratory virus, to do so requires a sensitive diagnostic system. HT-FilmArray technology provides a dense format to concurrently assay for a panel of respiratory viruses including influenza but to also characterize the influenza H and N genes to differentiate strains (e.g. H5N1). HT-FilmArray employs a plastic disposable in which is performed a seamless progression of biochemical manipulations including: nucleic acid preparation, reverse transcription, PCR using a 2-stage nested multiplex process, and confirmation of product identity by high-resolution melt profiling. Nested PCR while exquisitely sensitive, has seen limited use as it is prone to amplicon contamination. HT-FilmArray contains the nested procedure such that its greatest strength (sensitivity) is realized while its greatest weakness (amplicon contamination) is eliminated. High-resolution melt profiling is used to confirm positive results. Melt profiling rapidly determines curve shape and melting temperature as a 2nd tier analysis to re-enforce positive results and to eliminate false positive results. In a pandemic scenario, communication between laboratories will enable clinicians to better diagnose patients and provide public health officials information to take steps that will contain the outbreak. Proposed is a software module allowing HT- FilmArray users, even in geographically remote locations, to communicate and share data over a secure internet connection. This data sharing module will enable privileged users to view runs in real-time from remote locations and for independent data sets to be shared and analyzed together. A data mining module will allow results to be analyzed together and provide a flexible format for data comparison. Data sharing/data mining will allow public health officials to monitor viral activity using data from multiple distantly located HT-FilmArray instruments and based upon the data make sound decisions to contain an outbreak. While this proposal is focused upon influenza, HT-FilmArray will be equally useful as a standard tool to assess patients during yearly respiratory virus epidemics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $1,206,303 )
2011	2011	BIOFIRE DIAGNOSTICS INC	149 CHESTNUT STREET	IDAHO FALLS	ID	83402	BONNEVILLE	USA	Allergy and Infectious Diseases Research	000	5	8/8/2011	NON-COMPETING CONTINUATION	$1,206,303
														Subtotal = $1,206,303

Issue Date FY: 2010 ( Subtotal = $1,749,976 )
2010	2010	IDAHO TECHNOLOGY	149 CHESTNUT STREET	IDAHO FALLS	ID	83402	BONNEVILLE	USA	Allergy and Infectious Diseases Research	000	4	7/26/2010	NON-COMPETING CONTINUATION	$1,749,976
														Subtotal = $1,749,976

Issue Date FY: 2009 ( Subtotal = $1,697,579 )
2009	2009	IDAHO TECHNOLOGY	149 CHESTNUT STREET	IDAHO FALLS	ID	83402	BONNEVILLE	USA	Allergy and Infectious Diseases Research	000	3	8/13/2009	NON-COMPETING CONTINUATION	$1,697,579
														Subtotal = $1,697,579

Issue Date FY: 2008 ( Subtotal = $1,729,147 )
2008	2008	IDAHO TECHNOLOGY	149 CHESTNUT STREET	IDAHO FALLS	ID	83402	BONNEVILLE	USA	Allergy and Infectious Diseases Research	000	2	8/1/2008	NON-COMPETING CONTINUATION	$1,729,147
														Subtotal = $1,729,147

Issue Date FY: 2007 ( Subtotal = $1,793,553 )
2007	2007	IDAHO TECHNOLOGY	149 CHESTNUT STREET	IDAHO FALLS	ID	83402	BONNEVILLE	USA	Allergy and Infectious Diseases Research	000	1	8/7/2007	NEW	$1,793,553
														Subtotal = $1,793,553

Grand Total All Awards = $8,176,558

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HT-FILM-ARRAY: A SYSTEM TO ASSESS RESPIRATORY VIRUSES WITH EMPHASIS ON INFLUENZA

Award Number: U01AI074419

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2007

PERIOD OF PERFORMANCE END DATE: 07/31/2012

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