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International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa.

Award Number: U01AI069924
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2006
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa. - Southern Africa is the epicenter of the HIV and tuberculosis (TB) epidemic, and South Africa is at the center of the COVID-19 pandemic in Africa. There is an urgent need for robust epidemiology and implementation science to address the interacting burdens of HIV, TB, and other (emerging) coinfections and non-communicable diseases (NCDs). The International epidemiology Databases to Evaluate AIDS in Southern Africa (IeDEA-SA) has defined six specific aims for the fourth funding period (IeDEA-SA IV): (1) to study outcomes along the continuum of HIV care in adults; (2) to study outcomes in pregnant women, infants, children, and adolescents; (3) to study NCDs, hepatitis B and sexually transmitted infections (STIs); (4) to study the clinical and public health epidemiology of TB; (5) to study cancer prevention, burden, and care; and (6) to study mental health and substance use disorders. Further, we defined six cross-cutting themes: (i) the impact of the COVID-19 pandemic on health services; (ii) gender equity; (iii) capacity building; (iv) digital transformation; (v) open science; and (vi) the United Nations Sustainable Development Goals, which we will develop and prioritize within each aim. Innovations include the addition of the Western Cape Provincial Health Data Centre (WC PHDC), the South African HIV Cancer Match study, the establishment of pre-Exposure prophylaxis cohorts, and the evaluation of novel technologies (for example, a point-of-care genome-sequencing device, a hand-held colposcopic device for cervical cancer screening, or tools to study the transmission of TB in the health care setting) and novel statistical and mathematical modeling approaches. Multiregional Sentinel Research Networks (NCD-Sentinel Research Network [SRN], TB-SRN, Adolescent and Young Adult Network of IeDEA) on NCDs, TB, and adolescents and youth will harmonize data collection across the six IeDEA regions in low- and middle-income countries. The Fogarty-IeDEA Mentorship Program will strengthen capacity building among early-stage investigators. IeDEA-SA now follows nearly 1.3 million people living with HIV, including 285,000 individuals from the private sector (the Aid for AIDS program AfA), and 370,000 with ART duration > ten years. IeDEA IV will add data from 600,000 HIV-negative people through AfA and information from up to 4 million HIV-negative individuals from the WC PHDC in specific analyses. Within IeDEA, the Southern African region includes by far the largest number of adults and children. The COVID-19 pandemic now highlights the importance of epidemiologic research and implementation science across the health system. IeDEA-SA is well- placed to address the specific aims and cross-cutting themes outlined in this application, through its successful track-record of collaboration between the scientific and operational leadership at the Universities of Bern and Cape Town, partnership with several African universities (including the Kwazulu-Natal Research Innovation and Sequencing Platform), United States and European universities, and with the World Health Organization and the Joint United Nations Programme on HIV/AIDS.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,279,439 )
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	006	20	9/17/2025	NON-COMPETING CONTINUATION	$1,322,206
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	010	20	9/24/2025	SUPPLEMENT FOR EXPANSION	$221,852
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	007	20	9/22/2025	SUPPLEMENT FOR EXPANSION	$367,078
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	008	20	9/24/2025	SUPPLEMENT FOR EXPANSION	$749,723
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	011	20	9/26/2025	NON-COMPETING CONTINUATION	$135,000
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	009	20	9/24/2025	SUPPLEMENT FOR EXPANSION	$682,022
2025	2024	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	005	19	11/27/2024	NON-COMPETING CONTINUATION	$0
2025	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	003	14	10/1/2024	SUPPLEMENT FOR EXPANSION	-$7,839
2025	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	000	14	10/1/2024	SUPPLEMENT FOR EXPANSION	-$25,476
2025	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	002	14	10/1/2024	SUPPLEMENT FOR EXPANSION	-$128,371
2025	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	004	14	10/1/2024	SUPPLEMENT FOR EXPANSION	-$23,434
2025	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	001	14	10/1/2024	SUPPLEMENT FOR EXPANSION	-$13,323
														Subtotal = $3,279,439

Issue Date FY: 2024 ( Subtotal = $3,119,813 )
2024	2024	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	000	19	5/1/2024	NON-COMPETING CONTINUATION	$3,060,068
2024	2024	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	002	19	7/10/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	001	19	7/3/2024	SUPPLEMENT FOR EXPANSION	$59,745
														Subtotal = $3,119,813

Issue Date FY: 2023 ( Subtotal = $3,380,907 )
2023	2023	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	005	18	6/20/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	004	18	4/27/2023	NON-COMPETING CONTINUATION	$3,179,534
2023	2023	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	006	18	7/13/2023	NON-COMPETING CONTINUATION	$201,373
2023	2021	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	001	16	11/30/2022	COMPETING CONTINUATION	-$1,564,647
2023	2021	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	003	16	12/2/2022	COMPETING CONTINUATION	$861,500
2023	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	002	15	12/2/2022	NON-COMPETING CONTINUATION	-$861,500
2023	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	000	15	11/30/2022	NON-COMPETING CONTINUATION	$1,564,647
														Subtotal = $3,380,907

Issue Date FY: 2022 ( Subtotal = $4,063,852 )
2022	2022	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE			CHE	Allergy and Infectious Diseases Research	005	17	9/13/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE			CHE	Allergy and Infectious Diseases Research	002	17	8/9/2022	NON-COMPETING CONTINUATION	$663,852
2022	2022	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE			CHE	Allergy and Infectious Diseases Research	001	17	4/29/2022	NON-COMPETING CONTINUATION	$3,400,000
2022	2021	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE			CHE	Allergy and Infectious Diseases Research	000	16	1/6/2022	COMPETING CONTINUATION	$0
2022	2021	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE			CHE	Allergy and Infectious Diseases Research	004	16	8/25/2022	COMPETING CONTINUATION	$1,564,647
2022	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE			CHE	Allergy and Infectious Diseases Research	003	15	8/25/2022	NON-COMPETING CONTINUATION	-$1,564,647
														Subtotal = $4,063,852

Issue Date FY: 2021 ( Subtotal = $3,400,000 )
2021	2021	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE			CHE	Allergy and Infectious Diseases Research	001	16	7/7/2021	COMPETING CONTINUATION	$160,719
2021	2021	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE			CHE	Allergy and Infectious Diseases Research	000	16	5/12/2021	COMPETING CONTINUATION	$3,239,281
2021	2021	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE			CHE	Allergy and Infectious Diseases Research	002	16	7/14/2021	COMPETING CONTINUATION	$0
														Subtotal = $3,400,000

Issue Date FY: 2020 ( Subtotal = $3,136,764 )
2020	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE	3012		CHE	Allergy and Infectious Diseases Research	001	14	3/3/2020	SUPPLEMENT FOR EXPANSION	$67,927
2020	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE	3012		CHE	Allergy and Infectious Diseases Research	003	15	7/8/2020	NON-COMPETING CONTINUATION	$3,068,837
2020	2019	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE	3012		CHE	Allergy and Infectious Diseases Research	002	14	3/13/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE	3012		CHE	Allergy and Infectious Diseases Research	000	14	1/30/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,136,764

Issue Date FY: 2019 ( Subtotal = $3,000,683 )
2019	2019	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE	3012		CHE	Allergy and Infectious Diseases Research	003	14	7/12/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE	3012		CHE	Allergy and Infectious Diseases Research	002	14	7/11/2019	NON-COMPETING CONTINUATION	$452,786
2019	2019	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE	3012		CHE	Allergy and Infectious Diseases Research	001	14	7/1/2019	NON-COMPETING CONTINUATION	$2,547,897
2019	2018	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE	3012		CHE	Allergy and Infectious Diseases Research	000	13	11/9/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,000,683

Issue Date FY: 2018 ( Subtotal = $2,531,588 ) (Continued on the next page)
2018	2018	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE	3012		CHE	Allergy and Infectious Diseases Research	004	13	6/15/2018	NON-COMPETING CONTINUATION	$2,531,588
2018	2017	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE	3012		CHE	Allergy and Infectious Diseases Research	003	12	5/2/2018	NON-COMPETING CONTINUATION	$0
2018	2017	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE	3012		CHE	Allergy and Infectious Diseases Research	002	12	4/18/2018	NON-COMPETING CONTINUATION	$0
Grand Total All Awards = $53,574,462

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International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa.

Award Number: U01AI069924

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2006

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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