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International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa.

Award Number: U01AI069924
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/02/2006
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa. - Modified Project Summary/Abstract IeDEA – Southern Africa is the epicenter of the HIV and tuberculosis (TB) epidemic. There is an urgent need for robust epidemiology and implementation science to address the interacting burdens of HIV, TB, and other (emerging) coinfections and non-communicable diseases (NCDs). The International epidemiology Databases to Evaluate AIDS in Southern Africa (IeDEA-SA) has defined six specific aims for the fourth funding period (IeDEA-SA IV): (1) to study outcomes along the continuum of HIV care in adults; (2) to study outcomes in pregnant women, infants, children, and adolescents; (3) to study NCDs, hepatitis B and sexually transmitted infections (STIs); (4) to study the clinical and public health epidemiology of TB; (5) to study cancer prevention, burden, and care; and (6) to study mental health and substance use disorders. Further, we defined digital transformation and open science as cross-cutting themes, which we will develop and prioritize within each aim. Innovations include the addition of the Western Cape Provincial Health Data Centre (WC PHDC), the South African HIV Cancer Match study, the establishment of pre- Exposure prophylaxis cohorts, and the evaluation of novel technologies (for example, a point-ofcare genome sequencing device, a hand-held colposcopic device for cervical cancer screening, or tools to study the transmission of TB in the health care setting) and novel statistical and mathematical modeling approaches. Multiregional Sentinel Research Networks (NCD-Sentinel Research Network [SRN], TB SRN, Adolescent and Young Adult Network of IeDEA [AYANI]) on NCDs, TB, and adolescents and youth will harmonize data collection across the six IeDEA regions in low- and middle-income countries. IeDEA-SA follows more than 1.7 million people with HIV, including 285,000 individuals from the private sector (the Aid for AIDS program AfA). IeDEA IV also added data from 600,000 HIV-negative people through AfA. Within IeDEA, the Southern African region includes by far the largest number of adults and children. IeDEA-SA is well-placed to continue to address the specific aims and cross-cutting themes outlined in this application, through its successful track-record of collaboration between the scientific and operational leadership at the Universities of Bern and Cape Town, in partnership with several U.S., African, and European universities, and with international organizations. The high burden of HIV and related comorbidities in Southern Africa, together with the large, well-established IeDEA-SA cohort infrastructure, enable efficient and adequately powered analyses of key outcomes among people with HIV that are not feasible in U.S. settings alone. Moreover, IeDEA-SA generates the greatest proportion of the data for IeDEA multiregional analyses, most of which are led by U.S. investigators and all of which include collaborators from U.S. institutions. HIV and TB remain global health threats, and reducing transmission and morbidity in high-burden regions benefits the U.S. by lowering global transmission risk, curbing drug resistance, reducing healthcare costs, and supporting economic and political stability. Additionally, investments in HIV and TB cohort research, including NCD comorbidities in these populations, drive innovation in observational epidemiology, strengthen health research, and inform interventions for other diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $3,054,653 )
2026	2026	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	020	21	8/20/2026	SUPPLEMENT FOR EXPANSION	$80,507
2026	2026	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	019	21	8/19/2026	SUPPLEMENT FOR EXPANSION	$221,852
2026	2026	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	015	21	8/6/2026	SUPPLEMENT FOR EXPANSION	$748,560
2026	2026	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	009	21	7/20/2026	EXTENSION WITH OR WITHOUT FUNDS	$1,649,716
2026	2026	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	012	21	7/31/2026	SUPPLEMENT FOR EXPANSION	$354,018
2026	2026	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	018	21	8/11/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	011	20	7/23/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	016	20	8/10/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	014	20	8/4/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	005	20	3/6/2026	NON-COMPETING CONTINUATION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	000	20	1/6/2026	NON-COMPETING CONTINUATION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	002	20	1/9/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	017	20	8/10/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	013	20	8/3/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	007	20	5/18/2026	NON-COMPETING CONTINUATION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	010	20	7/22/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	004	20	1/13/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	003	20	1/12/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	008	20	7/9/2026	NON-COMPETING CONTINUATION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	006	20	4/13/2026	NON-COMPETING CONTINUATION	$0
2026	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	001	20	1/8/2026	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $3,054,653

Issue Date FY: 2025 ( Subtotal = $2,677,925 )
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	006	20	9/17/2025	NON-COMPETING CONTINUATION	$1,322,206
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	010	20	9/24/2025	SUPPLEMENT FOR EXPANSION	$221,852
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	008	20	9/23/2025	SUPPLEMENT FOR EXPANSION	$80,508
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	007	20	9/22/2025	SUPPLEMENT FOR EXPANSION	$367,078
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	011	20	9/26/2025	NON-COMPETING CONTINUATION	$135,000
2025	2025	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	009	20	9/24/2025	SUPPLEMENT FOR EXPANSION	$749,723
2025	2024	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	005	19	11/27/2024	NON-COMPETING CONTINUATION	$0
2025	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	003	14	10/1/2024	SUPPLEMENT FOR EXPANSION	-$7,839
2025	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	000	14	10/1/2024	SUPPLEMENT FOR EXPANSION	-$25,476
2025	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	002	14	10/1/2024	SUPPLEMENT FOR EXPANSION	-$128,371
2025	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	004	14	10/1/2024	SUPPLEMENT FOR EXPANSION	-$23,434
2025	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	001	14	10/1/2024	SUPPLEMENT FOR EXPANSION	-$13,323
														Subtotal = $2,677,925

Issue Date FY: 2024 ( Subtotal = $3,119,813 )
2024	2024	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	000	19	5/1/2024	NON-COMPETING CONTINUATION	$3,060,068
2024	2024	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	002	19	7/10/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	001	19	7/3/2024	SUPPLEMENT FOR EXPANSION	$59,745
														Subtotal = $3,119,813

Issue Date FY: 2023 ( Subtotal = $3,380,907 )
2023	2023	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	004	18	4/27/2023	NON-COMPETING CONTINUATION	$3,179,534
2023	2023	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	005	18	6/20/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	006	18	7/13/2023	NON-COMPETING CONTINUATION	$201,373
2023	2021	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	001	16	11/30/2022	COMPETING CONTINUATION	-$1,564,647
2023	2021	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	003	16	12/2/2022	COMPETING CONTINUATION	$861,500
2023	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	002	15	12/2/2022	NON-COMPETING CONTINUATION	-$861,500
2023	2020	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN				CHE	Allergy and Infectious Diseases Research	000	15	11/30/2022	NON-COMPETING CONTINUATION	$1,564,647
														Subtotal = $3,380,907

Issue Date FY: 2022 ( Subtotal = $4,063,852 ) (Continued on the next page)
2022	2022	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE			CHE	Allergy and Infectious Diseases Research	005	17	9/13/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITAT BERN	HOCHSCHULSTRASSE 6	BERN	BE			CHE	Allergy and Infectious Diseases Research	002	17	8/9/2022	NON-COMPETING CONTINUATION	$663,852
Grand Total All Awards = $56,027,601

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International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa.

Award Number: U01AI069924

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/02/2006

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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