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DURBAN INTERNATIONAL CLINICAL TRIALS UNIT

Award Number: U01AI069426
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2007
PERIOD OF PERFORMANCE END DATE: 01/31/2014

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DURBAN INTERNATIONAL CLINICAL TRIALS UNIT - DESCRIPTION (provided by applicant): This Durban CTU application is underpinned by a central administrative hub that serves the 3 HIV Clinical Research Sites included in this application. They bring together 3 major disciplines, most affected by the rising morbidity and mortality from HIV/AIDS viz. adult medicine, pediatrics, and obstetrics and gynecology from the University of KwaZulu-Natal, to develop and promote research into Translational Drug Research, Optimization of Clinical Management and Co-morbidities and to complement prevention and vaccine research programs in the region. The Principal Investigator, Prof. Umesh Lalloo, (also Site Leader for the Adult HIV Research Clinic) is supported by site experienced Site Leaders for the other research clinics proposed. Administration, Pharmacy, Lab Services and Data Management are the shared resources for all three sites. The long-term objectives are to: 1. Promote development of new strategies (drugs, immunomodulation, and regimens) to simplify the complex treatment of HIV/AIDS, given the immense impact of the epidemic in resource limited settings. This will ensure optimal treatment options in a Clade C HIV epidemic and where the threat of ARV drug resistance is serious and drug interactions are important, given the multiple co-morbidities 2. Promote the development of optimal strategies to treatment the complications of HIV, which contributes to the rising morbidity and mortality 3. Promote the development of scientific and clinical research expertise in resource limited settings in individuals from previously disadvantaged groups.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $2,429,118 )
2011	2011	UKZN INNOVATION (PTY) LTD	69 FRANCOIS ROAD ROOM 054	DURBAN				ZAF	Allergy and Infectious Diseases Research	004	5	6/7/2011	NON-COMPETING CONTINUATION	$162,227
2011	2011	UKZN INNOVATION (PTY) LTD	20 KINGS MEAD BOULEVARD	DURBAN		4013		ZAF	Allergy and Infectious Diseases Research	003	5	3/17/2011	NON-COMPETING CONTINUATION	$0
2011	2011	UKZN INNOVATION (PTY) LTD	69 FRANCOIS ROAD ROOM 054	DURBAN				ZAF	Allergy and Infectious Diseases Research	002	5	2/10/2011	NON-COMPETING CONTINUATION	-$179,619
2011	2011	UKZN INNOVATION (PTY) LTD	69 FRANCOIS ROAD ROOM 054	DURBAN				ZAF	Allergy and Infectious Diseases Research	001	5	1/28/2011	NON-COMPETING CONTINUATION	$1,542,556
2011	2011	UKZN INNOVATION (PTY) LTD	69 FRANCOIS ROAD ROOM 054	DURBAN				ZAF	Allergy and Infectious Diseases Research	006	5	8/30/2011	NON-COMPETING CONTINUATION	$903,954
2011	2011	UKZN INNOVATION (PTY) LTD	20 KINGS MEAD BOULEVARD	DURBAN		4013		ZAF	Allergy and Infectious Diseases Research	005	5	7/12/2011	NON-COMPETING CONTINUATION	$0
2011	2010	UKZN INNOVATION (PTY) LTD	20 KINGS MEAD BOULEVARD	DURBAN		4013		ZAF	Allergy and Infectious Diseases Research	000	4	11/8/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,429,118

Issue Date FY: 2010 ( Subtotal = $2,651,567 )
2010	2010	KWAZULU-NATAL UNIVESITY HEALTH PTY LTD	69 FRANCOIS ROAD ROOM 054	DURBAN				ZAF	Allergy and Infectious Diseases Research	000	4	2/23/2010	NON-COMPETING CONTINUATION	$1,651,567
2010	2010	UKZN INNOVATION (PTY) LTD	20 KINGS MEAD BOULEVARD	DURBAN		4013		ZAF	Allergy and Infectious Diseases Research	001	4	5/14/2010	NON-COMPETING CONTINUATION	$0
2010	2010	KWAZULU-NATAL UNIVESITY HEALTH PTY LTD	69 FRANCOIS ROAD ROOM 054	DURBAN				ZAF	Allergy and Infectious Diseases Research	002	4	9/16/2010	NON-COMPETING CONTINUATION	$1,000,000
														Subtotal = $2,651,567

Issue Date FY: 2009 ( Subtotal = $2,855,468 )
2009	2009	KWAZULU-NATAL UNIVESITY HEALTH PTY LTD	69 FRANCOIS ROAD ROOM 054	DURBAN				ZAF	Allergy and Infectious Diseases Research	000	3	3/2/2009	NON-COMPETING CONTINUATION	$1,642,478
2009	2009	KWAZULU-NATAL UNIVESITY HEALTH PTY LTD	69 FRANCOIS ROAD ROOM 054	DURBAN				ZAF	Allergy and Infectious Diseases Research	002	3	9/23/2009	NON-COMPETING CONTINUATION	$1,030,494
2009	2009	KWAZULU-NATAL UNIVESITY HEALTH PTY LTD	69 FRANCOIS ROAD ROOM 054	DURBAN				ZAF	Allergy and Infectious Diseases Research	001	3	4/7/2009	NON-COMPETING CONTINUATION	$182,496
														Subtotal = $2,855,468

Issue Date FY: 2008 ( Subtotal = $1,729,976 )
2008	2008	KWAZULU-NATAL UNIVESITY HEALTH PTY LTD	69 FRANCOIS ROAD ROOM 054	DURBAN					Allergy and Infectious Diseases Research	000	2	2/14/2008	NON-COMPETING CONTINUATION	$1,729,976
														Subtotal = $1,729,976

Issue Date FY: 2007 ( Subtotal = $1,520,647 )
2007	2007	UNIVERSITY OF PRETORIA	CLINICAL BUILDING BAG X169	PRETORIA		00000		ZAF	Allergy and Infectious Diseases Research	000	1	2/23/2007	NEW	$1,520,647
														Subtotal = $1,520,647

Grand Total All Awards = $11,186,776

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DURBAN INTERNATIONAL CLINICAL TRIALS UNIT

Award Number: U01AI069426

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2007

PERIOD OF PERFORMANCE END DATE: 01/31/2014

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