Wednesday, December 4, 2024 12/4/2024

Hematopoietic Stem Cell And Cord Blood Transplantation

Award Number: U01AI069197
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT Hematopoietic cell transplantation from unrelated donors, haploidentical related donors and cord blood units can cure life-threatening blood disorders; however, graft-versus-host disease (GVHD), relapse and survivorship disparities across different ancestries remain the major obstacles. When matched donors are not available, the properties of HLA mismatches that govern (non)-permissivity are not well-defined. Furthermore, the role of KIR/HLA interactions in modulating relapse remain to be clarified. These deficiencies have important implications for a large fraction of patients who lack HLA-matched donors, and for all patients at risk for disease relapse. We have demonstrated that HLA class I leader peptides, HLA-DP expression, and HLA/KIR interactions each contribute to GVHD, relapse and mortality. The unmet needs are to understand the mechanisms through which HLA and KIR genes modulate transplant risks, and a means to apply the research findings to clinical care. We propose to define the underlying mechanisms through which HLA and KIR genes and proteins function in transplantation, and develop tools for using HLA and KIR in the selection of the optimal transplant donor and cord blood unit. The specific aims are to: define the role of HLA-DP expression and peptide-binding groove pocket in GVHD; define NKG2/HLA-E interactions and HLA-G in GVHD and relapse; define the role for KIR and HLA interaction in relapse after HCT for acute leukemia, and design tools to evaluate gene features in clinical practice. The goals will be achieved through systemic analysis of individual gene variation, haplotypes of genes, and receptor/ligand recognition in large ethnically diverse transplant populations with complete clinical data. This proposal will fill the knowledge gap in the immunobiological basis of GVHD, relapse and survivorship disparities in transplantation. The information will increase the safety, efficacy and availability of transplantation for all patients in need of this life-saving therapy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $851,183 )
2024	2024	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	21	4/17/2024	NON-COMPETING CONTINUATION	$851,183
														Subtotal = $851,183

Issue Date FY: 2023 ( Subtotal = $820,502 )
2023	2023	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	20	4/5/2023	NON-COMPETING CONTINUATION	$820,502
														Subtotal = $820,502

Issue Date FY: 2022 ( Subtotal = $729,767 )
2022	2022	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	19	6/9/2022	NON-COMPETING CONTINUATION	$729,767
2022	2021	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	002	17	6/15/2022	NON-COMPETING CONTINUATION	$0
2022	2021	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	007	18	9/28/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$112,029
2022	2021	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	003	17	8/2/2022	NON-COMPETING CONTINUATION	-$42,304
2022	2021	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	005	17	9/27/2022	NON-COMPETING CONTINUATION	-$112,029
2022	2021	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	18	5/27/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$42,304
2022	2009	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Trans-NIH Recovery Act Research Support	006	5	9/28/2022	SUPPLEMENT FOR EXPANSION	-$112,029
2022	2009	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Trans-NIH Recovery Act Research Support	004	5	9/27/2022	SUPPLEMENT FOR EXPANSION	$112,029
														Subtotal = $729,767

Issue Date FY: 2021 ( Subtotal = $785,828 )
2021	2021	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	003	17	4/27/2021	NON-COMPETING CONTINUATION	$785,828
2021	2020	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	002	16	2/10/2021	COMPETING CONTINUATION	$0
2021	2020	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	16	2/8/2021	COMPETING CONTINUATION	$78,251
2021	2019	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	15	2/8/2021	NON-COMPETING CONTINUATION	-$78,251
														Subtotal = $785,828

Issue Date FY: 2020 ( Subtotal = $808,331 )
2020	2020	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	002	16	8/20/2020	COMPETING CONTINUATION	$0
2020	2020	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	16	7/10/2020	COMPETING CONTINUATION	$808,331
2020	2019	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	15	11/29/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $808,331

Issue Date FY: 2019 ( Subtotal = $752,565 )
2019	2019	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	15	7/1/2019	NON-COMPETING CONTINUATION	$752,565
2019	2018	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	14	3/29/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $752,565

Issue Date FY: 2018 ( Subtotal = $717,187 )
2018	2018	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	14	6/29/2018	NON-COMPETING CONTINUATION	$717,187
														Subtotal = $717,187

Issue Date FY: 2017 ( Subtotal = $755,861 )
2017	2017	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	13	6/30/2017	NON-COMPETING CONTINUATION	$755,861
														Subtotal = $755,861

Issue Date FY: 2016 ( Subtotal = $822,437 )
2016	2016	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	12	6/28/2016	NON-COMPETING CONTINUATION	$822,437
														Subtotal = $822,437

Issue Date FY: 2015 ( Subtotal = $952,157 )
2015	2015	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	11	7/1/2015	COMPETING CONTINUATION	$952,157
														Subtotal = $952,157

Issue Date FY: 2014 ( Subtotal = $936,216 )
2014	2014	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	10	7/8/2014	NON-COMPETING CONTINUATION	$936,216
														Subtotal = $936,216

Issue Date FY: 2013 ( Subtotal = $873,791 )
2013	2013	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	9	7/24/2013	NON-COMPETING CONTINUATION	$873,791
														Subtotal = $873,791

Issue Date FY: 2012 ( Subtotal = $1,182,826 )
2012	2012	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	8	6/22/2012	NON-COMPETING CONTINUATION	$884,990
2012	2012	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	8	7/30/2012	NON-COMPETING CONTINUATION	$297,836
														Subtotal = $1,182,826

Issue Date FY: 2011 ( Subtotal = $1,130,940 )
2011	2011	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	7	9/6/2011	NON-COMPETING CONTINUATION	$185,525
2011	2011	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	7	7/14/2011	NON-COMPETING CONTINUATION	$945,415
														Subtotal = $1,130,940

Issue Date FY: 2010 ( Subtotal = $1,058,211 )
2010	2010	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	6	6/29/2010	COMPETING CONTINUATION	$1,058,211
														Subtotal = $1,058,211

Issue Date FY: 2009 ( Subtotal = $1,308,574 ) (Continued on the next page)
2009	2009	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Trans-NIH Recovery Act Research Support	003	5	9/30/2009	SUPPLEMENT FOR EXPANSION	$0
2009	2009	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	5	7/20/2009	NON-COMPETING CONTINUATION	$67,138
2009	2009	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	5	2/24/2009	NON-COMPETING CONTINUATION	$604,251
2009	2009	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	002	5	9/29/2009	NON-COMPETING CONTINUATION	$0
Grand Total All Awards = $17,127,805

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Hematopoietic Stem Cell And Cord Blood Transplantation

Award Number: U01AI069197

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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