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Characterizing the Genetic Risk for Alzheimer Disease in African and Admixed African-American Ancestries

Award Number: U01AG084545
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Characterizing the Genetic Risk for Alzheimer Disease in African and Admixed African-American Ancestries - ABSTRACT AD is the leading cause of dementia in the elderly in all ethnic and racial groups, but most genetic studies for AD are in non-Hispanic Whites (NHW) of European ancestry, resulting in a lack of generalizability of findings across more diverse ancestries. This is problematic, as initial studies in African Americans (AA), who have a higher prevalence of AD compared to NHW, have already revealed differences in risk effect sizes in known loci (e.g., APOE; ABCA7), indicating multiple unique patterns of risk. Therefore, the Alzheimer's Disease Sequencing Project (ADSP) aims to encompass the richest possible global ancestries and currently includes over 55,000 funded samples for whole genome sequencing (> 19,000 NHW, >14,000 HL ancestry, and > 8,000 African Ancestry cases and controls). Thus, in this ADSP-FUS 2.0 application, which focuses on the PAR-21-212 goal to increase diversity cohorts in the ADSP, we are proposing generating whole genome sequencing, AD plasma biomarkers and cardiovascular disease biomarkers in an additional ~9,000 individuals of African ancestry (~5,000 African, ~4,000 African American) ascertained as part of the ongoing “Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP” (READD-ADSP U19 AG074865). Further, we will acquire MRI data from 200 Nigerian participants. We will perform longitudinal follow-up visits on mild cognitively impaired and cognitively unimpaired individuals after ~4 years to further evaluate clinical and biomarker level changes longitudinally associated with status conversion. This increase in sample size enhances our ability in this proposal to detect and analyze rare genetic variants contributing to the risk and protection of AD in individuals of African ancestry and understand underlying risk correlated with cardiovascular disease risk and AD plasma biomarkers. Taken together, this project will leverage the resources collected under the READD-ADSP to begin to unravel the AD risk for individuals of African ancestry while providing an invaluable resource for the AD research community at-large.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $6,541,503 )
2026	2026	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	006	3	8/23/2026	SUPPLEMENT FOR EXPANSION	$47,231
2026	2026	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	003	3	8/12/2026	NON-COMPETING CONTINUATION	$6,068,489
2026	2026	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	005	3	8/22/2026	SUPPLEMENT FOR EXPANSION	$46,335
2026	2026	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	004	3	8/21/2026	SUPPLEMENT FOR EXPANSION	$379,448
2026	2025	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	002	2	3/17/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2025	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	001	2	3/17/2026	NON-COMPETING CONTINUATION	$0
2026	2025	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	000	2	3/3/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,541,503

Issue Date FY: 2025 ( Subtotal = $3,981,728 )
2025	2025	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	002	2	8/26/2025	SUPPLEMENT FOR EXPANSION	$86,462
2025	2025	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	001	2	8/19/2025	NON-COMPETING CONTINUATION	$3,895,266
2025	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	000	1	11/13/2024	NEW	$0
														Subtotal = $3,981,728

Issue Date FY: 2024 ( Subtotal = $4,050,927 )
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	000	1	9/26/2024	NEW	$4,050,927
														Subtotal = $4,050,927

Grand Total All Awards = $14,574,158

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Characterizing the Genetic Risk for Alzheimer Disease in African and Admixed African-American Ancestries

Award Number: U01AG084545

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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