Sunday, July 6, 2025 7/6/2025

UF PASS Administrative Supplement: Regulation of exercise transducers

Award Number: U01AG055137
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2016
PERIOD OF PERFORMANCE END DATE: 11/30/2023

Group Awards By:

View Award Description

UF PASS Administrative Supplement: Regulation of exercise transducers - Summary Given the importance of physical activity in healthy living and prevention and treatment of many diseases, it is not surprising that determining the molecular mechanisms or “map” of the exercise response has become an important focus of biomedical research. The Molecular Transducers of Physical Activity in Humans Consortium (MoTrPAC) is a multicenter consortium that is currently being designed to achieve this important goal. The UF PASS Phase 2 experiments have been focused on two goals. The first has been to develop the use of a new method to support the discovery of factors released from muscle during exercise. The tool is the TurboID enzyme that can label proteins in close proximity with a biotin moiety. With this labeling we can selectively extract proteins derived from skeletal muscle with streptavidin beads from other peripheral tissues and blood. The second goal of our Phase 2 experiments is focused on direct determination of transcription factors within the nucleus following acute exercise to support the known changes in gene expression. To approach this challenge, we have optimized isolation of nuclei from tissue, starting with muscle tissue. We have identified enriched clusters of proteins that are associated with transcription, RNA processing and chromatin remodeling that provide insight in the muscle changes. For this supplement, we would like to take these studies to publication with inclusion of additional tissues such as liver, kidney and colon. We have proposed the following three specific aims with associated manuscripts: Specific Aim 1. To develop the TurboID methodology for discover of proteins released from muscle at 4 and 24hrs following an acute bout of exercise. Manuscript 1 Specific Aim 2. To define the nuclear proteome changes with acute exercise in liver, lung and muscle at immediate post exercise and 1hr post exercise. Identify novel pathways discovered with this approach, map targeted transcription factor changes coupled with gene expression with deep RNA sequencing. Manuscript 2 Specific Aim 3. To write, at least one other manuscript using MoTrPAC PASS data already available. One plan is to focus on the acute transcriptional response to exercise data in muscle, and other tissues to define common and unique genomic and transcriptomic responses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$41,848 )
2025	2023	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	6	4/7/2025	SUPPLEMENT FOR EXPANSION	-$41,848
														Subtotal = -$41,848

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	6	3/14/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $349,097 )
2023	2023	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	6	6/9/2023	SUPPLEMENT FOR EXPANSION	$349,097
														Subtotal = $349,097

Issue Date FY: 2022 ( Subtotal = $500,889 )
2022	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	002	6	5/5/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	001	6	1/14/2022	SUPPLEMENT FOR EXPANSION	$66,135
2022	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	6	12/23/2021	NON-COMPETING CONTINUATION	$434,754
														Subtotal = $500,889

Issue Date FY: 2021 ( Subtotal = $843,689 )
2021	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	001	5	4/5/2021	SUPPLEMENT FOR EXPANSION	$374,250
2021	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	5	2/4/2021	NON-COMPETING CONTINUATION	$434,848
2021	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	002	5	5/25/2021	SUPPLEMENT FOR EXPANSION	$34,591
														Subtotal = $843,689

Issue Date FY: 2020 ( Subtotal = $435,045 )
2020	2020	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	002	4	6/30/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	001	4	1/30/2020	NON-COMPETING CONTINUATION	$43,504
2020	2020	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	4	12/26/2019	NON-COMPETING CONTINUATION	$391,541
														Subtotal = $435,045

Issue Date FY: 2019 ( Subtotal = $429,863 )
2019	2019	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	001	3	6/28/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	3	11/9/2018	NON-COMPETING CONTINUATION	$429,863
														Subtotal = $429,863

Issue Date FY: 2018 ( Subtotal = $440,669 )
2018	2018	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	2	12/4/2017	NON-COMPETING CONTINUATION	$440,669
														Subtotal = $440,669

Issue Date FY: 2017 ( Subtotal = $164,512 )
2017	2017	UNIVERSITY OF FLORIDA	207 GRINTER HALL	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	1	12/9/2016	NEW	$22,499
2017	2017	UNIVERSITY OF FLORIDA	207 GRINTER HALL	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	001	1	9/21/2017	SUPPLEMENT FOR EXPANSION	$142,013
														Subtotal = $164,512

Grand Total All Awards = $3,121,916

Top

All Categories

About

Search

Reports

Data Submission

Award Information

UF PASS Administrative Supplement: Regulation of exercise transducers

Award Number: U01AG055137

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2016

PERIOD OF PERFORMANCE END DATE: 11/30/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer