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Caenorhabditis Intervention Testing Program: Interventions That Modulate Health, Longevity and Aging Hallmarks

Award Number: U01AG045864
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Caenorhabditis Intervention Testing Program: Interventions That Modulate Health, Longevity and Aging Hallmarks - Caenorhabditis Intervention Testing Program Renewal--Project Summary Health challenges linked to human aging take a tremendous toll on society. Physical and cognitive decline limit the quality of life for the elderly and their caregivers. Aging is the major risk factor for, and possible cause of, cancer, diabetes, and neurodegenerative disease. Without question, the promotion of healthy aging with extended resistance to decline and disease should be a major objective of current medical research. Fortunately, tremendous progress has been made in the biology of aging field and the science is poised to be translated into preclinical and clinical science. Simple animals models such as the nematode Caenorhabditis elegans have been at the heart of this success. Many genes and chemical compound interventions that modulate aging processes are likely to act similarly in humans. The goal of the proposed work is to continue, and expand, efforts of a co-operative scientific group involving three closely interacting laboratories who coordinately test pharmacological interventions for their ability to extend healthy aging and promote longevity in nematodes. A specific emphasis of this integrated super-group is to test promising compound on a collection of natural variants of the Caenorhabditis genus, which together represent the extensive genetic heterogeneity in the human population. The idea is that treatments that confer positive outcomes across a diverse population will have an increased chance of being effective in humans. The emphasis of this specific proposal is the screening of test compounds for the capacity to promote longevity and health across a genetically diverse test set. We will consider compounds via a public access portal, from leads in the literature, and from high throughput chemical screens for longevity. Our labs will also develop and test utility of engineered deletions of genes encoding fundamental executors of proteostasis, metabolism, intercellular signaling and mitochondrial maintenance in diverse genetic backgrounds for compound evaluation. By creating “at risk’ strains impaired in conserved hallmarks of aging, we might increase the dynamic range for identifying anti-aging therapies. We will expand understanding of mechanisms for the most effective compounds, aiding their translation. Overall, we will participate in a unique team project that has the power to define pharmacological interventions that robustly promote strong healthspan across a varied population, with implications for development of therapies that promote healthy human aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	11	3/6/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $596,187 )
2024	2024	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	001	11	7/11/2024	NON-COMPETING CONTINUATION	$596,187
2024	2023	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	10	4/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $596,187

Issue Date FY: 2023 ( Subtotal = $613,124 )
2023	2023	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	004	10	8/16/2023	NON-COMPETING CONTINUATION	$613,124
2023	2022	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	9	7/20/2023	COMPETING CONTINUATION	-$629,570
2023	2022	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	002	9	8/9/2023	COMPETING CONTINUATION	$35,445
2023	2022	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	001	9	7/24/2023	COMPETING CONTINUATION	$629,570
2023	2022	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	003	8	8/9/2023	SUPPLEMENT FOR EXPANSION	-$35,445
														Subtotal = $613,124

Issue Date FY: 2022 ( Subtotal = $1,020,500 )
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	8	6/8/2022	SUPPLEMENT FOR EXPANSION	$390,930
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	003	9	8/4/2022	COMPETING CONTINUATION	$629,570
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	002	8	8/3/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	001	8	8/3/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,020,500

Issue Date FY: 2021 ( Subtotal = $518,661 )
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	001	8	4/29/2021	NON-COMPETING CONTINUATION	$518,661
2021	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	7	12/2/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $518,661

Issue Date FY: 2020 ( Subtotal = $533,459 )
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	7	5/22/2020	NON-COMPETING CONTINUATION	$533,459
														Subtotal = $533,459

Issue Date FY: 2019 ( Subtotal = $871,318 )
2019	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	001	6	6/18/2019	SUPPLEMENT FOR EXPANSION	$323,494
2019	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	6	6/12/2019	NON-COMPETING CONTINUATION	$547,824
														Subtotal = $871,318

Issue Date FY: 2018 ( Subtotal = $561,009 )
2018	2018	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	004	5	5/4/2018	NON-COMPETING CONTINUATION	$561,009
2018	2017	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	001	4	2/15/2018	COMPETING CONTINUATION	$575,315
2018	2017	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	4	2/13/2018	COMPETING CONTINUATION	-$575,315
2018	2016	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	003	3	4/9/2018	SUPPLEMENT FOR EXPANSION	$0
2018	2015	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	002	3	4/9/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $561,009

Issue Date FY: 2017 ( Subtotal = $575,315 )
2017	2017	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	001	4	4/26/2017	COMPETING CONTINUATION	$575,315
2017	2015	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	3	4/21/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $575,315

Issue Date FY: 2016 ( Subtotal = $302,251 )
2016	2016	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLAZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	3	6/7/2016	SUPPLEMENT FOR EXPANSION	$302,251
														Subtotal = $302,251

Issue Date FY: 2015 ( Subtotal = $406,662 )
2015	2015	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLAZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	3	7/6/2015	NON-COMPETING CONTINUATION	$406,662
														Subtotal = $406,662

Issue Date FY: 2014 ( Subtotal = $419,239 )
2014	2014	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLAZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	2	6/3/2014	NON-COMPETING CONTINUATION	$419,239
														Subtotal = $419,239

Issue Date FY: 2013 ( Subtotal = $456,985 )
2013	2013	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLAZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Aging Research	000	1	8/7/2013	NEW	$456,985
														Subtotal = $456,985

Grand Total All Awards = $6,874,710

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Caenorhabditis Intervention Testing Program: Interventions That Modulate Health, Longevity and Aging Hallmarks

Award Number: U01AG045864

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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