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Interventions That Retard Mammalian Aging

Award Number: U01AG022308
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2003
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Interventions That Retard Mammalian Aging - PROJECT SUMMARY Identification of interventions that extend mouse lifespan provides new insights into mechanisms of longevity determination in mammals and may lay the groundwork for eventual anti-aging therapies in humans. The NIA Interventions Testing Program (ITP) evaluates drugs proposed to extend mouse lifespan by retardation of aging or postponement of late life diseases. Interventions proposed by multiple collaborating scientists from the research community are tested, in parallel, at three sites (The Jackson Laboratory, University of Michigan and University of Texas), using very similar, standardized protocols, and using enough genetically heterogeneous mice to provide 80% power for detecting changes in lifespan of 10%, for either sex, after pooling data from any two of the test sites. One hundred and two such lifespan experiments, involving various doses of 66 distinct agents, have been initiated in the first twenty years of the ITP. Thirty-six experiments have involved comparative tests of multiple doses of effective agents, variable starting ages, or alternative dosing schedules. Statistically significant effects on longevity, in one or both sexes, have been documented and then confirmed for NDGA, rapamycin, acarbose, 17-α-estradiol (17aE2), and canagliflozin. Significant effects were also noted for Protandim, glycine, meclizine, captopril, and astaxanthin. Lifespan trials are now underway for 25 new agents. ITP survival results have also documented longevity benefits from four agents started in middle-age: rapamycin, acarbose, 17aE2, and canagliflozin. A Collaborative Interactions Program (CIP) has provided tissues from ITP drug-treated mice to an open, growing, international network of scientific collaborators, meeting 26 requests from 17 distinct laboratories in the previous five-year period. Plans for the next five-year period include additional lifespan ( Stage 1 ) studies, detailed studies ( Stage 2 ) of drugs found to increase lifespan, transition from the CIP to an Interventions Biospecimens Repository, additional diagnostic specificity in pathological assessments, inclusion of RNA-Seq data in all Stage 2 studies, and comprehensive pharmacokinetic assessments of drugs found to increase lifespan, as well as continued collaborative work with a network of scientists to study drug effects on postulated aging mechanisms and links to disease. Site-specific studies at The Jackson Laboratory will add a tests for heart, kidney, and bladder function in Stage 2 studies, and image analysis of tissues using machine learning. The work proposed should allow the ITP to continue to make major contributions to mammalian aging biology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	21	5/2/2025	COMPETING CONTINUATION	$4
2025	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	20	5/2/2025	NON-COMPETING CONTINUATION	-$4
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,770,002 )
2024	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	21	6/3/2024	COMPETING CONTINUATION	$1,770,002
2024	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	20	2/7/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,770,002

Issue Date FY: 2023 ( Subtotal = $1,750,000 )
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	20	3/22/2023	NON-COMPETING CONTINUATION	$1,750,000
														Subtotal = $1,750,000

Issue Date FY: 2022 ( Subtotal = $1,750,000 )
2022	2022	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	19	5/11/2022	NON-COMPETING CONTINUATION	$1,750,000
2022	2019	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	15	9/26/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,750,000

Issue Date FY: 2021 ( Subtotal = $1,871,763 )
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	18	3/31/2021	NON-COMPETING CONTINUATION	$1,750,000
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	18	9/9/2021	SUPPLEMENT FOR EXPANSION	$121,763
														Subtotal = $1,871,763

Issue Date FY: 2020 ( Subtotal = $1,750,000 )
2020	2020	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	17	5/15/2020	NON-COMPETING CONTINUATION	$1,750,000
2020	2019	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	002	16	5/18/2020	COMPETING CONTINUATION	$54,257
2020	2019	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	15	5/18/2020	SUPPLEMENT FOR EXPANSION	-$54,257
														Subtotal = $1,750,000

Issue Date FY: 2019 ( Subtotal = $1,750,000 )
2019	2019	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	15	4/10/2019	SUPPLEMENT FOR EXPANSION	$850,000
2019	2019	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	004	16	9/17/2019	COMPETING CONTINUATION	$900,000
2019	2019	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	006	15	9/18/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	003	15	9/17/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	15	3/11/2019	NON-COMPETING CONTINUATION	$0
2019	2018	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	002	15	9/17/2019	NON-COMPETING CONTINUATION	$0
2019	2018	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	005	15	9/18/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,750,000

Issue Date FY: 2018 ( Subtotal = $1,749,997 )
2018	2018	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	15	5/8/2018	NON-COMPETING CONTINUATION	$1,749,997
														Subtotal = $1,749,997

Issue Date FY: 2017 ( Subtotal = $1,749,997 )
2017	2017	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	14	3/30/2017	NON-COMPETING CONTINUATION	$1,574,996
2017	2017	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	002	14	6/23/2017	NON-COMPETING CONTINUATION	$175,001
2017	2013	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	10	5/8/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,749,997

Issue Date FY: 2016 ( Subtotal = $1,749,997 )
2016	2016	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	13	3/31/2016	NON-COMPETING CONTINUATION	$1,749,997
														Subtotal = $1,749,997

Issue Date FY: 2015 ( Subtotal = $1,697,497 )
2015	2015	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	12	4/3/2015	NON-COMPETING CONTINUATION	$1,697,497
														Subtotal = $1,697,497

Issue Date FY: 2014 ( Subtotal = $1,739,497 )
2014	2014	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	11	8/13/2014	COMPETING CONTINUATION	$1,739,497
2014	2013	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	10	8/8/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,739,497

Issue Date FY: 2013 ( Subtotal = $756,922 )
2013	2013	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	10	7/5/2013	NON-COMPETING CONTINUATION	$756,922
														Subtotal = $756,922

Issue Date FY: 2012 ( Subtotal = $800,975 )
2012	2012	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	9	6/15/2012	NON-COMPETING CONTINUATION	$800,975
														Subtotal = $800,975

Issue Date FY: 2011 ( Subtotal = $800,975 )
2011	2011	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	8	7/21/2011	NON-COMPETING CONTINUATION	$800,975
														Subtotal = $800,975

Issue Date FY: 2010 ( Subtotal = $833,308 )
2010	2010	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	7	6/21/2010	NON-COMPETING CONTINUATION	$833,308
														Subtotal = $833,308

Issue Date FY: 2009 ( Subtotal = $841,725 )
2009	2009	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	6	8/26/2009	COMPETING CONTINUATION	$841,725
														Subtotal = $841,725

Issue Date FY: 2008 ( Subtotal = $682,825 ) (Continued on the next page)
Grand Total All Awards = $26,419,117

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Interventions That Retard Mammalian Aging

Award Number: U01AG022308

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2003

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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