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Center for Testing Potential Anti-Aging Interventions

Award Number: U01AG022307
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2004
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Center for Testing Potential Anti-Aging Interventions - PROJECT SUMMARY/ABSTRACT Identification of small molecules that extend mouse lifespan provides new insights into mechanisms of longevity determination in mammals, and may lay the groundwork for eventual anti-aging therapies in humans. The NIA Interventions Testing Program (ITP) evaluates agents proposed to extend mouse lifespan by retardation of aging or postponement of late life diseases. Interventions proposed by multiple collaborating scientists from the research community are tested, in parallel, at three sites (Jackson Laboratories, University of Michigan and University of Texas), using very similar, standardized protocols, and using sufficient numbers of genetically heterogeneous mice to provide 80% power for detecting changes in lifespan of 10%, for either sex, after pooling data from any two of the test sites. One hundred and two such lifespan experiments, involving various doses of 66 distinct agents, have been initiated in the first twenty years of the ITP. Thirty-six experiments have involved comparative tests of multiple doses of effective agents, variable starting ages, or alternative dosing schedules. Statistically significant effects on longevity, in one or both sexes, have been documented and then confirmed for NDGA, rapamycin, acarbose, 17-α-estradiol (17aE2), and canagliflozin. Significant effects were also noted for Protandim, glycine, meclizine, captopril, and astaxanthin. Lifespan trials are now underway for 25 new agents. ITP survival results have also documented longevity benefits from four agents started in middle-age: rapamycin, acarbose, 17aE2, and canagliflozin. A Collaborative Interactions Program (CIP) has provided tissues from ITP drug-treated mice to an open, growing, international network of scientific collaborators, meeting 26 requests from 17 distinct laboratories in the previous five-year period. Plans for the next five-year period include additional lifespan ( Stage 1 ) trials, detailed analyses ( Stage 2 ) of agents found to increase lifespan, transition from the CIP to an Interventions Biospecimens Repository, additional diagnostic specificity in pathological assessments, inclusion of RNA-Seq data in all Stage 2 protocols, and comprehensive pharmacokinetic assessments of drugs found to increase lifespan, as well as continued collaborative work with a network of scientists to study drug effects on postulated aging mechanisms and links to disease. Site-specific Stage 2 studies at UT will add pharmacokinetic analyses in young and old mice, tests to determine mechanisms underlying sex-differences of successful Stage 1 compounds, and tests to determine effects on metabolism of successful Stage 1 compounds. The work proposed should allow the ITP to continue to make major contributions to mammalian aging biology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,515,841 )
2025	2025	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	003	22	6/27/2025	NON-COMPETING CONTINUATION	$1,515,841
2025	2024	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	002	21	3/31/2025	COMPETING CONTINUATION	$3
2025	2024	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	21	3/5/2025	COMPETING CONTINUATION	$0
2025	2023	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	20	3/31/2025	NON-COMPETING CONTINUATION	-$3
														Subtotal = $1,515,841

Issue Date FY: 2024 ( Subtotal = $1,546,778 )
2024	2024	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	002	21	5/30/2024	COMPETING CONTINUATION	$1,546,778
2024	2023	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	20	5/21/2024	NON-COMPETING CONTINUATION	$0
2024	2023	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	20	5/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,546,778

Issue Date FY: 2023 ( Subtotal = $1,521,367 )
2023	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	20	5/1/2023	NON-COMPETING CONTINUATION	$1,521,367
2023	2022	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	19	2/16/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,521,367

Issue Date FY: 2022 ( Subtotal = $1,521,367 )
2022	2022	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	19	5/18/2022	NON-COMPETING CONTINUATION	$1,521,367
2022	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	18	11/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,521,367

Issue Date FY: 2021 ( Subtotal = $1,518,095 )
2021	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	18	4/29/2021	NON-COMPETING CONTINUATION	$1,518,095
2021	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	17	10/27/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,518,095

Issue Date FY: 2020 ( Subtotal = $1,511,552 )
2020	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	004	17	8/10/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	17	5/15/2020	NON-COMPETING CONTINUATION	$1,511,552
2020	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	003	16	5/18/2020	COMPETING CONTINUATION	$198,181
2020	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	002	15	5/18/2020	SUPPLEMENT FOR EXPANSION	-$198,181
2020	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	15	11/8/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,511,552

Issue Date FY: 2019 ( Subtotal = $2,068,866 )
2019	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	006	15	9/18/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	004	16	9/17/2019	COMPETING CONTINUATION	$878,677
2019	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	003	15	9/17/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	15	3/25/2019	SUPPLEMENT FOR EXPANSION	$632,875
2019	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	005	15	9/18/2019	NON-COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	15	7/12/2019	NON-COMPETING CONTINUATION	$557,314
2019	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	002	15	9/17/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,068,866

Issue Date FY: 2018 ( Subtotal = $936,376 )
2018	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	15	5/14/2018	NON-COMPETING CONTINUATION	$936,376
														Subtotal = $936,376

Issue Date FY: 2017 ( Subtotal = $1,493,690 )
2017	2017	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	14	6/23/2017	NON-COMPETING CONTINUATION	$149,369
2017	2017	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	14	5/8/2017	NON-COMPETING CONTINUATION	$1,344,321
														Subtotal = $1,493,690

Issue Date FY: 2016 ( Subtotal = $1,493,690 )
2016	2016	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	13	4/27/2016	NON-COMPETING CONTINUATION	$1,493,690
														Subtotal = $1,493,690

Issue Date FY: 2015 ( Subtotal = $1,448,879 )
2015	2015	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	12	4/30/2015	NON-COMPETING CONTINUATION	$1,448,879
														Subtotal = $1,448,879

Issue Date FY: 2014 ( Subtotal = $1,493,690 )
2014	2014	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	11	8/8/2014	COMPETING CONTINUATION	$1,493,690
														Subtotal = $1,493,690

Issue Date FY: 2013 ( Subtotal = $645,988 )
2013	2013	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	10	7/5/2013	NON-COMPETING CONTINUATION	$645,988
														Subtotal = $645,988

Issue Date FY: 2012 ( Subtotal = $683,586 )
2012	2012	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	9	6/15/2012	NON-COMPETING CONTINUATION	$683,586
														Subtotal = $683,586

Issue Date FY: 2011 ( Subtotal = $683,586 )
2011	2011	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	8	7/21/2011	NON-COMPETING CONTINUATION	$683,586
														Subtotal = $683,586

Issue Date FY: 2010 ( Subtotal = $711,180 ) (Continued on the next page)
Grand Total All Awards = $24,318,325

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Center for Testing Potential Anti-Aging Interventions

Award Number: U01AG022307

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2004

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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