Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Interventions Testing Program at UM

Award Number: U01AG022303
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2003
PERIOD OF PERFORMANCE END DATE: 05/31/2029

Group Awards By:

View Award Description

Interventions Testing Program at UM - ABSTRACT Identification of interventions that extend mouse lifespan provides new insights into mechanisms of longevity determination in mammals, and may lay the groundwork for eventual anti-aging therapies in humans. The NIA Interventions Testing Program (ITP) evaluates agents proposed to extend mouse lifespan by retardation of aging or postponement of late life diseases. Interventions proposed by multiple collaborating scientists from the research community are tested, in parallel, at three sites (Jackson Laboratories, University of Michigan and University of Texas), using very similar, standardized protocols, and using sufficient numbers of genetically heterogeneous mice to provide 80% power for detecting changes in lifespan of 10%, for either sex, after pooling data from any two of the test sites. One hundred and two such lifespan experiments, involving various doses of 66 distinct agents, have been initiated in the first twenty years of the ITP. Thirty-six experiments have involved comparative tests of multiple doses of effective agents, variable starting ages, or alternative dosing schedules. Statistically significant effects on longevity, in one or both sexes, have been documented and then confirmed for NDGA, rapamycin, acarbose, 17-α-estradiol (17aE2), and canagliflozin. Significant effects were also noted for Protandim, glycine, meclizine, captopril, and astaxanthin. Lifespan trials are now underway for 25 new agents. ITP survival results have also documented longevity benefits from four agents started in middle-age: rapamycin, acarbose, 17aE2, and canagliflozin. A Collaborative Interactions Program (CIP) has provided tissues from ITP drug-treated mice to an open, growing, international network of scientific collaborators, meeting 26 requests from 17 distinct laboratories in the previous five-year period. Plans for the next five-year period include additional lifespan ( Stage 1 ) trials, detailed analyses ( Stage 2 ) of agents found to increase lifespan, transition from the CIP to an Interventions Biospecimens Repository, additional diagnostic specificity in pathological assessments, inclusion of RNA-Seq data in all Stage 2 protocols, and comprehensive pharmacokinetic assessments of drugs found to increase lifespan, as well as continued collaborative work with a network of scientists to study drug effects on postulated aging mechanisms and links to disease. Site-specific studies at Michigan will add a battery of tests for Aging Rate Indicators in fat, muscle, brain, plasma, and liver of Stage 2 mice, and include tests of drug effects on learning and memory in Stage 2 protocols. The work proposed should allow the ITP to continue to make major contributions to mammalian aging biology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,502,332 )
2025	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	001	22	6/27/2025	NON-COMPETING CONTINUATION	$1,502,332
2025	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	20	3/18/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,502,332

Issue Date FY: 2024 ( Subtotal = $1,553,900 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	21	5/31/2024	COMPETING CONTINUATION	$1,553,900
														Subtotal = $1,553,900

Issue Date FY: 2023 ( Subtotal = $1,349,571 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	20	3/21/2023	NON-COMPETING CONTINUATION	$1,349,571
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	001	19	4/18/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,349,571

Issue Date FY: 2022 ( Subtotal = $1,382,816 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	001	19	5/11/2022	NON-COMPETING CONTINUATION	$1,382,816
2022	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	18	4/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,382,816

Issue Date FY: 2021 ( Subtotal = $1,407,013 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	18	3/31/2021	NON-COMPETING CONTINUATION	$1,407,013
														Subtotal = $1,407,013

Issue Date FY: 2020 ( Subtotal = $1,441,043 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	001	17	5/15/2020	NON-COMPETING CONTINUATION	$1,441,043
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	004	17	9/2/2020	NON-COMPETING CONTINUATION	$0
2020	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	002	15	5/18/2020	SUPPLEMENT FOR EXPANSION	-$723,077
2020	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	16	2/12/2020	COMPETING CONTINUATION	$0
2020	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	003	16	5/18/2020	COMPETING CONTINUATION	$723,077
														Subtotal = $1,441,043

Issue Date FY: 2019 ( Subtotal = $1,473,243 )
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	001	15	4/5/2019	SUPPLEMENT FOR EXPANSION	$780,000
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	003	15	9/18/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	004	16	9/18/2019	COMPETING CONTINUATION	$693,243
2019	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	002	15	9/18/2019	NON-COMPETING CONTINUATION	$0
2019	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	15	3/15/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,473,243

Issue Date FY: 2018 ( Subtotal = $1,424,681 )
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	15	5/8/2018	NON-COMPETING CONTINUATION	$1,424,681
														Subtotal = $1,424,681

Issue Date FY: 2017 ( Subtotal = $1,458,604 )
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	001	14	6/23/2017	NON-COMPETING CONTINUATION	$145,860
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	14	3/30/2017	NON-COMPETING CONTINUATION	$1,312,744
														Subtotal = $1,458,604

Issue Date FY: 2016 ( Subtotal = $1,481,854 )
2016	2016	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	13	3/31/2016	NON-COMPETING CONTINUATION	$1,481,854
														Subtotal = $1,481,854

Issue Date FY: 2015 ( Subtotal = $1,467,185 )
2015	2015	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	12	5/4/2015	NON-COMPETING CONTINUATION	$1,467,185
														Subtotal = $1,467,185

Issue Date FY: 2014 ( Subtotal = $1,547,230 )
2014	2014	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	001	11	8/18/2014	COMPETING CONTINUATION	$1,547,230
2014	2013	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	10	8/14/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,547,230

Issue Date FY: 2013 ( Subtotal = $576,010 )
2013	2013	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	10	7/5/2013	NON-COMPETING CONTINUATION	$576,010
														Subtotal = $576,010

Issue Date FY: 2012 ( Subtotal = $621,726 )
2012	2012	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	9	6/15/2012	NON-COMPETING CONTINUATION	$621,726
														Subtotal = $621,726

Issue Date FY: 2011 ( Subtotal = $634,160 )
2011	2011	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	8	7/21/2011	NON-COMPETING CONTINUATION	$634,160
														Subtotal = $634,160

Issue Date FY: 2010 ( Subtotal = $659,759 )
2010	2010	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	001	7	6/21/2010	NON-COMPETING CONTINUATION	$659,759
2010	2009	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	6	11/19/2009	COMPETING CONTINUATION	$0
														Subtotal = $659,759

Issue Date FY: 2009 ( Subtotal = $666,424 )
2009	2009	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	6	8/26/2009	COMPETING CONTINUATION	$666,424
														Subtotal = $666,424

Issue Date FY: 2008 ( Subtotal = $585,651 )
2008	2008	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	002	5	8/28/2008	SUPPLEMENT FOR EXPANSION	$585,651
														Subtotal = $585,651

Grand Total All Awards = $23,378,423

Page 1 of 2 (59 items)12

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Interventions Testing Program at UM

Award Number: U01AG022303

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2003

PERIOD OF PERFORMANCE END DATE: 05/31/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer