Wednesday, February 5, 2025 2/5/2025

Detection and Automatic Privacy-Protected Contact Tracing System Designed for COVID-19

Award Number: U01AA029348
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract The COVID-19 pandemic has rapidly spread across the world, bringing death, illness, disruption to daily life, and economic crisis to businesses and individuals. The situation has been exacerbated after the schools and companies reopened due to economic pressure. One of the key failures in COVID-19 containment is underlined by the inability of our healthcare system in real-time detection in point-of-care (POC) and end-user settings and precise tracing with privacy protection of active infections. The fundamental limitations of current gene-based assays stem from their reliance upon amplification and detection of the viral genetic materials even if there were no intact/infectious viruses. These tests require labor-intensive, laboratory-based sample preparation protocols for virus lysis, extraction of genetic materials, purification of the isolated materials, thermal cycling for enzymatic amplification of viral nucleic acid sequences, and interpretation of complex results by professionals. To accurately determine the infectivity of the infected individuals, contaminated objects and environments, and provide guidance for patients, public and authorities to better manage treatment and containment, we seek a new paradigm for rapid and direct pathogen detection and identification in which the intact virions are directly recognized through their distinct surface epitope features, and the resultant fluorescent signal is immediately captured by an end-user smartphone, followed by automatic data transition and event tracing in a blockchain-encrypted manner. To achieve specific recognition of SARS-CoV-2 virions, we customized a designer DNA nanostructure (DDN)-based capture probe that harbors a macromolecular “net” whose vertices precisely match the intra- and inter-spatial pattern of SARS-CoV-2 trimeric spike glycoprotein clusters, and integrates a net-shaped array of SARS-CoV-2 spike specific-targeting aptamers. This aptamer-DDN is designed for maximum affinity and specificity binding with spikes on intact virions in a polyvalent and pattern-matching fashion. Once bound to intact virions, the DNA “nets” trigger the release of fluorescence. This fluorescent signal can be readily and automatically detected by a membrane-shaped and smartphone-based fluorimeter attached to the end-users' phone cameras. The acquired results will be associated with user device IDs that are cyber-protected before tracing. We propose to combine DDN capture probes and a smartphone device to develop and demonstrate a rapid, room temperature, single-step, virus- specific, and ultrasensitive detection of SARS-CoV-2 virus, in which the detection results can be acquired within 5 minutes upon exposure, at the user end, allowing tracing the presence of viruses without affecting user privacy. The signal to result transition, result to ID association, individual track and interacting network tracing will be blockchain-encrypted to ensure information security for individual privacy, while tracing information would be available to health authority for public health benefits.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	001	3	12/1/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2022	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	000	3	12/1/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = -$198 )
2023	2023	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	004	3	2/1/2023	SUPPLEMENT FOR EXPANSION	$487,538
2023	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Alcohol Research Programs	002	2	1/31/2023	SUPPLEMENT FOR EXPANSION	-$487,538
2023	2022	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	003	3	1/31/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$252,631
2023	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Alcohol Research Programs	001	2	1/31/2023	EXTENSION WITH OR WITHOUT FUNDS	-$252,631
2023	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Alcohol Research Programs	006	2	6/20/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
2023	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Alcohol Research Programs	000	2	12/27/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
2023	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Alcohol Research Programs	005	1	6/20/2023	NEW	-$198
														Subtotal = -$198

Issue Date FY: 2022 ( Subtotal = $925,875 )
2022	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Alcohol Research Programs	000	2	12/1/2021	EXTENSION WITH OR WITHOUT FUNDS	$438,337
2022	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Alcohol Research Programs	003	2	8/24/2022	SUPPLEMENT FOR EXPANSION	$487,538
2022	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Alcohol Research Programs	002	1	5/31/2022	NEW	$0
2022	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Alcohol Research Programs	001	1	4/12/2022	NEW	$0
														Subtotal = $925,875

Issue Date FY: 2021 ( Subtotal = $450,305 )
2021	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Alcohol Research Programs	001	1	3/13/2021	NEW	$0
2021	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Alcohol Research Programs	000	1	12/21/2020	NEW	$450,305
														Subtotal = $450,305

Grand Total All Awards = $1,375,982

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Detection and Automatic Privacy-Protected Contact Tracing System Designed for COVID-19

Award Number: U01AA029348

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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