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Minimal False-alarm Touch-based Detection of SARS-Cov-2 Virus Particles using Poly-aptamers

Award Number: U01AA029324
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/21/2020
PERIOD OF PERFORMANCE END DATE: 05/30/2023

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Minimal False-alarm Touch-based Detection of SARS-Cov-2 Virus Particles using Poly-aptamers - PROJECT SUMMARY/ABSTRACT Available tools for detection of SARS-CoV-2 virus require extensive sample preparation and/or expensive lab- based equipment to obtain accurate results. The objective in this proposal is to build a touch-screen sensor array to directly capture, detect, and identify model SARS-CoV-2 virus particles with minimal false alarms. This ambi- tious goal will be achieved by the interdisciplinary team of GE Research scientists and engineers and will be a synergistic combination of the proposed innovations and the prior scientific and engineering accomplishments of the team. Our proposed solution is based on several innovations driven by eliminating a need for a dedicated sam- pling step and solving the problems of detection and reliable selective recognition of virus particles, performing detection/recognition operation in a two-dimensional (2D) format of biosensors, e.g., as a touch-screen surface, and having this technical solution as a low-profile, low power, unobtrusive device that can be adapted to diverse application scenarios. Innovations of the proposed proof-of-principle touch-screen detector are in three main areas. For virus recognition, we will create new multifunctional bioreceptors. Our transduction principle will be based on our earlier reported transduction with the significantly enhanced performance. Our touch surface design will have a 2D array of biosensors. The proposed proof-of-principle sensor will be developed in five aims. Aim 1 will focus on demonstration of new multifunctional bioreceptors. Aim 2 will focus on validation of the functionality of these multifunctional bioreceptors upon their immobilization on sensor surface. Aim 3 will focus on demonstration of sensing of mod- el virus particles in a layout of 2D array of biosensors. Aim 4 will focus on demonstration of virus recognition with immobilized multifunctional bioreceptors in variable ambient conditions. Aim 5 will focus on demonstra- tion of enhanced detection and recognition of model virus particles in the same layout of 2D array of biosensors as in Aim 3, but under variable ambient conditions. The findings in this proposed work will change the state-of- the-art biosensing paradigm and will improve the scientific knowledge, technologies, and workflow practice for virus detection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Alcohol Research Programs	000	2	11/9/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Alcohol Research Programs	001	2	6/14/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
2023	2022	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Alcohol Research Programs	000	2	12/27/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
2023	2021	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Alcohol Research Programs	002	1	6/20/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $599,859 )
2022	2022	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Alcohol Research Programs	000	2	12/1/2021	EXTENSION WITH OR WITHOUT FUNDS	$599,859
2022	2021	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Alcohol Research Programs	001	1	3/4/2022	NEW	$0
2022	2021	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Alcohol Research Programs	002	1	5/16/2022	NEW	$0
														Subtotal = $599,859

Issue Date FY: 2021 ( Subtotal = $581,785 )
2021	2021	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Alcohol Research Programs	001	1	3/12/2021	NEW	$0
2021	2021	GENERAL ELECTRIC COMPANY	1 RESEARCH CIR	NISKAYUNA	NY	12309	SCHENECTADY	USA	Alcohol Research Programs	000	1	12/21/2020	NEW	$581,785
														Subtotal = $581,785

Grand Total All Awards = $1,181,644

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Minimal False-alarm Touch-based Detection of SARS-Cov-2 Virus Particles using Poly-aptamers

Award Number: U01AA029324

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/21/2020

PERIOD OF PERFORMANCE END DATE: 05/30/2023

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