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1/3 Collaborative Research in HIV/AIDS, Alcohol, and Related Comorbidities (COMpAAAS) Tripartite: ART-CC, KP, and VA

Award Number: U01AA026209
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract word count: 424 HIV infected adults who drink are already physiologically frail due to HIV infection, comorbidity (including hepatitis C infection), polypharmacy and associated substance use. In this setting, biomedical consequences of alcohol use can occur with moderate use and are often unappreciated or misattributed. The “Consortium to improve OutcoMes in HIV/Aids, Alcohol, Aging & multi-Substance” (COMpAAAS) is supported by NIH/NIAAA award U24AA020794 to study this issue in a single sample, the Veterans Aging Cohort Study (VACS) (~50,000 HIV+ US veterans demographically matched to ~100,000 uninfected comparators). VACS will employ a direct alcohol biomarker (Phosphatidyl-ethanol (PEth) and a validated measure of physiologic frailty (VACS Index). In this set of three applications, the Antiretroviral Therapy Cohort Collaboration (ART-CC) and Kaiser Permanente (KP) teams join the Veterans Healthcare System (VA) team as COMpAAAS Tripartite: ART-CC, KP, and VA. Our long term goal is to inform alcohol intervention design and implementation. Together we propose to study biomedical consequences of alcohol and associated substance use in HIV extending the scope and generalizability of VACS to multiple healthcare systems in North America and Europe and substantially increasing sample size and diversity of HIV+ subjects. Importantly, COMpAAAS Tripartite also extends uninfected comparators, a critically important group if we are to understand how alcohol may differentially effect biomedical outcomes in HIV. KP will be able to identify appropriate comparators from their Northern California region. A new VA sample of veterans born in 1945-1965 (Birth Cohort) substantially expands access to Hepatitis C infected (HCV+) and women comparators. The tripartite group will also participate in a HIV+ substudy (n=2250), The Medications, Alcohol, Substance Use in HIV Study (MASH), in which new data on potentially inappropriate medications (PIMS) and direct biomarkers for alcohol and associated substances (tobacco, marijuana, opioids, cocaine, and methamphetamine) will be prospectively collected. In initial years, analyses will be conducted using self-report of alcohol and substance use. Limited data sets and uniform methods for data cleaning, standardization, and imputation will be employed across teams. Analyses will be repeated in the final year correcting for biases in self-reported alcohol and substance use based upon MASH results. Consistent with the RFA, all grants contribute data for all aims, have identical aims and protocols, and share data. The VA team will coordinate data sharing and analyses. Each collaborator will be responsible for conducting analyses for one aim. In this application, we will investigate the risk of mortality, hospitalization, and increased physiologic frailty measured by the VACS Index that is attributable to different levels of alcohol use and we will compare these outcomes in HIV-infected and uninfected populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF BRISTOL	BEACON HOUSE	BRISTOL				GBR	Alcohol Research Programs	000	5	9/13/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF BRISTOL	BEACON HOUSE	BRISTOL				GBR	Alcohol Research Programs	000	5	5/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $427,571 )
2021	2021	UNIVERSITY OF BRISTOL	BEACON HOUSE	BRISTOL				GBR	Alcohol Research Programs	000	5	9/17/2021	NON-COMPETING CONTINUATION	$427,571
														Subtotal = $427,571

Issue Date FY: 2020 ( Subtotal = $436,675 )
2020	2020	UNIVERSITY OF BRISTOL	BEACON HOUSE	BRISTOL		BS8 1QU		GBR	Alcohol Research Programs	001	4	8/20/2020	NON-COMPETING CONTINUATION	$436,675
2020	2019	UNIVERSITY OF BRISTOL	BEACON HOUSE	BRISTOL		BS8 1QU		GBR	Alcohol Research Programs	000	3	7/26/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $436,675

Issue Date FY: 2019 ( Subtotal = $444,976 )
2019	2019	UNIVERSITY OF BRISTOL	SENATE HOUSE	BRISTOL	AVON	BS8 1TH		GBR	Alcohol Research Programs	002	3	9/5/2019	NON-COMPETING CONTINUATION	$444,976
2019	2018	UNIVERSITY OF BRISTOL	SENATE HOUSE	BRISTOL	AVON	BS8 1TH		GBR	Alcohol Research Programs	001	2	8/20/2019	NON-COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF BRISTOL	SENATE HOUSE	BRISTOL	AVON	BS8 1TH		GBR	Alcohol Research Programs	000	2	7/31/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $444,976

Issue Date FY: 2018 ( Subtotal = $433,824 )
2018	2018	UNIVERSITY OF BRISTOL	SENATE HOUSE	BRISTOL	AVON	BS8 1TH		GBR	Alcohol Research Programs	001	2	9/12/2018	NON-COMPETING CONTINUATION	$433,824
2018	2017	UNIVERSITY OF BRISTOL	SENATE HOUSE	BRISTOL	AVON	BS8 1TH		GBR	Alcohol Research Programs	000	1	9/6/2018	NEW	$0
														Subtotal = $433,824

Issue Date FY: 2017 ( Subtotal = $456,829 )
2017	2017	UNIVERSITY OF BRISTOL	SENATE HOUSE	BRISTOL	AVON	BS8 1TH		GBR	Alcohol Research Programs	000	1	9/20/2017	NEW	$456,829
														Subtotal = $456,829

Grand Total All Awards = $2,199,875

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1/3 Collaborative Research in HIV/AIDS, Alcohol, and Related Comorbidities (COMpAAAS) Tripartite: ART-CC, KP, and VA

Award Number: U01AA026209

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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