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Immune Dysregulation in FASD: Programming of health and neurobehavioral outcomes

Award Number: U01AA026101
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/20/2017
PERIOD OF PERFORMANCE END DATE: 05/31/2023

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Immune Dysregulation in FASD: Programming of health and neurobehavioral outcomes - Risk for adult diseases or disorders is known to be influenced by the prenatal/early life environment. Building on seminal studies by Barker and colleagues, who reported associations between low birth weight and biological risk for adult disease, support for the “developmental origins of health and disease” (DOHaD) hypothesis has grown to include early life adversities beyond low birth weight and to extend to outcomes beyond metabolic syndrome. Of particular relevance, prenatal alcohol exposure (PAE), in addition to its teratogenic effects, can program developing neurobiological systems and thus increase risk for diseases/ disorders over the life course. Our CIFASD Developmental Project is the first to identify links among maternal alcohol consumption, inflammation, and child outcomes; unique immune signatures in pregnant women were identified in association with whether or not they consumed alcohol and with neurodevelopmental outcomes of their children. The proposed UO1 builds on these findings to examine immune profiles in pregnant women and children from birth through adulthood. Our working hypothesis is that prenatal alcohol-induced dysregulation of immune/ inflammatory systems will be associated with adverse health, functional and adaptive outcomes, providing insight into factors underlying risk and resilience. Specific Aims are to: 1) Use validation cohorts to confirm the utility of immune parameters as possible biomarkers and predictors of alcohol-related health and neurobehavioral outcomes, by analyzing: a) plasma samples and neurobehavioral outcomes from matched mother-infant or mother-child pairs from Ukraine (Chambers) and San Diego (Chambers, Jones, Mattson), respectively, and a child cohort from Minnesota (Wozniak). Assessment of individuals from different cultural/ethnic, SES, and environmental conditions will provide insight into factors modulating alcohol’s programming effects, and increase understanding of immune variables as biomarkers of alcohol intake and predictive factors for PAE-related outcomes. 2) Extend assessment of the immune system into adulthood with assessment of cohorts from Atlanta (Coles), Seattle (Grant), and British Columbia (Weinberg, Loock, Oberlander, Lutke). We will investigate whether physical/mental health and impaired cognitive and adaptive outcomes are associated with immune/inflammatory system dysregulation resulting from prenatal programming effects of alcohol. For both Aims, we will analyze cytokines/inflammatory markers in plasma, obtain past and current mental/physical health information, and measure neurobehavioral and adaptive outcomes, providing novel insight into links among immune function, cognitive and adaptive function, and health outcomes. Together, these studies bring a new dimension to CIFASD, a focus on DOHAD/health outcomes, a critically important but relatively understudied area. Moreover, as the immune system plays a key role in brain development, this work has broad implications for understanding the role of immune/inflammatory mechanisms in FASD-associated neurobehavioral and adaptive deficits.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	THE UNIVERSITY OF BRITISH COLUMBIA	224-6328 MEMORIAL RD	VANCOUVER	BC			CAN	Alcohol Research Programs	001	5	2/9/2024	NON-COMPETING CONTINUATION	$0
2024	2021	THE UNIVERSITY OF BRITISH COLUMBIA	224-6328 MEMORIAL RD	VANCOUVER	BC			CAN	Alcohol Research Programs	000	5	12/29/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $120,080 )
2021	2021	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC			CAN	Alcohol Research Programs	000	5	5/27/2021	NON-COMPETING CONTINUATION	$120,080
														Subtotal = $120,080

Issue Date FY: 2020 ( Subtotal = $148,766 )
2020	2020	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Alcohol Research Programs	001	4	5/15/2020	NON-COMPETING CONTINUATION	$148,766
2020	2019	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Alcohol Research Programs	000	3	1/8/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $148,766

Issue Date FY: 2019 ( Subtotal = $174,587 )
2019	2019	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Alcohol Research Programs	000	3	5/31/2019	NON-COMPETING CONTINUATION	$174,587
														Subtotal = $174,587

Issue Date FY: 2018 ( Subtotal = $178,999 )
2018	2018	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Alcohol Research Programs	000	2	5/16/2018	NON-COMPETING CONTINUATION	$178,999
														Subtotal = $178,999

Issue Date FY: 2017 ( Subtotal = $165,411 )
2017	2017	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Alcohol Research Programs	000	1	7/20/2017	NEW	$165,411
														Subtotal = $165,411

Grand Total All Awards = $787,843

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Immune Dysregulation in FASD: Programming of health and neurobehavioral outcomes

Award Number: U01AA026101

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/20/2017

PERIOD OF PERFORMANCE END DATE: 05/31/2023

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