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Southern California Alcoholic Hepatitis Consortium Administrative Core

Award Number: U01AA021884
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2013
PERIOD OF PERFORMANCE END DATE: 08/31/2018

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Southern California Alcoholic Hepatitis Consortium Administrative Core - DESCRIPTION (provided by applicant): Alcoholic hepatitis is an inflammatory disease of the liver that occurs for unknown reasons in a minority of chronic alcoholic patients. The pathophysiology of alcoholic hepatitis is incompletely understood and prednisolone, the recommended treatment for severe alcoholic hepatitis, is ineffective in a significant proportion of patients. Improvements in alcoholic hepatitis will require testing of new drugs and detailed investigations of liver and blood using broad, hypothesis independent approaches (e.g., proteomics and transcriptomics) as well as focused, hypothesis driven investigations. The overall aims of the administrative core are to provide administrative support for the scientific missions and specific aims of the individual U01 projects, to assist the External Advisory Board with oversight of the consortium, and to ensure the objectives of the NIAAA are achieved. In particular, this consortium is focused on understanding and treating hepatic inflammation and exploring pathways of hepatocyte injury and regeneration in alcoholic hepatitis. The main project in the consortium is a clinical trial of new treatments for alcoholic hepatitis. The five oher translational projects will explore immune status, transcriptomics of the liver, proteomics of the liver, hepatocyte mitochondrial damage, pathways of hepatocyte injury, and inhibition of hepatocyte regeneration. Collaboration among projects is central to understanding the pathophysiology of alcoholic hepatitis. The administrative core will be responsible for oversight of the projects, encouraging collaboration, monitoring progress of individual projects, resolving conflicts, evaluating the addition of new investigators, responding to scientific inquiries relatedto the research, and maintaining communication with the NIAAA. This U01 consortium and the administrative core support the NIAAA's mission of understanding the health effects of alcohol, including the pathophysiology and treatment of alcoholic liver injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = -$88,158 )
2019	2016	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION	5901 E 7TH ST 151	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	000	4	12/31/2018	EXTENSION WITH OR WITHOUT FUNDS	-$88,158
														Subtotal = -$88,158

Issue Date FY: 2018 ( Subtotal = -$26,862 )
2018	2017	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION	5901 E 7TH ST 151	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	000	5	9/30/2018	NON-COMPETING CONTINUATION	-$26,862
														Subtotal = -$26,862

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2017	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION	5901 E 7TH ST 151	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	004	5	9/8/2017	NON-COMPETING CONTINUATION	$0
2017	2016	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION	5901 E 7TH ST 151	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	003	4	8/24/2017	EXTENSION WITH OR WITHOUT FUNDS	$86,550
2017	2015	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION	5901 E 7TH ST 151	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	002	3	8/24/2017	NON-COMPETING CONTINUATION	-$29,086
2017	2014	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION	5901 E 7TH ST 151	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	001	2	8/24/2017	NON-COMPETING CONTINUATION	-$29,086
2017	2013	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION	5901 E 7TH ST 151	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	000	1	8/24/2017	NEW	-$28,378
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $29,986 )
2016	2016	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH & EDUCATION	5901 EAST SEVENTH STREET	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	000	4	8/15/2016	EXTENSION WITH OR WITHOUT FUNDS	$29,986
														Subtotal = $29,986

Issue Date FY: 2015 ( Subtotal = $29,086 )
2015	2015	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH & EDUCATION	5901 EAST SEVENTH STREET	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	000	3	8/19/2015	NON-COMPETING CONTINUATION	$29,086
														Subtotal = $29,086

Issue Date FY: 2014 ( Subtotal = $29,424 )
2014	2014	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH & EDUCATION	5901 EAST SEVENTH STREET	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	001	2	8/1/2014	NON-COMPETING CONTINUATION	$29,086
2014	2013	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH & EDUCATION	5901 EAST SEVENTH STREET	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	000	1	4/8/2014	NEW	$338
														Subtotal = $29,424

Issue Date FY: 2013 ( Subtotal = $29,986 )
2013	2013	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH & EDUCATION	5901 EAST SEVENTH STREET	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	001	1	4/8/2014	NEW	$338
2013	2013	SOUTHERN CALIFORNIA INSTITUTE FOR RESEARCH & EDUCATION	5901 EAST SEVENTH STREET	LONG BEACH	CA	90822	LOS ANGELES	USA	Alcohol Research Programs	000	1	9/19/2013	NEW	$29,648
														Subtotal = $29,986

Grand Total All Awards = $3,462

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Southern California Alcoholic Hepatitis Consortium Administrative Core

Award Number: U01AA021884

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2013

PERIOD OF PERFORMANCE END DATE: 08/31/2018

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