Thursday, November 21, 2024 11/21/2024

National Consortium on Alcohol and NeuroDevelopment in Adolescence - SRI International Research Project Site (NCANDA-SRI)

Award Number: U01AA021696
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY / ABSTRACT Initiating excessive alcohol drinking during adolescence is known to disturb typical neurodevelopmental patterns, increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood. In response to RFA-AA-21-007, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a diverse community sample of male and female participants recruited in three age bands (12-14, 15-17, 18-21 years old) when most were no-to-low drinkers and tracked over the last 8 years across 5 sites (N=831; 93% retention rate). Monitoring has involved annually acquired multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep and physical activity tracking. This cohort sequential design uniquely positions NCANDA-A to quantify transient or enduring alcohol-related disturbances in specific adolescent and early adult neural system growth trajectories and functional concomitants. NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, NCANDA-A will investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on subsequent developmental trajectories of cognitive performance, brain structure and function, and psychopathology. Aim 2 analyses will identify neurodevelopment patterns describing the extent to which alcohol's effects on brain structure and function resolve or persist during desistance after binge drinking. Aim 3 will deploy data-driven analysis to identify adolescent biological, environmental, and behavioral factors (e.g., age of drinking onset) that forecast excessive drinking during early adulthood. In Aim 4, NCANDA-A will quantify the impact of the COVID pandemic on life stress and social, emotional, and economic wellbeing and their relations with alcohol use patterns. In Aim 5, the SRI and Pittsburgh sites will identify interactions among patterns of alcohol use, sleep, and cardiac function. In Aim 6, the UCSD, Duke and OHSU sites will determine the extent to which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect, sleep and resting heart rate, and reversal of the adverse structural and functional brain effects of frequent binge alcohol use. For each aim, sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors will be tested. With the longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel information to the public on the enduring and transient effects of adolescent drinking on adult functioning by discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $757,014 )
2024	2024	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	001	13	9/18/2024	SUPPLEMENT FOR EXPANSION	$98,534
2024	2024	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	13	8/14/2024	NON-COMPETING CONTINUATION	$658,480
														Subtotal = $757,014

Issue Date FY: 2023 ( Subtotal = $658,615 )
2023	2023	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	004	12	6/7/2023	NON-COMPETING CONTINUATION	$658,615
2023	2022	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	11	1/25/2023	COMPETING CONTINUATION	$0
2023	2022	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	003	11	5/8/2023	COMPETING CONTINUATION	$128,555
2023	2021	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	001	10	5/8/2023	NON-COMPETING CONTINUATION	-$101,452
2023	2021	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	002	10	5/8/2023	SUPPLEMENT FOR EXPANSION	-$27,104
														Subtotal = $658,615

Issue Date FY: 2022 ( Subtotal = $658,709 )
2022	2022	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	11	8/4/2022	COMPETING CONTINUATION	$658,709
														Subtotal = $658,709

Issue Date FY: 2021 ( Subtotal = $931,547 )
2021	2021	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	001	10	6/15/2021	NON-COMPETING CONTINUATION	$735,146
2021	2021	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	003	10	7/22/2021	SUPPLEMENT FOR EXPANSION	$196,401
2021	2021	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	002	10	6/28/2021	NON-COMPETING CONTINUATION	$0
2021	2020	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	9	1/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $931,547

Issue Date FY: 2020 ( Subtotal = $961,804 )
2020	2020	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	001	9	9/1/2020	SUPPLEMENT FOR EXPANSION	$198,581
2020	2020	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	9	6/9/2020	NON-COMPETING CONTINUATION	$763,223
														Subtotal = $961,804

Issue Date FY: 2019 ( Subtotal = $787,147 )
2019	2019	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	8	6/28/2019	NON-COMPETING CONTINUATION	$787,147
														Subtotal = $787,147

Issue Date FY: 2018 ( Subtotal = $960,552 )
2018	2018	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	003	7	8/29/2018	SUPPLEMENT FOR EXPANSION	$150,338
2018	2018	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	002	7	6/27/2018	NON-COMPETING CONTINUATION	$810,214
2018	2017	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	001	6	1/29/2018	COMPETING CONTINUATION	$111,488
2018	2016	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	5	1/29/2018	EXTENSION WITH OR WITHOUT FUNDS	-$111,488
														Subtotal = $960,552

Issue Date FY: 2017 ( Subtotal = $834,033 )
2017	2017	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	002	6	6/29/2017	COMPETING CONTINUATION	$834,033
2017	2016	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	001	5	12/2/2016	EXTENSION WITH OR WITHOUT FUNDS	$13,472
2017	2015	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	4	12/2/2016	NON-COMPETING CONTINUATION	-$13,472
														Subtotal = $834,033

Issue Date FY: 2016 ( Subtotal = $905,224 )
2016	2016	STANFORD RESEARCH INSTITUTE INTERNATIONAL	333 RAVENSWOOD AVENUE, AG139	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	5	6/23/2016	EXTENSION WITH OR WITHOUT FUNDS	$905,224
														Subtotal = $905,224

Issue Date FY: 2015 ( Subtotal = $864,787 )
2015	2015	STANFORD RESEARCH INSTITUTE INTERNATIONAL	333 RAVENSWOOD AVENUE, AG139	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	4	5/15/2015	NON-COMPETING CONTINUATION	$864,787
														Subtotal = $864,787

Issue Date FY: 2014 ( Subtotal = $870,445 )
2014	2014	STANFORD RESEARCH INSTITUTE INTERNATIONAL	333 RAVENSWOOD AVENUE, AG139	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	3	6/30/2014	NON-COMPETING CONTINUATION	$870,445
														Subtotal = $870,445

Issue Date FY: 2013 ( Subtotal = $825,981 )
2013	2013	STANFORD RESEARCH INSTITUTE INTERNATIONAL	333 RAVENSWOOD AVENUE, AG139	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	2	7/3/2013	NON-COMPETING CONTINUATION	$825,981
														Subtotal = $825,981

Issue Date FY: 2012 ( Subtotal = $894,249 )
2012	2012	STANFORD RESEARCH INSTITUTE INTERNATIONAL	333 RAVENSWOOD AVENUE, AG139	MENLO PARK	CA	94025	SAN MATEO	USA	Alcohol Research Programs	000	1	9/4/2012	NEW	$894,249
														Subtotal = $894,249

Grand Total All Awards = $10,910,107

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National Consortium on Alcohol and NeuroDevelopment in Adolescence - SRI International Research Project Site (NCANDA-SRI)

Award Number: U01AA021696

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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