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2/11 Spatially Resolved, Single Cell, Neuroimmune Transcriptomes in Alcohol Dependence

Award Number: U01AA020926
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/05/2011
PERIOD OF PERFORMANCE END DATE: 01/31/2027

Group Awards By:

View Award Description

2/11 Spatially Resolved, Single Cell, Neuroimmune Transcriptomes in Alcohol Dependence - Project Summary/Abstract Neuroimmune signaling is strongly implicated in the development and progression of alcohol use disorder (AUD). Innate immune molecules are upregulated in human postmortem brains from alcoholics and are correlated with lifetime alcohol use. Human genome-wide association studies (GWAS) also link immune/inflammatory genes to alcohol dependence. We hypothesize that alcohol consumption initiates a positive feedback loop involving neuroimmune activation and proinflammatory responses that promote excessive alcohol consumption. Neuroimmune signaling also regulates voluntary alcohol consumption in rodent models and activation of specific pathways results in escalation of drinking. Our recent work shows that immune signaling in glial cells have emerged as key regulators of alcohol drinking. Using single cell and spatial transcriptome technologies, we are now able to precisely define the role of individual types of brain cells in the context of excessive alcohol consumption. Our overarching hypothesis is phenotypic changes characteristic of escalated alcohol consumption and preference are due, in part, to spatially distinct and cell-specific molecular mechanisms that significantly reshape the neuroimmune transcriptome. Multi-omic genetic changes at the cellular level from human and animal models will reveal new gene candidates and therapeutic targets.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $545,194 )
2026	2026	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	15	2/6/2026	NON-COMPETING CONTINUATION	$545,194
														Subtotal = $545,194

Issue Date FY: 2025 ( Subtotal = $545,194 )
2025	2025	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	14	3/5/2025	NON-COMPETING CONTINUATION	$490,675
2025	2025	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	001	14	8/4/2025	NON-COMPETING CONTINUATION	$54,519
														Subtotal = $545,194

Issue Date FY: 2024 ( Subtotal = $545,194 )
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	13	1/23/2024	NON-COMPETING CONTINUATION	$490,675
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	001	13	5/21/2024	NON-COMPETING CONTINUATION	$54,519
														Subtotal = $545,194

Issue Date FY: 2023 ( Subtotal = $545,194 )
2023	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	12	1/28/2023	NON-COMPETING CONTINUATION	$545,194
														Subtotal = $545,194

Issue Date FY: 2022 ( Subtotal = $575,194 )
2022	2022	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	003	11	7/11/2022	COMPETING CONTINUATION	$64,584
2022	2022	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	11	2/10/2022	COMPETING CONTINUATION	$575,194
2022	2022	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	001	11	3/22/2022	COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	002	10	7/11/2022	NON-COMPETING CONTINUATION	-$64,584
														Subtotal = $575,194

Issue Date FY: 2021 ( Subtotal = $428,932 )
2021	2021	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	10	1/15/2021	NON-COMPETING CONTINUATION	$428,932
														Subtotal = $428,932

Issue Date FY: 2020 ( Subtotal = $428,932 )
2020	2020	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	9	1/22/2020	NON-COMPETING CONTINUATION	$428,932
														Subtotal = $428,932

Issue Date FY: 2019 ( Subtotal = $428,932 )
2019	2019	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	8	1/24/2019	NON-COMPETING CONTINUATION	$428,932
														Subtotal = $428,932

Issue Date FY: 2018 ( Subtotal = $428,932 )
2018	2018	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	004	7	9/20/2018	NON-COMPETING CONTINUATION	$0
2018	2018	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	003	7	5/23/2018	NON-COMPETING CONTINUATION	$42,894
2018	2018	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	7	1/29/2018	NON-COMPETING CONTINUATION	$386,038
2018	2017	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	001	6	2/22/2018	COMPETING CONTINUATION	$35,129
2018	2016	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	002	5	2/22/2018	SUPPLEMENT FOR EXPANSION	-$35,129
														Subtotal = $428,932

Issue Date FY: 2017 ( Subtotal = $445,995 )
2017	2017	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	002	6	6/7/2017	COMPETING CONTINUATION	$1,337
2017	2017	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	004	6	8/18/2017	COMPETING CONTINUATION	$445,995
2017	2017	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	003	6	8/2/2017	COMPETING CONTINUATION	-$445,995
2017	2017	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	6	2/1/2017	COMPETING CONTINUATION	$445,995
2017	2015	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	001	5	6/7/2017	SUPPLEMENT FOR EXPANSION	-$1,337
														Subtotal = $445,995

Issue Date FY: 2016 ( Subtotal = $121,952 )
2016	2016	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Alcohol Research Programs	000	5	8/26/2016	SUPPLEMENT FOR EXPANSION	$121,952
2016	2015	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Alcohol Research Programs	001	5	8/26/2016	NON-COMPETING CONTINUATION	$0
2016	2015	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Alcohol Research Programs	002	5	8/26/2016	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $121,952

Issue Date FY: 2015 ( Subtotal = $488,326 )
2015	2015	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Alcohol Research Programs	001	5	9/14/2015	SUPPLEMENT FOR EXPANSION	$195,640
2015	2015	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Alcohol Research Programs	000	5	8/7/2015	NON-COMPETING CONTINUATION	$292,686
														Subtotal = $488,326

Issue Date FY: 2014 ( Subtotal = $292,686 )
2014	2014	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Alcohol Research Programs	000	4	8/15/2014	NON-COMPETING CONTINUATION	$292,686
														Subtotal = $292,686

Issue Date FY: 2013 ( Subtotal = $280,617 )
2013	2013	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Alcohol Research Programs	000	3	8/12/2013	NON-COMPETING CONTINUATION	$280,617
														Subtotal = $280,617

Issue Date FY: 2012 ( Subtotal = $300,762 )
2012	2012	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Alcohol Research Programs	000	2	8/15/2012	NON-COMPETING CONTINUATION	$300,762
														Subtotal = $300,762

Issue Date FY: 2011 ( Subtotal = $300,762 )
2011	2011	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Alcohol Research Programs	000	1	9/5/2011	NEW	$300,762
														Subtotal = $300,762

Grand Total All Awards = $6,702,798

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2/11 Spatially Resolved, Single Cell, Neuroimmune Transcriptomes in Alcohol Dependence

Award Number: U01AA020926

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/05/2011

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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