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2/8 NADIA U01 Adolescent Alcohol Exposure: Neural Contributors to Sex- and Exposure Timing-Specific Anxiety

Award Number: U01AA019972
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/05/2010
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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2/8 NADIA U01 Adolescent Alcohol Exposure: Neural Contributors to Sex- and Exposure Timing-Specific Anxiety - Project Summary Our current work in the NIAAA consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) has revealed that long-lasting behavioral consequences of adolescent intermittent ethanol exposure (AIE) are sex- and exposure timing-dependent. When tested in adulthood, only male rats exposed to ethanol during early-mid adolescence (early AIE) demonstrate social alterations that include social anxiety and enhanced sensitivity to ethanol-induced social facilitation, with exposure to ethanol later in adolescence (late AIE) having no such consequences. Our most important translational finding is that a selective oxytocin receptor (OXTR) agonist reverses the male-specific social anxiety. At the cellular and molecular levels, sex-specific consequences of early AIE are evident as alterations in dendritic spine morphology and decreases in OXTR mRNA and protein expression in the hypothalamus. Our current proposal will address critical gaps arising from this work. Aim 1 will identify socially relevant regions differentially activated in adult males and females by social stimuli following early AIE and will test whether recruitment of neuronal ensembles in identified brain regions is required for male-specific social affective alterations. Aim 2 will further assess AIE-induced alterations of the OXT system contributing to male-specific social anxiety and will investigate neural mechanisms underlying the reversal effects of OXTR pharmacological activation. Aim 3 is designed to test whether AIE selectively disrupts epigenetic regulation of the OXT neuromodulatory peptide system in brain regions critical for normal social functioning.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $391,360 )
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	000	15	8/6/2024	NON-COMPETING CONTINUATION	$391,360
														Subtotal = $391,360

Issue Date FY: 2023 ( Subtotal = $391,360 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	000	14	8/31/2023	NON-COMPETING CONTINUATION	$391,360
														Subtotal = $391,360

Issue Date FY: 2022 ( Subtotal = $391,360 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	001	13	8/19/2022	NON-COMPETING CONTINUATION	$391,360
2022	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	000	10	8/11/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $391,360

Issue Date FY: 2021 ( Subtotal = $391,360 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	002	12	8/19/2021	NON-COMPETING CONTINUATION	$391,360
2021	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	001	11	2/9/2021	COMPETING CONTINUATION	$2,789
2021	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	000	10	2/9/2021	NON-COMPETING CONTINUATION	-$2,789
														Subtotal = $391,360

Issue Date FY: 2020 ( Subtotal = $391,360 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	000	11	7/31/2020	COMPETING CONTINUATION	$391,360
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	001	11	9/15/2020	COMPETING CONTINUATION	$0
														Subtotal = $391,360

Issue Date FY: 2019 ( Subtotal = $348,302 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	000	10	8/16/2019	NON-COMPETING CONTINUATION	$348,302
														Subtotal = $348,302

Issue Date FY: 2018 ( Subtotal = $348,302 )
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	000	9	8/29/2018	NON-COMPETING CONTINUATION	$348,302
														Subtotal = $348,302

Issue Date FY: 2017 ( Subtotal = $348,302 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Alcohol Research Programs	000	8	8/3/2017	NON-COMPETING CONTINUATION	$348,302
														Subtotal = $348,302

Issue Date FY: 2016 ( Subtotal = $348,302 )
2016	2016	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Alcohol Research Programs	000	7	7/29/2016	NON-COMPETING CONTINUATION	$348,302
														Subtotal = $348,302

Issue Date FY: 2015 ( Subtotal = $348,302 )
2015	2015	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Alcohol Research Programs	000	6	8/27/2015	COMPETING CONTINUATION	$348,302
														Subtotal = $348,302

Issue Date FY: 2014 ( Subtotal = $322,237 )
2014	2014	SUNY, BINGHAMTON	VESTAL PARKWAY, EAST	BINGHAMTON	NY	13901	BROOME	USA	Alcohol Research Programs	000	5	7/31/2014	NON-COMPETING CONTINUATION	$322,237
														Subtotal = $322,237

Issue Date FY: 2013 ( Subtotal = $313,257 )
2013	2013	SUNY, BINGHAMTON	VESTAL PARKWAY, EAST	BINGHAMTON	NY	13901	BROOME	USA	Alcohol Research Programs	000	4	8/9/2013	NON-COMPETING CONTINUATION	$313,257
														Subtotal = $313,257

Issue Date FY: 2012 ( Subtotal = $341,789 )
2012	2012	SUNY, BINGHAMTON	VESTAL PARKWAY, EAST	BINGHAMTON	NY	13901	BROOME	USA	Alcohol Research Programs	000	3	8/15/2012	NON-COMPETING CONTINUATION	$341,789
														Subtotal = $341,789

Issue Date FY: 2011 ( Subtotal = $344,217 )
2011	2011	SUNY, BINGHAMTON	VESTAL PARKWAY, EAST	BINGHAMTON	NY	13901	BROOME	USA	Alcohol Research Programs	000	2	8/16/2011	NON-COMPETING CONTINUATION	$344,217
														Subtotal = $344,217

Issue Date FY: 2010 ( Subtotal = $369,769 )
2010	2010	SUNY, BINGHAMTON	VESTAL PARKWAY, EAST	BINGHAMTON	NY	13901	BROOME	USA	Alcohol Research Programs	000	1	9/3/2010	NEW	$369,769
														Subtotal = $369,769

Grand Total All Awards = $5,389,579

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2/8 NADIA U01 Adolescent Alcohol Exposure: Neural Contributors to Sex- and Exposure Timing-Specific Anxiety

Award Number: U01AA019972

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/05/2010

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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