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Defining Translational Approaches for the Image-based Detection of Prenatal Alcohol Exposure

Award Number: U01AA014809
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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As a constituent component of CIFASD5, this project will focus on improving the identification of individuals with prenatal alcohol exposure (PAE), across the lifespan, with the primary goal of translation for clinical application. We target two main categories outlined in the Request for Application (RFA) 1. To identify FASD cases early and accurately, and 2. To expand and translate basic and mechanistic understandings of the effects of PAE. To address these topics, we aim to improve the accuracy and reliability of the clinical recognition of FASD, controlling for the influence of sex, co- exposures, and age. We seek to understand better how neurocognitive and facial morphology are correlative and covariant in FASD and exploit this relationship to improve screening accuracy. Previously, we have implemented methods and associated software for analyzing face shape and face - brain-cognitive relationships to detect the effects of PAE. In doing so, we have created an effective toolkit to automatically and objectively identify cardinal and subtle PAE-associated facial dysmorphism across the FASD spectrum. It is now a priority to refine and optimize our methods, utilizing low-cost 3D imaging devices to validate and distribute to the clinical community. To accomplish our goals, we propose to follow specific aims: 1. Explore the impact of factors secondary to alcohol exposure that may influence facial morphology; 2. Detect facial, cranial, and neural effects of prenatal alcohol exposure across the lifespan; 3. Develop, test, and validate automated methods for FASD screening, integrating neurocognitive assessment tools and distributing to the clinical community. Achieving aims 1 and 2 will dramatically refine FASD recognition by understanding the factors secondary to alcohol that may influence outcomes across the lifespan. Successful demonstration of aim 2 will achieve the earliest possible diagnosis enabling further research and feedback for intervention studies and also focus on recognizing traits in adults - a population significantly underreported in the literature. Ultimately, aim 3 encompasses the primary goal of the project, developing, testing, and validating multi-domain screening tools that assist with clinical identification. We will work closely with consortium partners who will recruit subjects and provide facial images and neurocognitive assessment data (U01: Chambers; U01: Coles & Weinberg; U01: Wozniak; U01: DiClemente; U01: Petrenko). Particularly close collaboration is required for the face-neurocognitive analysis, where we will integrate and combine facial and neurocognitive screening tools (U01: Mattson). We will rely on research resources for data management (R24: Wetherill) and to validate screening tools and gain clinical feedback (R24: Del Campo).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $207,399 )
2024	2024	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD				GBR	Alcohol Research Programs	000	21	5/16/2024	NON-COMPETING CONTINUATION	$207,399
														Subtotal = $207,399

Issue Date FY: 2023 ( Subtotal = $252,399 )
2023	2023	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD				GBR	Alcohol Research Programs	000	20	5/3/2023	NON-COMPETING CONTINUATION	$252,399
														Subtotal = $252,399

Issue Date FY: 2022 ( Subtotal = $239,399 )
2022	2022	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE			GBR	Alcohol Research Programs	001	19	8/15/2022	COMPETING CONTINUATION	$239,399
2022	2021	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE			GBR	Alcohol Research Programs	002	18	8/17/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE			GBR	Alcohol Research Programs	000	18	4/4/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $239,399

Issue Date FY: 2021 ( Subtotal = $225,264 )
2021	2021	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE			GBR	Alcohol Research Programs	001	18	6/3/2021	NON-COMPETING CONTINUATION	$225,264
2021	2020	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE			GBR	Alcohol Research Programs	000	17	2/25/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $225,264

Issue Date FY: 2020 ( Subtotal = $234,498 )
2020	2020	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE	OX1 2JD		GBR	Alcohol Research Programs	000	17	5/29/2020	NON-COMPETING CONTINUATION	$234,498
														Subtotal = $234,498

Issue Date FY: 2019 ( Subtotal = $325,174 )
2019	2019	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE	OX1 2JD		GBR	Alcohol Research Programs	001	16	5/9/2019	NON-COMPETING CONTINUATION	$228,537
2019	2019	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE	OX1 2JD		GBR	Alcohol Research Programs	002	16	5/22/2019	SUPPLEMENT FOR EXPANSION	$96,641
2019	2018	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE	OX1 2JD		GBR	Alcohol Research Programs	000	15	2/15/2019	NON-COMPETING CONTINUATION	$0
2019	2015	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	003	12	6/24/2019	NON-COMPETING CONTINUATION	-$4
														Subtotal = $325,174

Issue Date FY: 2018 ( Subtotal = $262,336 )
2018	2018	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE	OX1 2JD		GBR	Alcohol Research Programs	004	15	8/24/2018	NON-COMPETING CONTINUATION	$0
2018	2018	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE	OX1 2JD		GBR	Alcohol Research Programs	003	15	5/16/2018	NON-COMPETING CONTINUATION	$262,337
2018	2017	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE	OX1 2JD		GBR	Alcohol Research Programs	002	14	2/21/2018	COMPETING CONTINUATION	$29,007
2018	2016	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	13	2/21/2018	EXTENSION WITH OR WITHOUT FUNDS	-$29,007
2018	2016	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	13	10/18/2017	EXTENSION WITH OR WITHOUT FUNDS	-$1
														Subtotal = $262,336

Issue Date FY: 2017 ( Subtotal = $288,909 )
2017	2017	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE	OX1 2JD		GBR	Alcohol Research Programs	001	14	7/6/2017	COMPETING CONTINUATION	$288,909
2017	2016	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	13	7/3/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $288,909

Issue Date FY: 2016 ( Subtotal = $289,568 )
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	13	5/10/2016	EXTENSION WITH OR WITHOUT FUNDS	$289,568
														Subtotal = $289,568

Issue Date FY: 2015 ( Subtotal = $302,294 )
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	12	4/30/2015	NON-COMPETING CONTINUATION	$302,294
														Subtotal = $302,294

Issue Date FY: 2014 ( Subtotal = $301,422 )
2014	2014	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	11	5/21/2014	NON-COMPETING CONTINUATION	$301,422
														Subtotal = $301,422

Issue Date FY: 2013 ( Subtotal = $303,043 )
2013	2013	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	10	5/31/2013	NON-COMPETING CONTINUATION	$303,043
														Subtotal = $303,043

Issue Date FY: 2012 ( Subtotal = $372,560 )
2012	2012	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	9	8/9/2012	COMPETING CONTINUATION	$372,560
														Subtotal = $372,560

Issue Date FY: 2011 ( Subtotal = $239,727 )
2011	2011	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	8	8/5/2011	NON-COMPETING CONTINUATION	$239,727
														Subtotal = $239,727

Issue Date FY: 2010 ( Subtotal = $422,081 )
2010	2010	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	002	7	9/25/2010	SUPPLEMENT FOR EXPANSION	$123,200
2010	2010	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	001	7	8/10/2010	NON-COMPETING CONTINUATION	$298,881
2010	2009	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	6	3/30/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $422,081

Issue Date FY: 2009 ( Subtotal = $295,163 )
2009	2009	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	6	8/18/2009	NON-COMPETING CONTINUATION	$295,163
														Subtotal = $295,163

Issue Date FY: 2008 ( Subtotal = $495,172 )
2008	2008	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	001	5	8/25/2008	SUPPLEMENT FOR EXPANSION	$153,230
2008	2008	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	5	8/18/2008	NON-COMPETING CONTINUATION	$341,942
														Subtotal = $495,172

Issue Date FY: 2007 ( Subtotal = $359,361 )
2007	2007	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	4	9/29/2007	OTHER REVISION	$359,361
														Subtotal = $359,361

Grand Total All Awards = $5,415,769

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Defining Translational Approaches for the Image-based Detection of Prenatal Alcohol Exposure

Award Number: U01AA014809

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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