Tuesday, July 1, 2025 7/1/2025

6/8: INIA Stress and Chronic Alcohol Interactions: Stress and Ethanol Self Administration in Monkeys

Award Number: U01AA013510
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2002
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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6/8: INIA Stress and Chronic Alcohol Interactions: Stress and Ethanol Self Administration in Monkeys - PROJECT SUMMARY Chronic, heavy alcohol consumption leads to a disruption of stress homeostasis and a feed-forward cycle of alcohol-stress interactions that further exacerbate alcohol drinking. The rhesus monkey model of alcohol self- administration has documented allostatic changes within key brain areas associated with chronic heavy alcohol drinking. These include hypothalamic control of the stress axis and the dorsal striatum (caudate and putamen) implicated in control of action selection. Specifically, the striatal and HPA axis neuroadaptations were associated with an increase in alcohol drinking during relapse, deficits in flexibility in action selection and shift in the excitatory-to-inhibitory balance favoring the sensorimotor neurocircuitry. The proposed studies will exploit individual differences in stress regulation and behavioral flexibility to identify mechanisms underlying excessive drinking and susceptibility to relapse. The integrative designs encompass: self-administration with repeated abstinence/relapse cycles in rhesus monkeys; longitudinal measures of flexibility in action selection, stress response and integrity of brain neurocircuitry using rs-fMRI; manipulating cortico-dorsostriatal circuits in primate brain using designer receptors exclusively activated by designer drug (DREADDs) to alter ethanol drinking, behavioral flexibility and stress response. Ultimately, this project aims to define the role of cortico-striatal circuitry in protecting or facilitating excessive alcohol drinking. The research will also contribute to emerging sex differences in the stress response to chronic drinking through a balanced sex design.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $549,967 )
2025	2025	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	25	3/20/2025	NON-COMPETING CONTINUATION	$549,967
														Subtotal = $549,967

Issue Date FY: 2024 ( Subtotal = $612,200 )
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	002	24	5/30/2024	NON-COMPETING CONTINUATION	$0
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	24	1/18/2024	NON-COMPETING CONTINUATION	$550,980
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	24	5/16/2024	NON-COMPETING CONTINUATION	$61,220
														Subtotal = $612,200

Issue Date FY: 2023 ( Subtotal = $612,415 )
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	23	1/30/2023	NON-COMPETING CONTINUATION	$612,415
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	23	7/25/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $612,415

Issue Date FY: 2022 ( Subtotal = $611,814 )
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	22	3/11/2022	COMPETING CONTINUATION	$611,814
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	002	22	3/22/2022	COMPETING CONTINUATION	$0
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	004	22	4/13/2022	COMPETING CONTINUATION	$325
2022	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	003	21	4/13/2022	NON-COMPETING CONTINUATION	-$325
2022	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	21	3/8/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $611,814

Issue Date FY: 2021 ( Subtotal = $450,678 )
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	21	2/15/2021	NON-COMPETING CONTINUATION	$450,678
														Subtotal = $450,678

Issue Date FY: 2020 ( Subtotal = $449,285 )
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	20	1/28/2020	NON-COMPETING CONTINUATION	$449,285
														Subtotal = $449,285

Issue Date FY: 2019 ( Subtotal = $441,039 )
2019	2019	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	19	1/24/2019	NON-COMPETING CONTINUATION	$441,039
														Subtotal = $441,039

Issue Date FY: 2018 ( Subtotal = $449,285 )
2018	2018	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	18	1/18/2018	NON-COMPETING CONTINUATION	$404,356
2018	2018	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	18	5/23/2018	NON-COMPETING CONTINUATION	$44,929
														Subtotal = $449,285

Issue Date FY: 2017 ( Subtotal = $450,679 )
2017	2017	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	002	17	5/12/2017	COMPETING CONTINUATION	$325
2017	2017	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	17	1/31/2017	COMPETING CONTINUATION	$450,679
2017	2016	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	16	5/12/2017	EXTENSION WITH OR WITHOUT FUNDS	-$325
														Subtotal = $450,679

Issue Date FY: 2016 ( Subtotal = $480,116 )
2016	2016	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	16	1/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$480,116
														Subtotal = $480,116

Issue Date FY: 2015 ( Subtotal = $497,810 )
2015	2015	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	15	1/27/2015	NON-COMPETING CONTINUATION	$497,810
														Subtotal = $497,810

Issue Date FY: 2014 ( Subtotal = $473,798 )
2014	2014	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	14	2/3/2014	NON-COMPETING CONTINUATION	$439,607
2014	2014	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	14	4/10/2014	NON-COMPETING CONTINUATION	$34,191
														Subtotal = $473,798

Issue Date FY: 2013 ( Subtotal = $545,535 )
2013	2013	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	13	6/11/2013	NON-COMPETING CONTINUATION	$14,422
2013	2013	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	13	1/21/2013	NON-COMPETING CONTINUATION	$432,647
2013	2013	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	002	13	9/20/2013	SUPPLEMENT FOR EXPANSION	$98,466
														Subtotal = $545,535

Issue Date FY: 2012 ( Subtotal = $472,967 )
2012	2012	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	12	2/14/2012	COMPETING CONTINUATION	$472,967
														Subtotal = $472,967

Issue Date FY: 2011 ( Subtotal = $516,444 )
2011	2011	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	11	1/24/2011	NON-COMPETING CONTINUATION	$483,579
2011	2011	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	11	7/5/2011	NON-COMPETING CONTINUATION	$32,865
														Subtotal = $516,444

Issue Date FY: 2010 ( Subtotal = $581,084 )
2010	2010	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	10	1/29/2010	NON-COMPETING CONTINUATION	$581,084
														Subtotal = $581,084

Issue Date FY: 2009 ( Subtotal = $576,826 )
2009	2009	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	9	1/22/2009	NON-COMPETING CONTINUATION	$519,144
2009	2009	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	9	6/23/2009	NON-COMPETING CONTINUATION	$57,682
														Subtotal = $576,826

Issue Date FY: 2008 ( Subtotal = $644,674 ) (Continued on the next page)
Grand Total All Awards = $10,924,393

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6/8: INIA Stress and Chronic Alcohol Interactions: Stress and Ethanol Self Administration in Monkeys

Award Number: U01AA013510

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2002

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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