Tuesday, July 1, 2025 7/1/2025

Dartmouth Cystic Fibrosis Training Program

Award Number: T32HL134598
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 03/01/2017
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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Dartmouth Cystic Fibrosis Training Program - In this application, we propose continued funding to the Dartmouth Cystic Fibrosis Training Program (DCFTP). Continuing support is sought for a comprehensive, highly interactive, interdepartmental training program with an emphasis on CF basic and translational science. The overall philosophy of the program is to use a disease-centered approach to teach fundamental concepts of basic and translational science in the context of a dynamic, multidisciplinary research and team-based mentoring environment. In this submission, we propose to directly fund 4 Trainees annually. Our program has pooled the talents of 22 dedicated Faculty Trainers from a wide range of departments—our current program includes faculty in the departments of Biochemistry and Cell Biology, Chemistry, Molecular Systems Biology, Medicine, Microbiology/ Immunology, Epidemiology, Pediatrics, and Engineering—to provide instruction in CF-related research to PhD and MD/PhD students. The DCFTP will function in the context of a Research Base already rich in basic, translational, and clinical CF-related studies. The CF research program at Dartmouth has grown from three investigators and one NIH grant in 1997 to a community of world-class scientists that currently secure $21.1M per year in direct costs of research funding ($0.96M per investigator average). Dartmouth will also provide ~$39.6M in institutional support, including direct support to DartCF, our training program and the affiliated graduate programs, over the next 5 years. Our Training Faculty use approaches including the study of clinical cohorts, quantitative methods, and laboratory-based and animal studies; thus, our trainees are exposed to a broad range of scientific strategies to answer impactful scientific questions. The DCFTP participating Training Faculty, which include PhD, MD, and MD/PhD researchers, work in a range of disciplines, with CF research as the central focus; all Training Faculty conduct research, are well funded, and teach and mentor our Trainees. This group of basic and physician-scientist researchers is actively engaged in CF-related research, with expertise in cell biology, structural biology, microbiology, immunology, microbiome, genetics, bioinformatics, statistics, and proteomics. A hallmark of our program is the close and consistent interaction of our Training Faculty with our DCFTP Trainees via DCFTP-sponsored general and Trainee-specific activities, including weekly research meetings, courses, journal clubs, and our annual retreat. Training-grant funds and DCFTP- sponsored, Trainee-specific enhanced activities provide a unifying base that greatly facilitates the strikingly interactive nature of this group (evidenced by 38 collaborative publications over the past ~5 years among our 22 Training and 9 Affiliated Faculty) and of the collaborative grants held by these faculty.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $214,496 )
2025	2025	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	001	8	4/22/2025	NON-COMPETING CONTINUATION	$214,496
2025	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	000	7	12/4/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $214,496

Issue Date FY: 2024 ( Subtotal = $224,496 )
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	002	7	8/23/2024	NON-COMPETING CONTINUATION	$7,530
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	001	7	1/29/2024	NON-COMPETING CONTINUATION	$216,966
2024	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	000	6	11/8/2023	COMPETING CONTINUATION	$0
														Subtotal = $224,496

Issue Date FY: 2023 ( Subtotal = $216,966 )
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	003	6	5/16/2023	COMPETING CONTINUATION	$0
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	002	6	3/14/2023	COMPETING CONTINUATION	$4,069
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	001	6	1/31/2023	COMPETING CONTINUATION	$212,897
2023	2021	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	000	5	1/4/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $216,966

Issue Date FY: 2022 ( Subtotal = -$1,371 )
2022	2021	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	000	5	8/12/2022	NON-COMPETING CONTINUATION	-$1,371
														Subtotal = -$1,371

Issue Date FY: 2021 ( Subtotal = $198,927 )
2021	2021	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	000	5	4/16/2021	NON-COMPETING CONTINUATION	$198,927
														Subtotal = $198,927

Issue Date FY: 2020 ( Subtotal = $197,574 )
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	000	4	3/6/2020	NON-COMPETING CONTINUATION	$197,574
														Subtotal = $197,574

Issue Date FY: 2019 ( Subtotal = $195,397 )
2019	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	000	3	3/1/2019	NON-COMPETING CONTINUATION	$195,397
														Subtotal = $195,397

Issue Date FY: 2018 ( Subtotal = $193,272 )
2018	2018	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	001	2	8/13/2018	NON-COMPETING CONTINUATION	$2,074
2018	2018	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	000	2	2/17/2018	NON-COMPETING CONTINUATION	$191,198
														Subtotal = $193,272

Issue Date FY: 2017 ( Subtotal = $95,599 )
2017	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	000	1	2/26/2017	NEW	$94,588
2017	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Lung Diseases Research	001	1	7/14/2017	NEW	$1,011
														Subtotal = $95,599

Grand Total All Awards = $1,535,356

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Dartmouth Cystic Fibrosis Training Program

Award Number: T32HL134598

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 03/01/2017

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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