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Training Grant in Circadian and Sleep Research

Award Number: T32HL007909
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/1998
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Training Grant in Circadian and Sleep Research - Project Summary/Abstract This is a renewal application of an established NHLBI- sponsored T32, “Training Grant in Circadian and Sleep Research”, to train predoctoral and postdoctoral students and fellows at Northwestern University. The integration of circadian biology and sleep research has been the cornerstone of this Training Program from its inception in 1998. Dr. Fred Turek will be one of the Program Directors of this T32 Program, which he has been for 20 years. Dr. Phyllis Zee will also be one of the two Program Directors (Multiple PI), in order to provide leadership for increasing clinical research training in Circadian Biology and Sleep Research for Fellows and residents at the Northwestern University Feinberg School of Medicine (FSM) who will become leading physician scientists as their careers develop. The T32 Program will involve 15 Primary Training Faculty who have their primary appointments in either basic science or clinical departments. The proposed Training Program will offer predoctoral and postdoctoral students interdisciplinary and multidisciplinary training in a wide range of scientific disciplines that are highly relevant to understanding the function, regulation and health implications of sleep and circadian rhythmicity. Central to this Program is the training of students in modern basic science, translational research as well as patient oriented research. Multiple research perspectives have fueled for more than 2 decades the productive interactions and cross-fertilization that have developed between the preceptors in this Program. As our nation is facing unprecedented epidemics of obesity, diabetes and their cardiovascular consequences, the Training Program proposed in the present application is uniquely positioned to train an interdisciplinary workforce of academic and industry investigators, as well as government decision makers, to address the roles of sleep disturbances and circadian dysfunction in these public health challenges. A key feature of our Training Program is the inclusion of 7 Collaborating Faculty with additional clinical, scientific and/or educational expertise that greatly enhances our training environment. Our Program will enable trainees to integrate cutting edge approaches and techniques in the areas of genetics, genomics, microbiomics, endocrinology, metabolism, pharmacology, neurobiology, pulmonology, cognitive neuroscience, gerontology, and gastroenterology into their training in sleep and circadian research. Because the preceptors are actively involved in research at the molecular, cellular, systems, behavioral, and epidemiological levels, trainees will be trained in a rich environment of research activities that are integrated to study of the basic mechanisms of sleep and circadian function at all levels of biological organization. We are requesting support from this T32 renewal for 4 predoctoral students and 4 postdoctoral fellows for each of the five years. We anticipate the training period will be 2-3 years for each student/fellow, although it may be less if a trainee obtains individual support through other funding sources. It should be noted that the NU graduate school will provide support for an additional 2 predoctoral students for each of the next 5 years of this Training Program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $420,281 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	000	25	3/2/2024	NON-COMPETING CONTINUATION	$390,162
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	001	25	8/22/2024	NON-COMPETING CONTINUATION	$30,119
														Subtotal = $420,281

Issue Date FY: 2023 ( Subtotal = $532,347 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	001	24	5/31/2023	NON-COMPETING CONTINUATION	$0
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	000	24	2/28/2023	NON-COMPETING CONTINUATION	$532,347
														Subtotal = $532,347

Issue Date FY: 2022 ( Subtotal = $520,044 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	001	23	7/6/2022	NON-COMPETING CONTINUATION	$8,230
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	000	23	2/25/2022	NON-COMPETING CONTINUATION	$511,814
														Subtotal = $520,044

Issue Date FY: 2021 ( Subtotal = $490,946 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	002	22	5/5/2021	NON-COMPETING CONTINUATION	$490,946
2021	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	001	21	2/17/2021	COMPETING CONTINUATION	$75,861
2021	2018	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	000	20	2/17/2021	NON-COMPETING CONTINUATION	-$75,861
														Subtotal = $490,946

Issue Date FY: 2020 ( Subtotal = $484,945 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	001	21	2/27/2020	COMPETING CONTINUATION	$484,945
2020	2018	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	000	20	2/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $484,945

Issue Date FY: 2018 ( Subtotal = $236,242 )
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	000	20	4/4/2018	NON-COMPETING CONTINUATION	$225,416
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	001	20	8/9/2018	NON-COMPETING CONTINUATION	$10,826
														Subtotal = $236,242

Issue Date FY: 2017 ( Subtotal = $456,334 )
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	001	19	5/10/2017	NON-COMPETING CONTINUATION	$450,756
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	000	18	2/6/2017	SUPPLEMENT FOR EXPANSION	$3,020
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	National Center on Sleep Disorders Research	002	19	7/21/2017	NON-COMPETING CONTINUATION	$2,558
														Subtotal = $456,334

Issue Date FY: 2016 ( Subtotal = $446,756 )
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cardiovascular Diseases Research	000	18	3/31/2016	NON-COMPETING CONTINUATION	$446,756
														Subtotal = $446,756

Issue Date FY: 2015 ( Subtotal = $436,216 )
2015	2015	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cardiovascular Diseases Research	000	17	2/26/2015	NON-COMPETING CONTINUATION	$436,216
														Subtotal = $436,216

Issue Date FY: 2014 ( Subtotal = $430,124 )
2014	2014	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cardiovascular Diseases Research	001	16	4/25/2014	COMPETING CONTINUATION	$430,124
2014	2012	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60201	COOK	USA	Cardiovascular Diseases Research	000	15	4/23/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $430,124

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2012	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cardiovascular Diseases Research	000	15	5/23/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $404,212 )
2012	2012	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cardiovascular Diseases Research	000	14	5/7/2012	SUPPLEMENT FOR EXPANSION	$50,054
2012	2012	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cardiovascular Diseases Research	001	15	8/1/2012	NON-COMPETING CONTINUATION	$354,158
														Subtotal = $404,212

Issue Date FY: 2011 ( Subtotal = $320,238 )
2011	2011	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cardiovascular Diseases Research	000	14	7/26/2011	NON-COMPETING CONTINUATION	$320,238
														Subtotal = $320,238

Issue Date FY: 2010 ( Subtotal = $315,831 )
2010	2010	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cardiovascular Diseases Research	000	13	8/18/2010	NON-COMPETING CONTINUATION	$315,831
														Subtotal = $315,831

Issue Date FY: 2009 ( Subtotal = $348,667 )
2009	2009	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cardiovascular Diseases Research	000	10	8/6/2009	SUPPLEMENT FOR EXPANSION	$35,000
2009	2009	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60201	COOK	USA	Cardiovascular Diseases Research	001	10	8/20/2009	SUPPLEMENT FOR EXPANSION	$0
2009	2009	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cardiovascular Diseases Research	002	12	8/19/2009	NON-COMPETING CONTINUATION	$313,667
														Subtotal = $348,667

Issue Date FY: 2008 ( Subtotal = $311,528 )
2008	2008	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60201	COOK	USA	Cardiovascular Diseases Research	000	11	9/1/2008	COMPETING CONTINUATION	$311,528
														Subtotal = $311,528

Issue Date FY: 2007 ( Subtotal = $210,634 )
2007	2007	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60201	COOK	USA	National Center on Sleep Disorders Research	000	10	7/1/2007	NON-COMPETING CONTINUATION	$210,634
														Subtotal = $210,634

Issue Date FY: 2006 ( Subtotal = $280,363 )
2006	2006	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60201	COOK	USA	National Center on Sleep Disorders Research	000	9	7/14/2006	NON-COMPETING CONTINUATION	$280,363
														Subtotal = $280,363

Issue Date FY: 2004 ( Subtotal = $277,123 ) (Continued on the next page)
Grand Total All Awards = $8,285,443

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Training Grant in Circadian and Sleep Research

Award Number: T32HL007909

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/1998

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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