Monday, June 23, 2025 6/23/2025

Genetics and Genomics of Human Disease

Award Number: T32HD007149
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/1978
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Genetics and Genomics of Human Disease - Project Summary/Abstract Continuing support is requested for years 46-50 of the Yale Predoctoral Training Program in Human Genetics and Genomics. The program constitutes 52 trainers, the majority of whom are primary or secondary appointees in the Department of Genetics at the School of Medicine. Virtually all of the trainees over the last funding period have been matriculated in the Molecular Cell Biology, Genetics & Development Track (MCGD) in Biological and Biomedical Sciences at Yale. The proposed training program is focused on the use of genetic, genomic and computational approaches to understand human biology and disease. Training encompasses three core domains: 1) The genetics of human health and disease, encompassing disease gene discovery and the interpretation of human genetic variation; 2) Experimental studies in model organisms to understand how human genetic variation influences human biology and disease; and 3) Genomic technologies and computational approaches to obtain biological insights from complex genomic datasets, both in human and model systems. Training faculty include investigators who are world leaders in each of these domains. This integrated training environment provides trainees with broad exposure to genetics, genomics and computational biology, and a rich training environment that prepares them for careers in science. Students admitted into the program have strong scientific backgrounds and research experience with high academic achievement. First year students are supported by Yale. Students are then supported by the training grant in years 2 and 3, and thereafter by funds in Training Faculty laboratories until graduation. Training in the first year includes formal course work focused on genetics, genomics and data analysis, as well as research rotations leading to selection of the thesis advisor and laboratory. In the second year, students complete course work and take a qualifying exam in which they must demonstrate mastery of genetics and defend a written research proposal. Subsequent years are devoted to dissertation research, development of experimental and analytic skills, and skills in written and oral presentation, leading to preparation and publication of the thesis work. In addition, students engage in supervised teaching experiences. The students also participate in Departmental and new Program-specific activities, including a Program Symposium and a Career Development Workshop. These activities provide students with targeted mentoring and career development opportunities and will help them develop a professional network of peers and senior colleagues that they can draw upon throughout their careers. Support is requested for 5 years for 7 Ph.D. students per year. Trainees are highly successful in completing their Ph.D. thesis work, publishing their work in high-impact journals, and the vast majority continue to contribute to science after leaving the program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $475,655 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	003	47	5/7/2025	NON-COMPETING CONTINUATION	$371,063
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	46	2/13/2025	COMPETING CONTINUATION	$104,592
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	002	46	2/24/2025	COMPETING CONTINUATION	$92,958
2025	2023	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	001	45	2/24/2025	NON-COMPETING CONTINUATION	-$92,958
														Subtotal = $475,655

Issue Date FY: 2024 ( Subtotal = $265,210 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	001	46	6/13/2024	COMPETING CONTINUATION	$265,210
2024	2023	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	45	6/7/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $265,210

Issue Date FY: 2023 ( Subtotal = $368,833 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	45	4/26/2023	NON-COMPETING CONTINUATION	$368,833
														Subtotal = $368,833

Issue Date FY: 2022 ( Subtotal = $360,507 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	44	4/28/2022	NON-COMPETING CONTINUATION	$360,507
														Subtotal = $360,507

Issue Date FY: 2021 ( Subtotal = $338,201 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	43	5/21/2021	NON-COMPETING CONTINUATION	$338,201
														Subtotal = $338,201

Issue Date FY: 2020 ( Subtotal = $338,951 )
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	42	6/10/2020	NON-COMPETING CONTINUATION	$338,951
														Subtotal = $338,951

Issue Date FY: 2019 ( Subtotal = $335,140 )
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	001	41	8/19/2019	COMPETING CONTINUATION	$335,141
2019	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	40	1/17/2019	NON-COMPETING CONTINUATION	-$1
														Subtotal = $335,140

Issue Date FY: 2017 ( Subtotal = $325,827 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	40	8/15/2017	NON-COMPETING CONTINUATION	$325,827
														Subtotal = $325,827

Issue Date FY: 2016 ( Subtotal = $286,083 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	39	5/4/2016	EXTENSION WITH OR WITHOUT FUNDS	$286,083
														Subtotal = $286,083

Issue Date FY: 2015 ( Subtotal = $319,828 )
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	38	5/14/2015	NON-COMPETING CONTINUATION	$319,828
														Subtotal = $319,828

Issue Date FY: 2014 ( Subtotal = $317,451 )
2014	2014	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	37	7/11/2014	NON-COMPETING CONTINUATION	$317,451
														Subtotal = $317,451

Issue Date FY: 2013 ( Subtotal = $314,094 )
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	001	36	7/29/2013	COMPETING CONTINUATION	$314,094
2013	2013	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	003	36	7/31/2013	COMPETING CONTINUATION	$0
2013	2012	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	002	35	7/30/2013	NON-COMPETING CONTINUATION	$0
2013	2012	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	35	7/24/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $314,094

Issue Date FY: 2012 ( Subtotal = $314,094 )
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	35	5/2/2012	NON-COMPETING CONTINUATION	$314,094
														Subtotal = $314,094

Issue Date FY: 2011 ( Subtotal = $308,512 )
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	34	6/7/2011	NON-COMPETING CONTINUATION	$308,512
														Subtotal = $308,512

Issue Date FY: 2010 ( Subtotal = $301,807 )
2010	2010	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	33	7/6/2010	NON-COMPETING CONTINUATION	$301,807
														Subtotal = $301,807

Issue Date FY: 2009 ( Subtotal = $298,582 )
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	32	5/7/2009	NON-COMPETING CONTINUATION	$298,582
														Subtotal = $298,582

Issue Date FY: 2008 ( Subtotal = $303,483 )
2008	2008	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	31	5/5/2008	COMPETING CONTINUATION	$303,483
														Subtotal = $303,483

Issue Date FY: 2007 ( Subtotal = $294,708 )
2007	2007	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	30	5/2/2007	NON-COMPETING CONTINUATION	$294,708
														Subtotal = $294,708

Issue Date FY: 2006 ( Subtotal = $289,132 )
2006	2006	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	29	5/11/2006	NON-COMPETING CONTINUATION	$289,132
														Subtotal = $289,132

Issue Date FY: 2004 ( Subtotal = $424,470 )
2004	2004	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	27	5/5/2004	NON-COMPETING CONTINUATION	$424,470
														Subtotal = $424,470

Issue Date FY: 2003 ( Subtotal = $416,444 )
2003	2003	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	26		COMPETING CONTINUATION	$416,444
														Subtotal = $416,444

Grand Total All Awards = $8,013,872

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Genetics and Genomics of Human Disease

Award Number: T32HD007149

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/1978

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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