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Training Program in Translational Vision Sciences

Award Number: T32EY025187
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2016
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Training Program in Translational Vision Sciences - Project Summary/Abstract Translating basic vision research to the clinic progresses at an astounding rate, but we still have a long way to go in developing treatments and potential cures for blinding vision diseases. The advancements in methods, e.g., viral vectors, genetic approaches, single cell transcriptomics, imaging modalities, optogenetics, and stem cell-based approaches, have changed our ability to understand the visual system in health and disease. The major aim of the University of Minnesota’s program in the Training in Translational Vision Sciences is to prepare predoctoral trainees for careers as independent scientists with excellent knowledge of basic science, and importantly, provide connections to clinical problems and real patients with vision-threatening disorders. The 18 training faculty are a well-funded, productive group of vision scientists with a commitment to training the next generation of vision scientists. Ten of these 18 have funding from the National Eye Institute, but all preceptors have well-funded laboratories and strong publication records. The major areas of research focus include real- time imaging, visual processing in human and animal models, vascular biology, and development. These focus areas are typically coupled with a strong translational objective focused on developing new strategies to improve vision in individuals with significant visual impairment. We are requesting funding to support five predoctoral candidates who have entered into the laboratories of one of the vision scientist preceptors. Predoctoral trainees will come from one of four graduate programs: “Neuroscience”, “Molecular, Cellular, Developmental Biology & Genetics”, or “Biochemistry, Molecular Biology, and Biophysics” in the medical school, or the Graduate Program in Psychology in the College of Liberal Arts. With the focus on translational vision science, we have greatly increased the collaborations between basic scientists and the clinical faculty in the Department of Ophthalmology and Visual Neurosciences (DOVN). Several new key elements of the Translational Vision Research Training program include a newly designed course for trainees, Critical and Translational Reasoning in Visual Science, co-taught by the training faculty and the clinical faculty in the DOVN. All trainees must attend and present their research at our annual Spring Symposium, where nationally known and in-house experts in vision science present their most recent research along with our trainees and faculty as well as participate in one of several vision-related journal clubs. The Program Directors and Executive Committee select and evaluate trainees for this program. The program directors are Linda McLoon PhD and Harald Junge PhD, both in the DOVN. We have built in a Program Director transition plan, with Drs. McLoon and Junge sharing the position during the first two years of the program, and with Dr. Junge taking over as Principal Investigator in years three to five. As we move toward increasingly collaborative research between our basic and clinically trained faculty members, the training we provide will maximize our ability to prepare vision scientists with a multi-disciplinary education needed to meet the “audacious goals” of the NEI - focused on preventing, treating, and rehabilitating blinding eye disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $118,053 )
2026	2026	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Vision Research	000	10	3/26/2026	NON-COMPETING CONTINUATION	$118,053
														Subtotal = $118,053

Issue Date FY: 2025 ( Subtotal = $119,210 )
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Vision Research	000	9	7/10/2025	NON-COMPETING CONTINUATION	$119,210
														Subtotal = $119,210

Issue Date FY: 2024 ( Subtotal = $129,797 )
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	000	8	5/2/2024	NON-COMPETING CONTINUATION	$129,797
														Subtotal = $129,797

Issue Date FY: 2023 ( Subtotal = $155,651 )
2023	2023	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	002	7	2/27/2023	NON-COMPETING CONTINUATION	$155,651
2023	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	001	6	11/16/2022	COMPETING CONTINUATION	$17,163
2023	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	000	5	11/16/2022	NON-COMPETING CONTINUATION	-$17,163
														Subtotal = $155,651

Issue Date FY: 2022 ( Subtotal = $147,620 )
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	002	6	4/13/2022	COMPETING CONTINUATION	$145,301
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	003	6	5/23/2022	COMPETING CONTINUATION	$2,319
2022	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	001	5	4/7/2022	NON-COMPETING CONTINUATION	$0
2022	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	000	5	1/6/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $147,620

Issue Date FY: 2020 ( Subtotal = $45,237 )
2020	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	000	5	8/28/2020	NON-COMPETING CONTINUATION	$45,237
														Subtotal = $45,237

Issue Date FY: 2019 ( Subtotal = $89,289 )
2019	2019	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	000	4	8/29/2019	NON-COMPETING CONTINUATION	$89,289
														Subtotal = $89,289

Issue Date FY: 2018 ( Subtotal = $118,070 )
2018	2018	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	000	3	8/10/2018	NON-COMPETING CONTINUATION	$118,070
														Subtotal = $118,070

Issue Date FY: 2017 ( Subtotal = $142,103 )
2017	2017	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	000	2	9/7/2017	NON-COMPETING CONTINUATION	$142,103
														Subtotal = $142,103

Issue Date FY: 2016 ( Subtotal = $140,586 )
2016	2016	UNIVERSITY OF MINNESOTA, OFFICE OF STUDENT FINANCE AID	106 PLEASANT SE, 210 FRASER HL	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Vision Research	000	1	8/8/2016	NEW	$140,586
														Subtotal = $140,586

Grand Total All Awards = $1,205,616

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Training Program in Translational Vision Sciences

Award Number: T32EY025187

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2016

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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