Sunday, November 24, 2024 11/24/2024

Biological Bases of Drug-Seeking Behavior

Award Number: T32DA007262
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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Project Summary / Abstract This program for pre- and post-doctoral training supports the training of specialists who are able to conduct preclinical research at levels ranging from the molecular to the cognitive/clinical on the biological mechanisms underlying the development, maintenance, and elimination of drug-seeking behavior. Twenty-three members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for postdoctoral research fellows and for Ph.D. students matriculating into basic science graduate programs in behavioral neuroscience, neuroscience, physiology and pharmacology, or biochemistry. Major research areas represent four levels. Some faculty members work primarily at the cellular/molecular level, using molecular biological, cell biological, and electron microscopic techniques. Other faculty work principally at the level of physiological, biochemical and pharmacological systems, using receptor binding, autoradiography, in vivo microdialysis and voltammetry, and electrophysiological techniques, and some work primarily in behavioral pharmacology and pharmacogenetics, using behavioral testing, intravenous drug self-administration, quantitative genetics and genetic mapping, as well as computer modelling techniques. Finally, some faculty work with human subjects, using cognitive testing and a variety of imaging techniques. Areas of extensive existing faculty collaboration include: studies of dopaminergic systems, ranging from molecular biology to behavior; extensive studies of genetic determinants of drug responses, at all levels from molecular to statistical gene mapping; and the study of learned and unlearned determinants of responses to drugs, particularly their rewarding effects and drug self- administration. Sensitivity, tolerance, and dependence/withdrawal phenomena for all major classes of drugs of abuse are under active investigation. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in abused drugs, and extensive and continuous participation in research. Trainees also receive extensive instruction in the responsible conduct of research through interactive seminars that cover ethical considerations in all aspects of science. OHSU and this training program have put considerable efforts into recruiting and retaining trainees from diverse backgrounds. These efforts have resulted in a significantly more diverse pool of graduate students and postdoctoral fellows receiving training in the biological basis of drug-seeking behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$129,646 )
2025	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Use and Addiction Research Programs	000	30	11/13/2024	NON-COMPETING CONTINUATION	-$129,646
														Subtotal = -$129,646

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Use and Addiction Research Programs	000	30	2/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $568,084 )
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Use and Addiction Research Programs	000	30	4/22/2022	NON-COMPETING CONTINUATION	$568,080
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Use and Addiction Research Programs	001	30	5/24/2022	NON-COMPETING CONTINUATION	$4
														Subtotal = $568,084

Issue Date FY: 2021 ( Subtotal = $536,607 )
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	002	29	5/3/2021	NON-COMPETING CONTINUATION	$536,607
2021	2015	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	25	10/1/2020	NON-COMPETING CONTINUATION	$0
2021	2015	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	001	25	10/3/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $536,607

Issue Date FY: 2020 ( Subtotal = $529,220 )
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	28	5/14/2020	NON-COMPETING CONTINUATION	$529,220
														Subtotal = $529,220

Issue Date FY: 2019 ( Subtotal = $510,514 )
2019	2019	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	27	4/19/2019	NON-COMPETING CONTINUATION	$510,514
														Subtotal = $510,514

Issue Date FY: 2018 ( Subtotal = $489,322 )
2018	2018	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	001	26	5/22/2018	COMPETING CONTINUATION	$496,746
2018	2015	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	25	3/16/2018	NON-COMPETING CONTINUATION	-$7,424
														Subtotal = $489,322

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	25	7/7/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $507,156 )
2015	2015	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	25	6/10/2015	NON-COMPETING CONTINUATION	$507,156
														Subtotal = $507,156

Issue Date FY: 2014 ( Subtotal = $404,791 )
2014	2014	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	24	6/25/2014	NON-COMPETING CONTINUATION	$404,791
														Subtotal = $404,791

Issue Date FY: 2013 ( Subtotal = $488,066 )
2013	2013	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	23	6/28/2013	NON-COMPETING CONTINUATION	$488,066
														Subtotal = $488,066

Issue Date FY: 2012 ( Subtotal = $488,066 )
2012	2012	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	22	7/5/2012	NON-COMPETING CONTINUATION	$488,066
														Subtotal = $488,066

Issue Date FY: 2011 ( Subtotal = $481,793 )
2011	2011	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	21	6/30/2011	COMPETING CONTINUATION	$481,793
														Subtotal = $481,793

Issue Date FY: 2010 ( Subtotal = $473,076 )
2010	2010	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	20	6/17/2010	NON-COMPETING CONTINUATION	$473,076
														Subtotal = $473,076

Issue Date FY: 2009 ( Subtotal = $470,069 )
2009	2009	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	19	6/24/2009	NON-COMPETING CONTINUATION	$470,069
														Subtotal = $470,069

Issue Date FY: 2008 ( Subtotal = $467,089 )
2008	2008	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97201	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	18	8/1/2008	NON-COMPETING CONTINUATION	$467,089
														Subtotal = $467,089

Issue Date FY: 2007 ( Subtotal = $467,089 )
2007	2007	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97201	MULTNOMAH	USA	Drug Abuse and Addiction Research Programs	000	17	7/19/2007	NON-COMPETING CONTINUATION	$467,089
														Subtotal = $467,089

Issue Date FY: 2006 ( Subtotal = $469,230 )
2006	2006	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97201	MULTNOMAH	USA	Drug Abuse National Research Service Awards for Research Training	000	16	6/30/2006	COMPETING CONTINUATION	$469,230
														Subtotal = $469,230

Issue Date FY: 2004 ( Subtotal = $387,259 )
2004	2004	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97201	MULTNOMAH	USA	Drug Abuse National Research Service Awards for Research Training	000	14	7/22/2004	NON-COMPETING CONTINUATION	$387,259
														Subtotal = $387,259

Issue Date FY: 2003 ( Subtotal = $331,838 )
2003	2003	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97201	MULTNOMAH	USA	Drug Abuse National Research Service Awards for Research Training	000	13	6/24/2003	NON-COMPETING CONTINUATION	$331,838
														Subtotal = $331,838

Issue Date FY: 2002 ( Subtotal = $248,923 )
2002	2002	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97201	MULTNOMAH	USA	Drug Abuse National Research Service Awards for Research Training	000	12	8/12/2002	NON-COMPETING CONTINUATION	$248,923
														Subtotal = $248,923

Issue Date FY: 2001 ( Subtotal = $351,196 )
2001	2001	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97201	MULTNOMAH	USA	Drug Abuse National Research Service Awards for Research Training	000	11	5/25/2001	COMPETING CONTINUATION	$351,196
														Subtotal = $351,196

Issue Date FY: 2000 ( Subtotal = $343,403 )
2000	2000	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97201	MULTNOMAH	USA	Drug Abuse National Research Service Awards for Research Training	000	10	6/20/2000	NON-COMPETING CONTINUATION	$343,403
														Subtotal = $343,403

Grand Total All Awards = $9,467,401

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Biological Bases of Drug-Seeking Behavior

Award Number: T32DA007262

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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