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Translational Oncology Training Program

Award Number: T32CA247819
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Translational Oncology Training Program - Summary Cancer is the second leading cause of death in the US, and many challenges still remain to discover novel and more effective approaches to cure this devastating disease, which requires strong effort in translating basic science knowledge into clinics. To accomplish this goal and further promote translational cancer research, it is imperative to establish a sustainable program to train and educate the next generation of scientists and clinicians, who must have broad knowledge and the ability to communicate and work with colleagues in both fields. The goal of the Translational Oncology Training program (TOTP) is to ensure that the next generation of cancer researchers are equipped with the tools and knowledge that will enable them to bring bench-top discoveries into clinical trials and vice versa. The fellows and students in this program will receive unique training in four different but highly integrated themes: Preclinical Modeling (PCM); Cancer Image Guidance (CIG); Cancer Bio-Validation (CBV); and Clinical Translation (CLT). PCM focuses on analysis of pathways and signaling involved in tumor progression using various preclinical models in order to identify potential therapeutic targets and biomarkers. CIG provides training in state of the art image-guided diagnostic approaches and nanotechnology-based drug delivery systems. Trainees in CBV will learn up-to-date bioinformatics skills in multi-omics setting in order to study and analyze large cohort patient database. Preceptors in CLT have ample experiences in clinical trials and they provide guidance on how to translate basic knowledge into clinical trials. Trainees will rotate through three out of four themes during the first year while taking didactic lectures from all four themes. They will also assemble a mentoring team consisting of both Ph.D and MD faculty. The majority of preceptors of this T32 program are in the Hematology/Oncology and Cancer Biology departments. This structure merges strong clinical and basic science entities in the Wake Forest Baptist Comprehensive Cancer Center (WFBCCC). However, this training program is multidisciplinary and in all, preceptors come from 11 different departments. The program is unique with many innovative training tools: (i) highly integrated 4 translational themes that include both didactic lectures and hands-on rotations among the themes; (ii) inclusion of both Ph.D postdocs and MD fellows to promote both bench-to-bedside and bedside-to-benchtop translational cancer research; (iii) an individualized mentor team consisting of both Ph.D and MD faculty; (iv) boot camp for clinical trial preparation for trainees (v) support from Disease Oriented Teams (DOTs) from WFBCCC; (vi) Transition to Independence (TTI) program to support trainees to become independent through preparation for K-type applications; and (vii) Broad-base career opportunities and development plans such as Ph.D/MBA for graduate students. Therefore, through this training program, Ph.D fellows/students will learn how they can bring basic science knowledge into bedside, while MD fellows will have a deeper understanding of translational, hypothesis-driven research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $266,711 )
2024	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cancer Research Manpower	000	5	4/1/2024	NON-COMPETING CONTINUATION	$245,508
2024	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cancer Research Manpower	001	5	5/7/2024	NON-COMPETING CONTINUATION	$21,203
														Subtotal = $266,711

Issue Date FY: 2023 ( Subtotal = $320,060 )
2023	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cancer Research Manpower	000	4	3/2/2023	NON-COMPETING CONTINUATION	$320,060
														Subtotal = $320,060

Issue Date FY: 2022 ( Subtotal = $279,234 )
2022	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cancer Research Manpower	001	3	5/10/2022	NON-COMPETING CONTINUATION	$5,046
2022	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cancer Research Manpower	002	3	6/23/2022	NON-COMPETING CONTINUATION	$4
2022	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cancer Research Manpower	000	3	4/1/2022	NON-COMPETING CONTINUATION	$274,184
														Subtotal = $279,234

Issue Date FY: 2021 ( Subtotal = $276,006 )
2021	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cancer Research Manpower	000	2	3/18/2021	NON-COMPETING CONTINUATION	$276,006
														Subtotal = $276,006

Issue Date FY: 2020 ( Subtotal = $267,102 )
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cancer Research Manpower	000	1	2/27/2020	NEW	$267,102
														Subtotal = $267,102

Grand Total All Awards = $1,409,113

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Translational Oncology Training Program

Award Number: T32CA247819

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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