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VIRUS-HOST INTERACTIONS IN CANCER

Award Number: T32CA009031
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/1986
PERIOD OF PERFORMANCE END DATE: 05/31/2010

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VIRUS-HOST INTERACTIONS IN CANCER - DESCRIPTION (provided by applicant): Viruses are a significant cause of human cancer and are an even more common cause of cancer in immune deficient humans such as organ transplant recipients or HIV infected people. Analyses of the way viruses alter cell growth has also frequently led to the delineation of novel pathways of cell growth, cell survival and oncogenicity. This Viral Oncology Training Program will provide support for 2 graduate students for G2 or G3 years and for 5 post-doctoral trainees each year for the laboratories of 16 Viral Oncology Program faculty members at Harvard University and its closely affiliated institutions. The research objectives of these laboratories include: (1) Molecular pathogenesis of Human Papillomavirus induced malignancies including cervical, anogenital and oral cancer. (2) Molecular pathogenesis human and primate gamma herpes virus induced malignancies including lymphoproliferative disease and nasopharyngeal carcinoma. (3) Molecular mechanisms by which small DMA tumor viruses including Papovaviruses and Adenoviruses alter cell growth and survival. (4) Molecular mechanisms by which RNA tumor viruses infect and alter cell signal transduction, transcription, cell cycle regulation, and cell survival, and (5) Translational research in areas 1 and 2 including therapeutic target identification, target validation, small molecule screens, and experimental models, as well as programmatic objectives that emerge through interactions with disease and population based investigators. Graduate students engage in viral oncology laboratory research training while pursue 3 semesters of course work in molecular biology, genetics, cell biology, virology and immunology. The course work is based in reading of research papers and proposal writing. By January of year 2, students are in full time mentored thesis research. Post-doctoral fellows engage full time in mentored research training. Pre- and post-doctoral students also participate in seminars, journal clubs, and research conferences including conferences of the Virology Program and of the DF/HCC Viral Oncology Program. Trainees are jointly mentored by research trainer and by other program faculty. On completion of their thesis research pre-doctoral students are prepared for postdoctoral research in viral oncology and related disciplines. Postdoctoral trainees are prepared for independent research in viral oncology and related disciplines. This application has been revised to comply with suggestions made in the previous review.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $301,898 )
2009	2009	HARVARD UNIVERSITY MEDICAL SCHOOL	643 HUNTINGTON AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Research Manpower	000	33	5/5/2009	NON-COMPETING CONTINUATION	$301,898
														Subtotal = $301,898

Issue Date FY: 2008 ( Subtotal = $306,523 )
2008	2008	HARVARD UNIVERSITY MEDICAL SCHOOL	643 HUNTINGTON AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Research Manpower	000	32	5/16/2008	NON-COMPETING CONTINUATION	$306,523
														Subtotal = $306,523

Issue Date FY: 2007 ( Subtotal = $238,805 )
2007	2007	HARVARD UNIVERSITY MEDICAL SCHOOL	643 HUNTINGTON AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Research Manpower	000	31	7/24/2007	NON-COMPETING CONTINUATION	$238,805
														Subtotal = $238,805

Issue Date FY: 2006 ( Subtotal = $260,417 )
2006	2006	HARVARD UNIVERSITY MEDICAL SCHOOL	643 HUNTINGTON AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Research Manpower	000	30	5/24/2006	NON-COMPETING CONTINUATION	$260,417
														Subtotal = $260,417

Issue Date FY: 2003 ( Subtotal = $291,902 )
2003	2003	HARVARD UNIVERSITY, SCHOOL OF MEDICINE	25 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Research Manpower	000	28	5/30/2003	NON-COMPETING CONTINUATION	$291,902
														Subtotal = $291,902

Issue Date FY: 2002 ( Subtotal = $248,763 )
2002	2002	HARVARD UNIVERSITY, SCHOOL OF MEDICINE	25 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Research Manpower	000	27	6/17/2002	NON-COMPETING CONTINUATION	$248,763
														Subtotal = $248,763

Issue Date FY: 2001 ( Subtotal = $240,118 )
2001	2001	HARVARD UNIVERSITY, SCHOOL OF MEDICINE	25 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Research Manpower	000	26	6/19/2001	NON-COMPETING CONTINUATION	$240,118
														Subtotal = $240,118

Issue Date FY: 2000 ( Subtotal = $255,731 )
2000	2000	HARVARD UNIVERSITY, SCHOOL OF MEDICINE	25 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Research Manpower	000	25	5/17/2000	NON-COMPETING CONTINUATION	$255,731
														Subtotal = $255,731

Issue Date FY: 1999 ( Subtotal = $255,476 )
1999	1999	HARVARD UNIVERSITY, SCHOOL OF MEDICINE	25 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Research Manpower	000	24	8/17/1999	COMPETING CONTINUATION	$255,476
														Subtotal = $255,476

Issue Date FY: 1998 ( Subtotal = $197,018 )
1998	1998	HARVARD UNIVERSITY, SCHOOL OF MEDICINE	25 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Research Manpower	000	23	7/20/1998	NON-COMPETING CONTINUATION	$197,018
														Subtotal = $197,018

Grand Total All Awards = $2,596,651

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VIRUS-HOST INTERACTIONS IN CANCER

Award Number: T32CA009031

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/1986

PERIOD OF PERFORMANCE END DATE: 05/31/2010

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