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Training program in the biology and translational research on Alzheimer's diseaseand related dementias

Award Number: T32AG057468
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/15/2017
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Training program in the biology and translational research on Alzheimer's diseaseand related dementias - Project Summary This T32 renewal application seeks support for the multidisciplinary education of trainees in Alzheimer’s disease and Related Dementia (ADRD). The goal of this program is to train the next generation of creative and meritorious ADRD researchers at the predoctoral level. We acknowledge that the development of future therapy for dementia will require strong training in multiple disciplines, such as, the molecular biology of dementia, drug discovery and development, clinical studies and the analysis of large data sets. We will answer the imperative need for scientists who can synthesize across disciplines. Our Training Program comprises of four disciplines/themes: (1) biological mechanisms (2) drug discovery and development (3) clinical ADRD (4) computational science. Each student gets trained in at least two of the four disciplines, utilizing a multidisciplinary approach for tackling scientific questions in ADRD. Attentive to the latest recommendation of the NIA and Alzheimer’s Association guidelines, there will be special emphasize on the analysis of lifestyle, environmental factors and preventative approaches for ADRD. The mentor/preceptor team has outstanding expertise to establish this innovative, interdisciplinary training program, to integrate otherwise disparate centers of excellence at UIC and Rush, leveraged by industry collaborations. Preceptor expertise is wide ranging; from molecular mechanisms of dementia, vascular biology, diabetes and inflammation, neuronal and neural imaging to clinical diagnosis of human ADRD patients and large scale data analysis. Expertise is from 12 departments and 6 clinical and translational entities. We will train ADRD researchers with expertise across multiple scientific fields and cross-disciplinary skills, including neuroscientists, but also computational biologists, chemists, and engineers interested in translational ADRD research. To facilitate interdisciplinary training, trainees will have two preceptors from different disciplines. We will build individual development plans (IDPs) for each trainee and offer multidisciplinary coursework from ADRD-TP faculty and pharma scientists. Importantly, trainees can perform translational research at any of the affiliated clinical and translational entities. Trainees will be encouraged to collaborate with large communitybased NIH-supported studies (ROS/MAP) or NIA’s large-scale collaborative consortia (AMP-AD, M2OVE-AD, ADNI, ACTC), and with our pharma partners, Eli Lilly, Abbott and Baxter. Trainees are encouraged to participate in workshops geared towards -omics and drug discovery and the CIM/MATTER entrepreneurial program that aids commercialization of scientific innovation. We seek to support 6 predoctoral trainees. The success of this program in the last five years is reflected by our alumni who have moved on to successful careers in academia and pharma. The ADRD-TP’s vitality is reflected by the numbers of highly qualified applicants and state-of-theart scientific endeavors and publications. We expect the next five year to surpass this success. In summary, the ADRD-TP will provide a rigorous, inspiring and nurturing environment to ensure training of the highest level of scientists needed to unravel dementia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $262,323 )
2026	2026	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Aging Research	000	9	7/16/2026	NON-COMPETING CONTINUATION	$262,323
														Subtotal = $262,323

Issue Date FY: 2025 ( Subtotal = $333,590 )
2025	2025	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Aging Research	000	8	8/22/2025	NON-COMPETING CONTINUATION	$333,590
														Subtotal = $333,590

Issue Date FY: 2024 ( Subtotal = $341,936 )
2024	2024	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Aging Research	002	7	7/3/2024	NON-COMPETING CONTINUATION	$341,936
2024	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Aging Research	001	6	2/21/2024	COMPETING CONTINUATION	$88,998
2024	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Aging Research	000	5	2/21/2024	NON-COMPETING CONTINUATION	-$88,998
														Subtotal = $341,936

Issue Date FY: 2023 ( Subtotal = $330,641 )
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Aging Research	002	6	5/1/2023	COMPETING CONTINUATION	$330,641
2023	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Aging Research	001	5	4/28/2023	NON-COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	5	11/11/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $330,641

Issue Date FY: 2021 ( Subtotal = $199,338 )
2021	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	5	8/11/2021	NON-COMPETING CONTINUATION	$199,338
														Subtotal = $199,338

Issue Date FY: 2020 ( Subtotal = $205,166 )
2020	2020	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	4	7/17/2020	NON-COMPETING CONTINUATION	$205,166
														Subtotal = $205,166

Issue Date FY: 2019 ( Subtotal = $194,931 )
2019	2019	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	3	7/25/2019	NON-COMPETING CONTINUATION	$194,931
														Subtotal = $194,931

Issue Date FY: 2018 ( Subtotal = $192,806 )
2018	2018	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	2	8/9/2018	NON-COMPETING CONTINUATION	$192,806
														Subtotal = $192,806

Issue Date FY: 2017 ( Subtotal = $190,732 )
2017	2017	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	1	9/13/2017	NEW	$190,732
														Subtotal = $190,732

Grand Total All Awards = $2,251,463

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Training program in the biology and translational research on Alzheimer's diseaseand related dementias

Award Number: T32AG057468

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/15/2017

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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