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Role of Water in Dental Hard Tissues

Award Number: SC3DE032298
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2022
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Role of Water in Dental Hard Tissues - Summary Water is one of the three major constituents of dental hard tissues, but the structure of water and how water interacts with other components in dental hard tissues during teeth formation, degradation, and lesion remain unclear. Nuclear magnetic spectrometry (NMR) and infrared absorption (IR) are the methods that can directly probe water from biological tissues. However, their performances are limited because NMR only measures the average effect of the sample, while IR requires special preparations to tissues like teeth and could alter the properties of the tissues. Recently, we demonstrated that fluorescence compressed Raman spectroscopy has the capability of probing water in dental hard tissues and showed that the spectral profiles of water are dramatically different between dentin and enamel. The profiles varied even within enamel at different testing spots. Those results indicate that Raman spectroscopy may provide additional information about the role of water in dental hard tissues with details that may impact the understanding of the mechanisms of dental problems. The major aim of the proposed project is to use Raman spectroscopy to identify how the changes in water content and structure in dental hard tissues may correlate with dental tissue pathologies. Aim 1 will determine the best available Raman spectroscopy configurations for probing water contents in dental hard tissues. Three common fluorescence suppression approaches, i.e., near-infrared excitation combining InGaAs detector, UV resonance Raman, and time-gated Raman spectroscopy will be compared to determine how the signal to noise ratio of the water-related Raman signals can be maximumly enhanced. We expect to increase the system sensitivity by one order or more. Aim 2 will investigate the changes in water amount and structure changes reflected by Raman spectroscopy and identify if these changes are correlated with other chemical/physical changes in dental hard tissues. Teeth with various degrees of demineralization and decomposing of organics will be prepared to show deferent levels of chemical compositional changes. Raman spectra will be acquired from these simulated samples and used as references for probing compositional variations in teeth with naturally developed caries. Raman spectroscopy will also be combined with micro-mechanical testing to identify correlations between water contents and structure change and mechanical property changes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $103,804 )
2025	2025	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST	JACKSON	MS	39217	HINDS	USA	Oral Diseases and Disorders Research	001	4	5/9/2025	NON-COMPETING CONTINUATION	$0
2025	2025	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST	JACKSON	MS	39217	HINDS	USA	Oral Diseases and Disorders Research	000	4	3/11/2025	NON-COMPETING CONTINUATION	$103,804
														Subtotal = $103,804

Issue Date FY: 2024 ( Subtotal = $105,204 )
2024	2024	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST	JACKSON	MS	39217	HINDS	USA	Oral Diseases and Disorders Research	000	3	1/22/2024	NON-COMPETING CONTINUATION	$105,204
														Subtotal = $105,204

Issue Date FY: 2023 ( Subtotal = $109,794 )
2023	2023	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Oral Diseases and Disorders Research	000	2	2/13/2023	NON-COMPETING CONTINUATION	$109,794
														Subtotal = $109,794

Issue Date FY: 2022 ( Subtotal = $97,350 )
2022	2022	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Oral Diseases and Disorders Research	000	1	4/13/2022	NEW	$97,350
														Subtotal = $97,350

Grand Total All Awards = $416,152

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Role of Water in Dental Hard Tissues

Award Number: SC3DE032298

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2022

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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