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Remediation of Perfluorinated Chemicals in Water Using Novel High-Affinity Polymer Adsorbents

Award Number: SB1ES029401
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Remediation of Perfluorinated Chemicals in Water Using Novel High-Affinity Polymer Adsorbents - Abstract Contamination of water supplies by toxic per- and polyfluoroalkyl substances is a major health and environmental issue impacting society today. Given the environmental persistence of these contaminants and their established linkage to serious health risks, it is imperative that safe, efficient, and cost-effective PFAS remediation technologies be developed that can eliminate these contaminants from the U.S. water supplies. With the tightening of health-based contamination limits and the expansion of regulated PFAS structures, the impacts of PFAS contamination are now estimated to affect over 200 million Americans. NIEHS sponsored DEXSORB adsorbent represents a breakthrough solution for the safe, rapid, and cost-effective removal of short- and long- chain PFAS compounds, including PFOA and PFOS from water. It takes exacting technology to remove PFAS compounds at the trace levels being mandated by States and the EPA. Made from renewable cyclodextrins, DEXSORB’s ability to selectively target PFAS compounds at trace concentrations with rapid uptake, high capacity, and resistance to fouling make it ideally suited for use in private and municipal water treatment systems. Working with environmental partners, Cyclopure has demonstrated the superior performance and favorable life cycle economies of DEXSORB in pilot water treatment activities. To advance further, specific milestones that upon completion will help Cyclopure transition to full commercialization stage have been identified in this CRP proposal. Cyclopure’s main objective in this program will be to seek support for regulatory and manufacturing assistance. Both areas are critical prior to the commencement of full-scale manufacturing and commercialization activities. Safety and health related information and associated experimental data will be collected and organized for material registrations and certifications as required by regulatory agencies including EPA and NSF International. Activities under manufacturing assistance will support developing an optimal purification method that is expected to provide significant cost and process improvements in a full-scale manufacturing environment. Successful completion of this proposed work will enable Cyclopure to transition to large-scale production and work with industry partners to make DEXSORB available to provide PFAS removal for consumer and municipal applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	CYCLOPURE, INC.	2430 N HALSTED ST FL 4	CHICAGO	IL	60614	COOK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	2/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $72,375 )
2023	2023	CYCLOPURE INC	171 SAXONY RD	ENCINITAS	CA	92024	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	8/8/2023	NON-COMPETING CONTINUATION	$72,375
														Subtotal = $72,375

Issue Date FY: 2022 ( Subtotal = $203,864 )
2022	2022	CYCLOPURE, INC.	171 SAXONY RD STE 208	ENCINITAS	CA	92024	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	4	9/6/2022	COMPETING CONTINUATION	$203,864
														Subtotal = $203,864

Grand Total All Awards = $276,239

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Remediation of Perfluorinated Chemicals in Water Using Novel High-Affinity Polymer Adsorbents

Award Number: SB1ES029401

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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