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Acquisition of a Matrix-Assisted Laser Desorption/Ionization Mass Spectrometer

Award Number: S10OD040197
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Acquisition of a Matrix-Assisted Laser Desorption/Ionization Mass Spectrometer - A team of NIH-funded investigators requests a Matrix-Assisted Laser Desorption/Ionization mass spectrometer (MALDI-MS), specifically an Autoflex maX TOF/TOF MALDI-MS from Bruker, a reliable instrument that fits the needs of most major and minor users. The instrument will be used to gain a deeper understanding of a broad range of molecules, including proteins, peptides, polymers, organic synthesis products, as well as sets of molecules such as proteomes and peptidomes from biological fluids. The MALDI-MS will be used for funded projects on the analysis of peptidomes in human serum and milk samples from donors with breast cancer and matched controls; analysis of secretomes of MCF7 cells with overexpressed or downregulated Jumping Translocation Protein, a cell cycle regulator and proto-oncogene; development of next-generation subcellular imaging reporters for organellar chloride using the “organelle chemotype fingerprinting” technique; determination of the role of a specific epithelial cell type residing in the developing intestinal stem cell compartment in zebrafish; elucidation of neural precursor communication during development of the Drosophila peripheral nervous system; development of a mouse model of tuberculosis that generates human-like pathology; determination of the effect of ferritin subunit composition on iron core formation and the roles of PCBP1 and NCOA4 in the fate of intracellular ferritin; and development of rugged, easy-to-use methods for analyte detection essential for environmental monitoring, food safety, high-throughput screening (HTS) of drug candidates, and disease diagnosis. There is no MALDI-MS within a 100-mile radius from Clarkson University. The new MALDI-MS will serve users from four Clarkson departments (Biology, Chemistry & Biomolecular Science/Chemistry & Biochemistry, Civil & Environmental Engineering, and Chemical & Biomolecular Engineering) as well as from four institutions located in northern New York State: the State University of New York (SUNY) at Potsdam, 2) SUNY at Plattsburgh, 3) St. Lawrence University in Canton, and 4) the Trudeau Institute at Saranac Lake. The MALDI-MS will be located in the Science Center and will become part of the Department of Chemistry & Biomolecular Science’s (Chemistry & Biochemistry) shared instrument facility, where it will be accessible to all Clarkson researchers and faculty and researchers from surrounding universities and institutes within a 100-mile radius. One highly experienced Associate Professor and Instrument Manager with full salary support from CBS will be responsible for the daily operation, weekly maintenance, new user training, as well as scheduling and charging users for instrument usage. The Instrument Manager’s managerial efforts will be complemented by the PI’s extensive expertise using MALDI-MS (beginning when he was a graduate student in Germany in 2000). Beyond the project period, Clarkson University will provide funds for MALDI-MS’s service contract, to ensure that the instrument is well maintained and to enable its use well beyond its standard lifetime.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $350,000 )
2026	2026	CLARKSON UNIVERSITY	8 CLARKSON AVE	POTSDAM	NY	13676	SAINT LAWRENCE	USA	Research Infrastructure Programs	000	1	8/31/2026	NEW	$350,000
														Subtotal = $350,000

Grand Total All Awards = $350,000

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Acquisition of a Matrix-Assisted Laser Desorption/Ionization Mass Spectrometer

Award Number: S10OD040197

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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