Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

High-Resolution Spatial Proteomics with a Hyperion XTi Imaging Mass Cytometer

Award Number: S10OD040159
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2026
PERIOD OF PERFORMANCE END DATE: 06/14/2027

Group Awards By:

View Award Description

High-Resolution Spatial Proteomics with a Hyperion XTi Imaging Mass Cytometer - PROJECT SUMMARY The Texas A&M Preclinical Phenotyping Core (TPPC) proposes the acquisition of the Hyperion XTi™ Imaging Mass Cytometry (IMC) System to enhance spatial proteomic imaging capabilities across the Texas A&M University (TAMU) research community and surrounding region. This advanced platform enables highly multiplexed, spatially resolved protein detection by using metal-tagged antibodies and time-of-flight mass spectrometry. Unlike fluorescence-based systems, the Hyperion XTi™ eliminates spectral overlap and autofluorescence, allowing for precise subcellular resolution and deep analysis of complex tissue environments. This system will fill a significant gap in TAMU’s imaging infrastructure, providing essential tools for high- content spatial analysis of disease progression, immune responses, and cellular interactions. Currently, no comparable technology exists on campus, and the nearest system is more than two hours away. TPPC is well positioned to implement the Hyperion XTi™ and begin offering services immediately. Under the leadership of Dr. Sunja Kim—an expert in histology and flow cytometry, with specialized training in imaging mass cytometry—TPPC has established and validated image analysis pipelines and gained hands-on experience in antibody panel design, tissue staining, and spatial data interpretation. To support daily operations, a dedicated technician with prior experience in Hyperion or CyTOF technology will be recruited to assist with system maintenance and data collection. Implementation will leverage TAMU’s coordinated inter-core structure. Expert contributions will include CyTOF panel design and antibody optimization from the Flow Cytometry Core (Dr. Gus Wright), and pathology- guided tissue evaluation from the Histology Core (Dr. Yava Jones-Hall). The TIGSS Bioinformatics Core will provide complementary support for image processing, data analysis workflows, and user training. While the system’s built-in software enables users to perform core analyses independently, the Bioinformatics Core will extend these capabilities for complex or large-scale projects, helping to ensure broad and effective adoption across research disciplines. With 99% of estimated user time already allocated and institutional commitments in place to support maintenance and operations, the proposed system will immediately benefit a large community of NIH-funded investigators. The Hyperion XTi™ will significantly elevate TAMU’s research infrastructure and enable transformative discoveries aligned with long-term goals in human health and disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $802,514 )
2026	2026	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Research Infrastructure Programs	000	1	6/11/2026	NEW	$802,514
														Subtotal = $802,514

Grand Total All Awards = $802,514

Top

All Categories

About

Search

Reports

Data Submission

Award Information

High-Resolution Spatial Proteomics with a Hyperion XTi Imaging Mass Cytometer

Award Number: S10OD040159

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2026

PERIOD OF PERFORMANCE END DATE: 06/14/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer