BD FACSDiscover S8 Spectral and Imaging Cell Sorter - PROJECT SUMMARY A group of eighteen NIH-funded investigators requests funding for the purchase of a BD FACSDiscoverTM S8 spectral and imaging cell sorter, for installation in the Cytometry and Cell Sorting Core at Baylor College of Medicine. These investigators use samples from a variety of species including humans, rats, and mice for their research in the fields of immunology, cancer biology, cardiovascular disease, cancer immunotherapy, virology, parasitology, and neuroscience. Besides the users from two different institutions listed in this application, the instrument will be accessible, through an existing memorandum of understanding, at internal cost to all investigators at Baylor College of Medicine and the Texas Medical Center. Baylor College of Medicine, Rice University, the University of Houston, the University of Texas Health Science Center at Houston, the University of Texas M.D. Anderson Cancer Center, the University of Texas Medical Branch at Galveston, and the Texas A&M Health Science Center - Institute of Biosciences and Technology.