A Theranostic, Multiparticle, National Cyclotron Resource at UW-Madison - Project Summary / Abstract The Cyclotron Research Group in the School of Medicine and Public Health (SMPH) Department of Medical Physics stewards a GE PETtrace 16 MeV proton / 8 MeV deuteron cyclotron in the Wisconsin Institutes for Research and Discovery whose capacity and capabilities have become insufficient to meet growing demand for theranostic radionuclides. The group has a four-decade history of achievement in research, training, and revenue-neutral service provision as an institutional and national resource in radionuclide production. Building on a successful C06 award in 2023, funding is requested to purchase a 30XP multiparticle cyclotron manufactured by Ion Beam Applications (IBA) of Louvain la Neuve, Belgium. This machine accelerates extractable negative ion proton and deuteron beams with maximum beam intensities of 400 and 50 µA, respectively, and can be configured in positive ion mode to accelerate alpha beams up to 50 µA. The machine has variable position stripping foil mounts to feed each of two extraction ports, creating the option for nominal variable energy for the proton (15-30 MeV) and deuteron (8-15 MeV) beams. The machine will be configured with three primary target end stations, each servedby a combination of switching magnets and multiple-quadrupole focusing elements. A five-port switching magnet on the first extraction port of the vacuum tank will send beam to one of five individual targets at a time, enabling rapid switching between targets for 18F, 11C, a dummy for accelerator developing and beam tuning, and two oblique, coin-type solid target stations that can each produce a wide range of isotopes (64/67Cu, 89Zr, 52g/51Mn, 86Y, 55Co, 117/119Sb, 45Ti, 43/44/47Sc, 203Pb, 201Tl, and many others) needed by biomedical researchers. The second extraction port’s beam will be split by a selection magnet in the main vault and directed to an independently-accessed secondary vault with two high-current (>100 µA) end stations homing glancing incidence solid targets. Each beam line is equipped with dual quadrupole magnets and beam “wobblers” to distribute the intense thermal power these target stations can tolerate. Wire scanning and phosphorescent screen beam profile monitors will be equipped on each beamline to ensure quantitative intercept of the beam’s transverse profile by the desired target material. All target stations will be equipped with remote transport solutions that feed radiochemical hot cells in adjacent laboratories. The variable extraction system will also be capable of extracting user-selectable fractions of the beam, thereby allowing simultaneous beam delivery at a single energy to both extraction ports, dramatically increasing the flexibility of production scenarios. The combination of infrastructure described will more than quadruple available quantities of standard positron- and single photon-emitting radionuclides for imaging and make new therapeutic radionuclides (especially radiometals from solid target irradiations). These materials are needed by over 40 current awards distributed between local UW and national components of the user base and will also support the education and training mission of the Group and multiple T32 awards.
