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CAGT Shared Instrumentation Grant: IncuCyte SX5 Imaging System

Award Number: S10OD036406
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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CAGT Shared Instrumentation Grant: IncuCyte SX5 Imaging System - PAR: 22-080 S10 Biomedical Research Support Shared Instrumentation Grants CAGT Shared Instrumentation Grant: IncuCyte SX5 Imaging System Project Summary/Abstract The development of cell and gene therapies to target cancer has revolutionized the approach to treat patients with blood cancers. However, this treatment has had little effect on the treatment of solid tumors which comprise about 90% of all cancers. Therefore, novel strategies to develop therapies must be considered and multiparametric evaluation of those products are critical to understand their functionality. Utilizing state-of-the-art technology such as live-cell image analysis in complex models will provide improved accuracy and consistent testing of current and future products that will translate to the treatment of patients. We aim to purchase a new IncuCyte SX5 with funds provided through the Shared Instrument Grant application that can be used in the Center for Cell and Gene Therapy (CAGT). The IncuCyte is a live cell imaging system that allows easy quantification of cell morphology and behavior over time. The SX5 provides up to five color fluorescent imaging with the capability of three-color multiplexing compared to the current two-color fluorescence with the S3 model. This instrument improves productivity by allowing automatic acquisition and analysis for up to six culture plates or vessels in parallel. Analyses include the visualization and quantification of cell proliferation, tumor and immune cell interactions, cytotoxicity, cell type specific metabolic activity, and three-dimensional tumor spheroid assays. The SX5 increases the flexibility of experimental parameters and reagents when evaluating complex therapies developed by investigators at CAGT. Novel evaluations with the IncuCyte SX5 will prove to be invaluable to assess the functionality of cell and gene therapy products for clinical translation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $248,962 )
2025	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	000	1	7/30/2025	NEW	$248,962
														Subtotal = $248,962

Grand Total All Awards = $248,962

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CAGT Shared Instrumentation Grant: IncuCyte SX5 Imaging System

Award Number: S10OD036406

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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