Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Upgrade of the 11.7T Research Scanner at the F.M. Kirby Research Center

Award Number: S10OD032188
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2025

Group Awards By:

View Award Description

Upgrade of the 11.7T Research Scanner at the F.M. Kirby Research Center - We propose to upgrade the 11.7T horizontal bore Bruker animal scanner at the F.M. Kirby Research Center of the Hugo Moser Research Institute at Kennedy Krieger (KKI) from the current AVANCE IIIHD generation (installed in 2011 and no longer supported after 2024) to the AVANCE NEO generation. Multiple parts of the scanner have been failing and will have surpassed their expected lifetime after 2024. Scanner replacement is necessary to keep providing working and state-of-the-art equipment to the many investigators at KKI and Johns Hopkins University (JHU), who have 15 NIH- funded grants and 2 other grants with specific aims that strongly benefit from the technical capabilities provided by this upgrade. These investigators use the 11.7T system for structural MRI, functional MRI (fMRI), quantitative physiological MRI, magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI), advanced diffusion imaging approaches, and chemical exchange saturation transfer (CEST) MRI for the study of animal models for a large range of diseases and disabilities. The main hardware features of importance for us in the NEO upgrade are the new 8-channel transceiver system and the high-performance high-duty cycle combined gradient/shim system with 1- µs gradient waveform generation. In addition, we are requesting several coils, coil accessories, and a high-end animal monitoring unit for optimal experiments for our users. These combined upgrades will bring us again to state-of-the-art MRI hardware with respect to commercially available optimal magnetic field gradient performance and multi-channel whole-body transceive capabilities (both homonuclear and heteronuclear), including the latest coils and accessories. In addition, our 14-year old computer would be upgraded and the Paravision 6 software replaced by Paravision 360, which would provide us with additional advanced data acquisition and processing software, including for instance: in-plane parallel imaging, simultaneous multi-slice (SMS) imaging with multi-band (MB) pulses, as well as reduced k-space acquisition approaches such as compressed sensing (CS). This upgrade will provide multiple benefits for our users, including but not limited to: reduced echo time TE and repetition time TR, improved SNR, and greatly increased speed when using in- plane acceleration, SMS, or CS. Other advantages are reduced spatial distortion, improved B1 and B0 homogeneities, real time updating for dynamic shimming, drift compensation and motion monitoring. Improved frequency stability will provide benefits for a) improved signal intensity stability for dynamic scans; b) absence of spatial image drift under high duty cycle gradient use such as in high-angular multi-shell diffusion imaging; c) reduced spatial broadening and improved spectral editing with selective pulse excitation for MRS; d) improved CEST frequency referencing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Research Infrastructure Programs	000	1	4/14/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,708,938 )
2024	2024	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Research Infrastructure Programs	000	1	2/29/2024	NEW	$1,708,938
														Subtotal = $1,708,938

Grand Total All Awards = $1,708,938

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Upgrade of the 11.7T Research Scanner at the F.M. Kirby Research Center

Award Number: S10OD032188

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer