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Sciex TripleTOF 6600+ system mass spectrometer and dedicated in-line EKSPERT nanoLC 425 liquid chromatographic system

Award Number: S10OD028508
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2020
PERIOD OF PERFORMANCE END DATE: 09/19/2021

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Sciex TripleTOF 6600+ system mass spectrometer and dedicated in-line EKSPERT nanoLC 425 liquid chromatographic system - Maine Medical Center has long been a leader in innovative healthcare, and has a strong tradition of clinical scholarly activity. Our investigator-initiated, extramurally funded biomedical research capacity has largely been developed in the past 15 years, due to a combination of deliberate and strategic institutional investments and invaluable support provided by the NIH Institutional Development Award (IDeA) program. In 1995, Maine Medical Center essentially did not have NIH-funded research programs. However, we had early success in attracting funding through the Center for Biomedical Research Excellence (COBRE) program, with programs in Angiogenesis/Vascular Biology, Stem Cell and Progenitor Cell Biology, and a current COBRE program in Metabolic Networks. These COBRE programs have built a rigorous basic science focus at our center, with current strategic growth in translational and clinical research. This was recently bolstered by our IDeA-funded Northern New England Clinical and Translational Research Center. An integral component of our research programs are scientific core facilities. For the past 18 years, we have been growing our mass spectrometry facility, and currently have a highly functioning resource that focuses on analytical methods for protein and lipid analysis. Our goals are to provide new approaches that expand protein identification capabilities, provide isotope-free quantitative protein analysis, enable broad unbiased lipid profiling of cells and tissues, enable targeted lipid quantification, and improve statistical methods for data interpretation. Our existing system utilizes a Sciex TripleTOF 5600 mass spectrometer, which is in constant use and is unable to meet the growing demands for both proteomic and lipidomic analyses. To ensure completion of NIH-funded research, to expand our analytic capabilities, and to accelerate the pace of research, this proposal seeks funds to purchase a Sciex TripleTOF 6600+ system mass spectrometer and dedicated in-line EKSPERT nanoLC 425 liquid chromatographic system and associated gas generator. This instrument would both upgrade and expand upon the current TripleTOF 5600 as our chief “discovery” platform, driving innovative new areas of study. Specific features that are required for our ongoing proteomics research projects that are embodied in the Sciex TripleTOF 6600+ include: a) the OptiFlow TurboV source, b) the OptiFlow interface, c) ultra-fast TripleTOF scan speeds, and d) advanced SWATH acquisition workflows. The TripleTOF 6600+ offers advanced “next generation” workflows that are not available with the TripleTOF 5600, including support for high-speed high- window density scanning SWATH. We expect that the purchase of the TripleTOF 6600+ will ensure the ongoing productive functioning of our facility and will produce data of the highest achievable rigor and quality, with speed of acquisition and mass resolution that exceeds current capabilities, and will support a wide range of biomedical studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$851 )
2022	2020	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Research Infrastructure Programs	000	1	3/29/2022	NEW	-$851
														Subtotal = -$851

Issue Date FY: 2020 ( Subtotal = $542,219 )
2020	2020	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Research Infrastructure Programs	000	1	9/11/2020	NEW	$542,219
														Subtotal = $542,219

Grand Total All Awards = $541,368

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Sciex TripleTOF 6600+ system mass spectrometer and dedicated in-line EKSPERT nanoLC 425 liquid chromatographic system

Award Number: S10OD028508

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2020

PERIOD OF PERFORMANCE END DATE: 09/19/2021

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