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PREP-TALK: Transforming Hospitalization into a PrEP Engagement Opportunity for People Who Use Drugs

Award Number: RM1DA066198
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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PREP-TALK: Transforming Hospitalization into a PrEP Engagement Opportunity for People Who Use Drugs - PROJECT SUMMARY People who use drugs (PWUD), such as opioids and stimulants, are at increased risk for HIV. Pre-exposure prophylaxis (PrEP) is a highly effective and safe medication available in pills or long-acting injectable form which reduces the risk of HIV. However, current norms confine PrEP prescribing to outpatient settings. This creates a gap in care for PWUD who have low uptake of PrEP and are often disconnected from outpatient healthcare systems. Hospitalization has emerged as a critical touchpoint to engage PWUD in multiple aspects of preventative healthcare but has not been previously examined as an access point for PrEP. Successfully integrating PrEP into inpatient care requires systematic implementation strategies that address multilevel barriers and facilitators within hospital systems. There is an urgent need to develop, implement and test systems for integrating PrEP prescriptions into hospital workflows, discharge planning, and linkage to community resources for long-term follow-up. In response to RM1 Funding Opportunity DA-25-060, our team of six MPIs will leverage four geographically and demographically diverse hospital sites in Boston, St. Louis, Chapel Hill and San Francisco to shift the paradigm of HIV prevention for PWUD by moving PrEP from a purely outpatient consideration to a routine part of inpatient care. We will use a Consolidated Framework for Implementation Research to methodically introduce academic detailing, an evidence-based educational strategy that uses trained health professionals to deliver targeted outreach to clinicians, to support the uptake of PrEP prescribing best practices. We hypothesize that an academic detailing toolkit, informed by community preferences and optimized through human-centered design can shift the paradigm of HIV prevention for PWUD by leveraging the strategic positioning of the hospital as an accessible healthcare node to screen for HIV and initiate PrEP, increasing retention in PrEP care. In Aim 1, we will develop, refine and pilot an inpatient PrEP academic detailing toolkit entitled PrEP-Talk. We will utilize participatory human-centered design workshops with a multi-tiered Community Advisory Board (CAB) comprising clinicians and PWUD to co-create toolkit components, including academic detailing training, clinician and peer education, and patient-facing materials. In Aim 2 we will evaluate the effectiveness of PrEP-Talk on PrEP uptake among hospitalized PWUD, and in Aim 3 we will evaluate implementation outcomes of PrEP-Talk. Our findings have the potential to identify a novel intervention and methodology to increase PrEP uptake and retention in a population where need remains high, providing a scalable, evidence-based pathway to end the HIV epidemic.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,066,706 )
2026	2026	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	1	7/20/2026	NEW	$2,066,706
														Subtotal = $2,066,706

Grand Total All Awards = $2,066,706

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PREP-TALK: Transforming Hospitalization into a PrEP Engagement Opportunity for People Who Use Drugs

Award Number: RM1DA066198

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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