Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Stimulant and Polysubstance use, Inflammation and Sex Effects on Myocardial Disease in HIV (SPISE)

Award Number: RM1DA063351
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2025
PERIOD OF PERFORMANCE END DATE: 03/31/2030

Group Awards By:

View Award Description

Stimulant and Polysubstance use, Inflammation and Sex Effects on Myocardial Disease in HIV (SPISE) - PROJECT SUMMARY/ABSTRACT Heart failure (HF) and other cardiovascular diseases (CVDs) constitute a leading cause of death in people with HIV (PWH). Compared to people without HIV, PWH have greater HF risk and we have shown that the difference in risk may be greater in women than men. However, traditional HIV and CVD risk factors do not fully explain the higher HF risk. Notably, symptomatic HF is often preceded by subclinical changes in left ventricular structure and function detectable by echocardiography (echo), and even sooner by cardiac magnetic resonance imaging (CMR). Recognizing myocardial disease determinants and the mechanistic contributors early in the disease process is imperative to identify targets for HF prevention and treatment in PWH. Controlled stimulants like cocaine and methamphetamine are known cardiotoxins, but their role in myocardial remodeling among PWH is unclear. Stimulant use is higher among PWH than the general population, yet stimulant use is poorly assessed in large HIV and CVD studies. It is either pooled with other substances or lacks details about patterns of use, level of exposure, and synergistic influences with other substances – hampering our ability to understand the potentially outsized role of stimulant use in the pathogenesis of HIV and myocardial disease in PWH. We propose “Stimulant and Polysubstance use, Inflammation, and Sex Effects on Myocardial Disease in HIV (SPISE)” a research program within the Multicenter AIDS Cohort Study (MACS)/Women’s Interagency HIV Study (WIHS) Combined Cohort Study. Our findings from WIHS suggest that sustained (and not any) self-reported substance use is associated with cardiac dysfunction, and sustained cannabis may have a protective effect, emphasizing a need to assess substance use patterns and different influences of multiple substances. Furthermore, women with HIV who reported prior cocaine use may have a larger HIV-1 reservoir than never users, even after adjusting for ART adherence, which could explain persistent viremia in some women with implications to inflammation and epigenetic maladaptation. SPISE’s overarching research goal is to rigorously characterize substance use patterns (using serial urine drug toxicology measures and self-report) and determine its effect on structural heart disease and myocardial disease through the longitudinal SPICE-echo and prospective SPICE-CMR studies, respectively; whether DNA methylation and the inflammatory proteome mediates these effects; and how HIV and sex influence the pathways. SPISE will establish a transdisciplinary infrastructure to comprehensively investigate the biological basis of substance-associated myocardial disease at multiple points of the mechanistic pathway. Our findings will be shared with the scientific community to stimulate and sustain research in substance use and HIV. SPISE has the potential to transform current research paradigms that do not consider independent stimulant use effects, promote new approaches for implementation research that acknowledge the importance of substance use patterns, inform biomedical and behavioral interventions that are sex-specific, and direct resource-intensive risk reduction strategies to those PWH who use substances and are at highest CVD risk.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,278,072 )
2026	2026	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST # 151	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Drug Use and Addiction Research Programs	001	2	3/26/2026	NON-COMPETING CONTINUATION	$2,278,072
2026	2025	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST # 151	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Drug Use and Addiction Research Programs	000	1	2/5/2026	NEW	$0
														Subtotal = $2,278,072

Issue Date FY: 2025 ( Subtotal = $1,969,877 )
2025	2025	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST # 151	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Drug Use and Addiction Research Programs	001	1	7/29/2025	NEW	$0
2025	2025	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST # 151	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Drug Use and Addiction Research Programs	000	1	7/9/2025	NEW	$1,969,877
														Subtotal = $1,969,877

Grand Total All Awards = $4,247,949

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Stimulant and Polysubstance use, Inflammation and Sex Effects on Myocardial Disease in HIV (SPISE)

Award Number: RM1DA063351

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2025

PERIOD OF PERFORMANCE END DATE: 03/31/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer