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Collaborative Pediatric Critical Care Research Network - Clinical Site

Award Number: RL1HD107781
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/18/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Collaborative Pediatric Critical Care Research Network - Clinical Site - PROJECT SUMMARY/ABSTRACT – Children’s National Hospital Discovery of new therapeutic approaches to save the lives and improve the recovery of children with critical illnesses can have profound effects on the child, the family and the overall health care system. In the past decades, studies – often from a single center or a small number of centers - have led to intriguing hypotheses that may result in benefits for a wide number of conditions. However, fully testing these putative therapies has been hampered by an inability to enroll adequate number of subjects, mobilize sufficient trained personnel to conduct the study and garner enough resources to fully answer the question. Children’s National Hospital (CNH) is enthusiastic to join the new Collaborative Pediatric Critical Care Network (CPCCRN) to perform the innovative studies for children with multiple organ failure after sepsis. CNH has been proud to be a part of the 3 previous CPCCRN cycles starting in 2004. As a clinical center with over 4000 ICU admissions each year while serving a diverse community in the Washington/Maryland/Virginia region, we stand uniquely poised to enroll subjects in innovative clinical studies. By including children from our center, from our ancillary site (Children’s Hospital of Richmond [CHoR]) and the other 22 sites within this new CPCCRN, sufficient numbers of children will be available for enrollment and ensure the generalizability of the findings. We bring an experienced research team to this new project. Our PI team is experienced at research, specialists in neurological and cardiac critical care and leaders at CNH. In these capacities, they will identify and support young investigators to participate in CPCCRN activities while also ensuring the success of the project(s) within CPCCRN. The PIs have been deeply involved with the preliminary studies that have led up to the proposed studies of personalized medicine to treat children with multiple organ failure. We believe this novel approach will finally advance the field past the hurdle of only being able to use “supportive” care for such patients and lead to substantial improvements in overall function, quality of life and family functioning. Moreover, we believe that new, funded projects can be brought into CPCCRN by investigators within our center to make further advances in the field of pediatric critical care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $178,032 )
2025	2025	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	002	5	9/2/2025	NON-COMPETING CONTINUATION	$178,032
2025	2024	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	001	4	8/26/2025	NON-COMPETING CONTINUATION	$0
2025	2024	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	4	7/15/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $178,032

Issue Date FY: 2024 ( Subtotal = $176,252 )
2024	2024	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	4	8/28/2024	NON-COMPETING CONTINUATION	$176,252
														Subtotal = $176,252

Issue Date FY: 2023 ( Subtotal = $178,032 )
2023	2023	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	3	8/5/2023	NON-COMPETING CONTINUATION	$178,032
														Subtotal = $178,032

Issue Date FY: 2022 ( Subtotal = $178,032 )
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	001	2	7/18/2022	NON-COMPETING CONTINUATION	$178,032
2022	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	1	7/11/2022	NEW	$0
														Subtotal = $178,032

Issue Date FY: 2021 ( Subtotal = $178,032 )
2021	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	1	8/17/2021	NEW	$178,032
2021	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	001	1	9/8/2021	NEW	$0
														Subtotal = $178,032

Grand Total All Awards = $888,380

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Collaborative Pediatric Critical Care Research Network - Clinical Site

Award Number: RL1HD107781

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/18/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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