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Collaborative Pediatric Critical Care Research Network - Clinical Site

Award Number: RL1HD107773
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/18/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Collaborative Pediatric Critical Care Research Network - Clinical Site - Project Summary In 2005, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) established the Collaborative Pediatric Critical Care Research Network (CPCCRN) to support multi-institutional randomized controlled trials (RCTs) and observational studies in critically ill children. The ongoing PeRsonalizEd immunomodulation in pediatriC sepsIS-inducEd MODS (PRECISE) Study is the central project for the current CPCCRN funding cycle and is evaluating a precision medicine approach to sepsis-induced multiple organ dysfunction syndrome (MODS). Sepsis-induced organ dysfunction is a leading killer of children worldwide, resulting in over 3 million pediatric deaths per year. Current pediatric sepsis management is largely focused on antibiotics and supportive care including fluid resuscitation and the use of vasoactive drugs. Except for titration of vasoactive support based on hemodynamics, there are no recommended treatment approaches that are personalized to the individual septic child’s pathophysiology. Our network has systematically collected data from hundreds of septic children across multiple pediatric centers clearly showing that children with sepsis-induced MODS have distinct pathophysiologic immune phenotypes that we hypothesize could benefit from personalized care. We have developed the laboratory infrastructure to rapidly diagnose these phenotypes, allowing, for the first time, the creation of interventional protocols that are personalized to an individual septic child’s immune state. This approach is being evaluated through the CPCCRN in the PRECISE Study. The PRECISE Study is highly innovative and includes an immunophenotype-driven placebo controlled RCT and three prospective, observational studies that will address the central hypothesis that individualized, pathophysiology-specific immunomodulation will improve outcomes from sepsis-induced MODS in children. Although the current CPCCRN funding cycle was designed primarily to support PRECISE, the network has leveraged its centralized phenotyping infrastructure, biospecimen repository, and multicenter clinical research framework to support a substantially broader scientific portfolio. There are four NIH-funded ancillary studies that are currently utilizing PRECISE data and biospecimens and an independent NICHD-funded multi-center trial of pain management in intubated children. Successful completion of this supplement period will allow CPCCRN and NICHD to complete one of the largest and most innovative precision medicine studies ever conducted in pediatric critical care while sustaining a mature national research infrastructure capable of supporting multicenter clinical trials, translational science, and investigator development. In addition to generating critically important data regarding personalized immunomodulatory approaches for pediatric sepsis-induced MODS, CPCCRN will continue to serve as a highly productive platform for ancillary studies, biospecimen-based discovery science, and future investigator-initiated trials aimed at improving outcomes for critically ill children.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $143,916 )
2026	2026	CENTRAL MICHIGAN UNIVERSITY	1200 S FRANKLIN ST	MOUNT PLEASANT	MI	48859	ISABELLA	USA	Child Health and Human Development Extramural Research	001	5	8/18/2026	SUPPLEMENT FOR EXPANSION	$143,916
2026	2025	CENTRAL MICHIGAN UNIVERSITY	1200 S FRANKLIN ST	MOUNT PLEASANT	MI	48859	ISABELLA	USA	Child Health and Human Development Extramural Research	000	5	8/11/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $143,916

Issue Date FY: 2025 ( Subtotal = $143,916 )
2025	2025	CENTRAL MICHIGAN UNIVERSITY	119 BOVEE UNIVERSITY CTR	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Child Health and Human Development Extramural Research	000	5	7/15/2025	NON-COMPETING CONTINUATION	$143,916
														Subtotal = $143,916

Issue Date FY: 2024 ( Subtotal = $142,477 )
2024	2024	CENTRAL MICHIGAN UNIVERSITY	119 BOVEE UNIVERSITY CTR	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Child Health and Human Development Extramural Research	000	4	8/29/2024	NON-COMPETING CONTINUATION	$142,477
														Subtotal = $142,477

Issue Date FY: 2023 ( Subtotal = $143,916 )
2023	2023	CENTRAL MICHIGAN UNIVERSITY	119 BOVEE UNIVERSITY CTR	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Child Health and Human Development Extramural Research	000	3	8/14/2023	NON-COMPETING CONTINUATION	$143,916
														Subtotal = $143,916

Issue Date FY: 2022 ( Subtotal = $143,916 )
2022	2022	CENTRAL MICHIGAN UNIVERSITY (INC)	119 BOVEE UNIVERSITY CENTER	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Child Health and Human Development Extramural Research	001	2	7/22/2022	NON-COMPETING CONTINUATION	$143,916
2022	2021	CENTRAL MICHIGAN UNIVERSITY (INC)	119 BOVEE UNIVERSITY CENTER	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Child Health and Human Development Extramural Research	000	1	7/15/2022	NEW	$0
														Subtotal = $143,916

Issue Date FY: 2021 ( Subtotal = $143,916 )
2021	2021	CENTRAL MICHIGAN UNIVERSITY (INC)	119 BOVEE UNIVERSITY CENTER	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Child Health and Human Development Extramural Research	001	1	9/8/2021	NEW	$0
2021	2021	CENTRAL MICHIGAN UNIVERSITY (INC)	119 BOVEE UNIVERSITY CENTER	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Child Health and Human Development Extramural Research	000	1	8/17/2021	NEW	$143,916
														Subtotal = $143,916

Grand Total All Awards = $862,057

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Collaborative Pediatric Critical Care Research Network - Clinical Site

Award Number: RL1HD107773

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/18/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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