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A Computational Framework for Distributed Registration of Massive Neuroscience Images

Award Number: RF1MH126732
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2021
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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A Computational Framework for Distributed Registration of Massive Neuroscience Images - Project Summary Neuroscience stands at the precipice of a new depth of understanding about how the brain works thanks to recent advances in imaging data acquisition technologies such as light-sheet ﬂuorescence microscopy (LSFM). How- ever, the lack of analytic tooling to mine this rich information's relationship across samples, timepoints, and data acquisition technologies prevents researchers from unlocking quantitative relationships. We propose the creation of an easy-to-use, distributed-computation image registration tools that will map large images into a common reference frame. This work will be based on the open source Insight Toolkit (ITK), a widely supported, standard library for reproducible, computational image analysis. We propose extending ITK's registration architecture with technologies and methods from deep learning and the scientiﬁc Python community to effectively register LSFM volumes and time series. This project has the potential to integrate recent advances in cell typing and circuit mapping that will ultimately elucidate the underlying mechanisms of brain development and function.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	KITWARE INC	1712 ROUTE 9	HALFMOON	NY	12065	SARATOGA	USA	Mental Health Research Grants	000	1	1/4/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	KITWARE INC	1712 ROUTE 9	HALFMOON	NY	12065	SARATOGA	USA	Mental Health Research Grants	000	1	6/5/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $1,365,152 )
2021	2021	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Mental Health Research Grants	000	1	7/15/2021	NEW	$455,545
2021	2021	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Mental Health Research Grants	001	1	7/28/2021	NEW	$909,607
														Subtotal = $1,365,152

Grand Total All Awards = $1,365,152

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A Computational Framework for Distributed Registration of Massive Neuroscience Images

Award Number: RF1MH126732

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2021

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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