Friday, April 4, 2025 4/4/2025

From synapses to genes through morphology: an integrated characterization of cell types based on connectomics and transcriptomics data

Award Number: RF1MH125932
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

From synapses to genes through morphology: an integrated characterization of cell types based on connectomics and transcriptomics data - Project Summary The goal of this project is to create a unified framework for understanding the relationship between neuronal gene expression and connectivity in mouse visual cortex, by using morphology as a key linking modality. There now exist publicly available large-scale data sets that measure both these modalities in mouse visual cortex. One dataset is a large set of Patch-seq experiments from single cells, which provide measurements of gene expression, electrophysiological properties and morphology for individual cells. A second dataset is from large scale Connectomics using electron microscopy, which provides neuronal morphology; fine-scale and detailed cellular and ultrastructural properties; and measurements of the connectivity between individual neurons. Our first aim is to analyze these two datasets in an explicitly integrative fashion, in order to build better classifiers of neuronal types, along with tools to translate type predictions between each data modality. Our second aim builds on the first, by using those tools to characterize cell-type specific connectivity of mouse visual cortex. This will allow us to describe how that connectivity relates to the likely molecular composition of individual cells and provide insight into which molecular distinctions drive differences in cell type specific connectivity patterns. Our third aim is to redistribute the results of our analysis back into publicly available data repositories and create tools that allow other researchers to query the gene expression, connectivity, electrophysiological and morphological descriptors of neurons in the datasets, as well as apply those same tools to their own data. Like a Rosetta stone for cell types, this will enable researchers using disparate methods to integrate their data with other modalities and foster a rich environment for understanding the role of cell types in brain function and disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	ALLEN INSTITUTE	615 WESTLAKE AVE N	SEATTLE	WA	98109	KING	USA	Mental Health Research Grants	000	1	2/11/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $1,441,184 )
2021	2021	ALLEN INSTITUTE	615 WESTLAKE AVE N	SEATTLE	WA	98109	KING	USA	Mental Health Research Grants	000	1	9/15/2021	NEW	$1,441,184
														Subtotal = $1,441,184

Grand Total All Awards = $1,441,184

Top

All Categories

About

Search

Reports

Data Submission

Award Information

From synapses to genes through morphology: an integrated characterization of cell types based on connectomics and transcriptomics data

Award Number: RF1MH125932

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer