Monday, October 13, 2025 10/13/2025

Genetic and genomic effects of increased transposition

Award Number: RF1AG086692
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Genetic and genomic effects of increased transposition - PROJECT SUMMARY Aging can be defined as the progressive gradual decline in physiological function. It is the major risk factor for human pathologies that lead to disease, morbidity and mortality. Therefore, a better understanding of aging and the processes that affect lifespan at the molecular level remains an important problem in modern biology and medicine. Recent observations have highlighted a potential new process as a possible driver of aging and age- associated disease. As an organism ages, retrotransposon mRNA expression increases. What is lacking, at this point, is an understanding of how this retrotransposon expression can cause aging and aging-related phenotypes. Drosophila has long served as a very useful model system to understand the molecular underpinnings of aging. In addition to a relatively short lifespan, Drosophila has well-developed genetic tools and a long history of observations of the effects of age on the organism. To complement this is a long history of work to understand transposon biology in this organism. This makes Drosophila particularly well-suited to set up a new model to understand the role of retrotransposon activity in aging and aging-related phenotypes. The goals of this project are to set up and characterize a Drosophila system to understand whether transposon activity is a cause or effect of aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $985,375 )
2025	2025	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Aging Research	000	2	9/19/2025	EXTENSION WITH OR WITHOUT FUNDS	$985,375
														Subtotal = $985,375

Grand Total All Awards = $985,375

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Genetic and genomic effects of increased transposition

Award Number: RF1AG086692

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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