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COSMIC: An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethno-racial groups and geographical settings

Award Number: RF1AG057531
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract The best approach to identify risk and protective factors, and develop early biomarkers, of cognitive decline and dementia in older people is to conduct prospective longitudinal studies of aging in representative cohorts from the population. Many such studies are being conducted around the world. For practical reasons, no single study can have a large enough sample and sufficient power to detect modest-sized effects, or to compare rates, proportions, and antecedents in a large variety of populations. Further, these studies have used disparate methodologies, and even small variations in methodology make results difficult to compare across populations. This grant proposal is to support a consortium – COSMIC (COhort Studies of Memory in International Consortium) – that was established in 2012 and now includes 26 studies from 16 countries in five continents, with a combined sample size of >70,000. The leaders of these studies have agreed to pool de- identified data from these studies. The data harmonization strategy in COSMIC offers the potential to explore both existing and novel research questions by creating a single, large database to help minimize the influence of both study-level (e.g. methodology) and individual level (e.g. demographic) factors, while also enabling these to be explored as potential contributors to differences in results . Other advantages include increased statistical power for detecting effects of modest size, and the inherent replication and enhanced generalizability associated with using heterogeneous samples and methodologies. COSMIC will address many extant questions in the analytical epidemiology of cognitive aging and dementia. It will help examine the rates and patterns of cognitive decline in aging populations in diverse geographical regions and ethno-racial groups, and determine the prevalence and incidence of neurocognitive disorders in these settings. It will inform us which risk and protective factors are universal and others that are specific to certain populations. Novel factors may thereby be identified. Biomarkers of dementia can similarly be examined. The cohorts will permit the examination of decline in individuals who have been diagnosed with dementia, and the burden these disorders pose on the health care systems in different countries. COSMIC is a truly international effort. The rules of engagement have been established and the success of the first two projects has demonstrated its feasibility. This grant proposal is to help ensures its financial viability as it continues to grow to make a lasting impact on the epidemiology of cognitive aging and dementia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$138,672 )
2023	2020	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON				AUS	Aging Research	000	1	10/1/2022	SUPPLEMENT FOR EXPANSION	-$138,672
														Subtotal = -$138,672

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW			AUS	Aging Research	001	1	1/31/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2017	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW			AUS	Aging Research	000	1	1/31/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $295,969 )
2020	2020	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW	2052		AUS	Aging Research	001	1	3/31/2020	SUPPLEMENT FOR EXPANSION	$295,969
2020	2020	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW	2052		AUS	Aging Research	002	1	4/27/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2017	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW	2052		AUS	Aging Research	000	1	12/9/2019	NEW	$0
														Subtotal = $295,969

Issue Date FY: 2017 ( Subtotal = $2,573,572 )
2017	2017	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW	2052		AUS	Aging Research	000	1	9/13/2017	NEW	$2,573,572
														Subtotal = $2,573,572

Grand Total All Awards = $2,730,869

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COSMIC: An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethno-racial groups and geographical settings

Award Number: RF1AG057531

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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