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Apolipoprotein E2 and Brain Aging

Award Number: RF1AG056499
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2021

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Apolipoprotein E2 and Brain Aging - PROJECT SUMMARY/ABSTRACT This proposed effort is offered in response to NIH Funding Opportunity Announcement (FOA) Number PAR-16-370: Phenotypic and Functional Characterization of ApoE2 to Inform Translation Strategies for Aging-Related Conditions. This FOA encourages a focus on the Apolipoprotein E 2 allele in the belief that understanding mechanisms responsible for its apparent protective influence may improve our understanding of why some persons escape the vascular and neurodegenerative ravages of brain aging, while others suffer impairments and a shortening of their productive lives. Our application addresses a specific hypothesis: that the several health and aging phenotypes linked to the individual ApoE alleles are differentially modified or mediated by other genetic factors that travel with each ApoE allele by virtue of their contiguity on chromosome 19. Instead of limiting analyses to the ApoE alleles by themselves, we will examine and compare the conjoint influences of the ApoE2, ApoE3, and ApoE4 alleles, each with two other genes and several other genetic polymorphisms, linked by common membership in a limited number of haplotypes. The associations of those haplotypes and constituent genes with clinical, functional, and neuropathologic indicators of pathologic brain aging will be examined in deceased participants from three longitudinally studied cohorts – the Honolulu-Asia Aging Study, the 90+ Study, and the University of California San Diego Alzheimer's project.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$2,335 )
2022	2018	PACIFIC HEALTH RESEARCH AND EDUCATION INSTITUTE	3375 KOAPAKA ST STE I-540	HONOLULU	HI	96819	HONOLULU	USA	Aging Research	000	1	12/10/2021	SUPPLEMENT FOR EXPANSION	-$2,335
														Subtotal = -$2,335

Issue Date FY: 2018 ( Subtotal = $254,946 )
2018	2018	PACIFIC HEALTH RESEARCH AND EDUCATION INSTITUTE	3375 KOAPAKA ST STE I-540	HONOLULU	HI	96819	HONOLULU	USA	Aging Research	000	1	8/27/2018	SUPPLEMENT FOR EXPANSION	$254,946
														Subtotal = $254,946

Issue Date FY: 2017 ( Subtotal = $3,109,699 )
2017	2017	PACIFIC HEALTH RESEARCH AND EDUCATION INSTITUTE	3375 KOAPAKA ST STE I-540	HONOLULU	HI	96819	HONOLULU	USA	Aging Research	000	1	9/16/2017	NEW	$3,109,699
														Subtotal = $3,109,699

Grand Total All Awards = $3,362,310

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Apolipoprotein E2 and Brain Aging

Award Number: RF1AG056499

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2021

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