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The National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT)

Award Number: RC2DK140838
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/19/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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The National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT) - PROJECT SUMMARY Pituitary neuroendocrine tumors (PitNETs) are rare and understudied heterogeneous tumors that are detrimental to health causing increased mortality and poor quality of life. Cushing’s disease (CD) is a serious endocrine disease caused by an adrenocorticotropic hormone (ACTH)-secreting PitNET that subsequently stimulates the adrenal glands to overproduce cortisol. Chronic exposure to excess cortisol has several detrimental effects on health, including increased stroke rates, diabetes, obesity, depression, anxiety, and a threefold increase in the risk of death from cardiovascular disease and cancer. Despite decades of research, current treatments for CD remain suboptimal, and the development of targeted therapies is challenging due to the limited knowledge of PitNET tumor cellular and molecular complexity. The RC2 will fund the National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT) which will be an open source, clinically relevant deep tumor phenotyping platform and biorepository. This is the first phase of a contin- uum of translational- and hypothesis-driven research that will accelerate the development of effective therapies for PitNETs, preventing tumor recurrences and improving remission rates and quality of life for patients. The BioPitNeT team will: 1) establish a large-scale unique resource within an infrastructure that will generate sus- tainable novel research tools benefiting investigators with focused translational research of PitNETs, and 2) implement interdisciplinary approaches and expertise to generate a resource that will foster translational and hypothesis-driven research in PitNET diseases. The Registry for Adenomas of the PItuitary and related Disor- ders (RAPID) is a twelve center US consortium founded in 2021 to improve treatment of patients with PitNETs and funded by grateful patients. The BioPitNet leverages the RAPID Consortium clinical platform to combine clinical annotations of future prospectively enrolled patients with molecular and pathological information using state-of-the-art preclinical models. The low incidence of CD requires multicenter collaboration and interdiscipli- nary team science partnerships between basic- and clinician-translational scientists comprising the expertise of professionals trained in complimentary fields including medical and surgical treatment, neuropathology, molec- ular genetics of PitNETs, molecular pathology and high-plex spatial imaging, organoid and iPSC technology, canine comparative oncology disease models and translational bioinformatics. The BioPitNeT will be estab- lished by the successful completion of Aim 1: To establish the BioPitNeT centralized biorepository comprising of resources that will be benchmarked to the patients’ PitNET tissue of origin, Aim 2: To develop a PitNET clinically relevant classification system for CD, and Aim 3: To establish a biobank of induced pluripotent stem cell (iPSCs) lines genetically engineered to model corticotroph subtype PitNETs as a resource for investigating genetic underlying mechanisms of CD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,697,340 )
2026	2026	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	3	8/4/2026	NON-COMPETING CONTINUATION	$2,697,340
2026	2024	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	3/4/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2026	2024	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	2/25/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $2,697,340

Issue Date FY: 2025 ( Subtotal = -$6,293 )
2025	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	5/6/2025	NEW	-$2,825,642
2025	2024	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	2	7/31/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	1	7/7/2025	NEW	$0
2025	2024	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	5/7/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2,819,349
														Subtotal = -$6,293

Issue Date FY: 2024 ( Subtotal = $2,845,159 )
2024	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/30/2024	NEW	$2,845,159
														Subtotal = $2,845,159

Grand Total All Awards = $5,536,206

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The National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT)

Award Number: RC2DK140838

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/19/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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