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Developing the Context-Aware Multimodal Ecological Research and Assessment (CAMERA) Platform for Continuous Measurement and Prediction of Anxiety and Memory State

Award Number: R61MH135405
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Developing the Context-Aware Multimodal Ecological Research and Assessment (CAMERA) Platform for Continuous Measurement and Prediction of Anxiety and Memory State - Summary/Abstract (30 line max): This project seeks to develop the CAMERA (Context-Aware Multimodal Ecological Research and Assessment) platform, a state-of-the-art open multimodal hardware/software system for measuring human brain–behavior relationships. CAMERA will record neural, physiological, behavioral, and environmental signals, as well as measurements from ecological momentary assessments (EMAs), to develop a continuous high-resolution prediction of a person’s level of anxiety and cognitive performance. CAMERA will provide a significant advance over current methods for human behavioral measurement because it leverages the complementary features of multimodal data sources and combines them with interpretable machine learning to predict human behavior. A further distinctive aspect of CAMERA is that it incorporates context-aware, adaptive EMA, where the timing of assessments depend on the subject’s physiology and behavior to improve response rates and model learning. Our initial work on CAMERA focuses on predicting anxiety state and concurrent memory performance, but the platform is flexible for use in various domains. Our work on CAMERA consists of two phases. First, in the R61 phase, we will develop the CAMERA hardware/software framework, which includes methods for recording continuous neural, physiologic, audiovisual, and smartphone-usage data (Aim 1) and synchronizing these signals with intermittent EMAs (Aim 2). After demonstrating that CAMERA can successfully combine multimodal features to predict a subject’s anxiety state and memory efficiency (Aim 3), we will proceed to the R33 phase of the project. In the R33, we will use CAMERA in conjunction with closed-loop neurostimulation to modulate the subject’s anxiety state and associated memory performance (Aim 1), and to characterize the causal effect of modulation on neural, physiologic, and behavioral biomarkers (Aim 2). Beyond our initial work in the domain of anxiety and memory, we anticipate that CAMERA will have widespread impact by providing a general platform for exploratory and hypothesis-driven research on various aspects of complex human internal states, behavior, and cognition in real-world environments while minimizing burden on subjects.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $988,446 )
2026	2026	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	3	2/23/2026	NON-COMPETING CONTINUATION	$988,446
														Subtotal = $988,446

Issue Date FY: 2025 ( Subtotal = $890,772 )
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	2	9/16/2025	NON-COMPETING CONTINUATION	$0
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	2	7/25/2025	NON-COMPETING CONTINUATION	$890,772
														Subtotal = $890,772

Issue Date FY: 2024 ( Subtotal = $1,079,407 )
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	002	1	1/22/2024	NEW	$0
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	1	1/3/2024	NEW	$116,356
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	1	12/28/2023	NEW	$963,051
														Subtotal = $1,079,407

Grand Total All Awards = $2,958,625

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Developing the Context-Aware Multimodal Ecological Research and Assessment (CAMERA) Platform for Continuous Measurement and Prediction of Anxiety and Memory State

Award Number: R61MH135405

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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